The maple leaves in Yuelu Mountain are red all over the floor again.

Liuyang River continues its nine-bend waterway.

Inflow into Xiangjiang River and breed children of Huxiang.

The beautiful land and water continent is still full of vitality.

This is the environment in which we live.

But some people want to destroy it.

On June 5 this year, Changsha Intermediate People’s Court set up an environmental resources court to hear cases involving environmental resources protection according to law. Over the past year, under the guidance of the supreme leader’s ecological civilization thought, Changsha two-level courts have actively tried environmental resources to make the mountains greener, the water clearer, the sky bluer and the clouds whiter, and provided strong judicial guarantee for ecological security protection on the basis of the results of centralized trial and implementation of "Spring Thunder Action" in protecting "Mother River" and "Mother Lake". Fully safeguard the ecological environment safety and public environmental rights and interests in Liuyang River, Laodao River and Nanchuan River basins.

one

One kilogram of electric fish was sentenced to release 1600 fry.

The pictures in this article are all from the "Changsha Intermediate People’s Court" WeChat WeChat official account

Basic case: Since April 1, 2016, the Changsha Municipal People’s Government has banned fishing all the year round in the waters of Liuyang River from Xiangjiang River estuary to Dongtunduqiao. At about 21: 00 on June 13, 2018, Ye Moguo and Deng Mou were in the no-fishing area on the west side of Wanjiali Viaduct in Liuyang River, Furong District, Changsha City. Ye Jianguo used a battery electric shock fishing device for illegal fishing, and Deng Bo was responsible for using barreled fish. About an hour later, he was arrested by the police on the spot. Seizure of a set of electric shock fishing devices, a plastic bucket, two headlights and various illegally caught aquatic products.

Referee’s result: The court ruled that Ye Mouguo was guilty of illegal fishing of aquatic products, and sentenced him to 2 months’ criminal detention and suspended for 3 months. Ye Moguo and Deng Mou, the defendant in the incidental civil public interest litigation, shared the responsibility of repairing the fishery ecological environment and fishery resources, and put no less than 1,600 silver carp and bighead carp in their electric fish waters, weighing more than 80 kilograms, with 50% silver carp and bighead carp fry each, and publicly apologized in the news media at or above the municipal level.

2

In order to eat fish, father and son were both sentenced for fishing during the fishing ban.

Basic case: In order to have fun and improve food, Chen Mou Fu took his son Chen Mou Fang to the waters of Laodao River in Changsha for electric fishing. The two men drove to the waters of Laodao River with electric fishing tools brought from their hometown, and carried out illegal fishing during the fishing ban and fishing ban. Chen Mou Fushen’s back battery is responsible for electric fish, and Chen Mou Fang is carrying barreled fish to catch two kilograms of various aquatic products. The two were arrested by the public security organs after being reported by the masses.

Referee’s result: Defendant Chen Mou Fu committed the crime of illegal fishing of aquatic products and was sentenced to three months’ criminal detention and suspended for three months; Defendant Chen Mou Fang was convicted of illegal fishing of aquatic products and sentenced to two months’ criminal detention and suspended for two months.

three

A 60-year-old man who discharged nearly 300 times of zinc-containing wastewater was sentenced

Basic case: In August 2017, the defendant Sun Mouxian started to set up a galvanizing workshop in the rented demolition transition room, mainly engaged in punching processing of metal products and galvanizing in electroplating bath. On October 20, 2017, the Monitoring Brigade of Tianxin District Environmental Protection Bureau conducted an on-site inspection of the workshop, and found that Sun’s galvanized workshop did not go through any environmental assessment procedures and had no sewage treatment facilities. The raw materials used were mainly iron plates, zinc ingots and galvanized blue-white passivators, which were discharged. In this workshop, four vats of tap water are used to cool the galvanized sheet, and the wastewater is directly dumped in the courtyard, and flows into the drainage ditch and rainwater ditch together with domestic water and rainwater, and directly discharged to the vegetable field outside the wall without any treatment. After testing, the total zinc emission exceeds the national standard by 100-300 times.

Referee’s result: Defendant Sun Mouxian was sentenced to one year’s imprisonment and fined 10,000 yuan for environmental pollution.

four

The first case of environmental pollution caused by illegal disposal of hazardous waste was convicted.

Basic case: Defendants Cao Moumou, Zhang Moumou and Li Mou are the legal representative, deputy general manager of quality management and manager of quality management department of the pharmaceutical company of the defendant unit respectively. On the morning of February 7, 2018, due to the excessive accumulation of expired drugs and unqualified drugs in the unqualified warehouse, the pharmaceutical company needed to deal with them in time. After discussion and discussion, it was decided to transport the above-mentioned drugs to a construction site on the west side of Dongqi Road in Changsha County for direct incineration and burial. On the afternoon of the same day, Zhang Moumou and Li transported the drugs that needed to be treated by truck to the place designated by Cao for incineration, which was discovered by the staff of Changsha County Administrative Law Enforcement Bureau.

Referee’s result: The actions of the defendant’s pharmaceutical company, the defendants Cao Moumou, Zhang Moumou and Li Mou all constituted the crime of environmental pollution, and at the same time, it was found that the defendant’s pharmaceutical company was fined 60,000 yuan according to law, and the defendants Cao Moumou, Zhang Moumou and Li Mou were sentenced to fixed-term imprisonment ranging from one year to six months and fined.

five

The first case of criminal incidental civil environmental public interest litigation in the city

Basic case: At 19 o’clock on August 31, 2017, Xiong and Wang drove an electric fishing boat to fish with electricity in the waters from Caijiazhou to Hongjiazhou in Wangcheng District of Xiangjiang River. At about 22 o’clock that night, the police rushed to the scene to arrest Xiong and Wang. On the spot, the police seized an electric fishing boat used by Xiong and Wang, a Sanxiang AC synchronous generator, two electric fishing rods, two fishing nets, a plastic bucket for fish and 17.48 kilograms of aquatic products.

Referee’s result: Defendant Xiong violated the laws and regulations on the protection of aquatic resources, and together with Wang, he used the method of banning electric fish in the no-fishing area and during the no-fishing period. The circumstances were serious, and his behavior constituted the crime of illegal fishing of aquatic products. The defendant Xiong was convicted of illegal fishing of aquatic products and sentenced to one year’s imprisonment. The criminal judgment of Shanghai Pudong New Area People’s Court (2016) No.2825 at the beginning of sentence 0115 was revoked, and the defendant Xiong was suspended for three years for committing credit card fraud. The combination of two crimes decided to execute three years’ imprisonment; Confiscate criminal tools according to law; Defendant Xiong and defendant Wang shared the responsibility of destroying the fishery ecological environment and restoring fishery resources, and publicly apologized in the news media above the municipal level.

six

If you are lucky enough to traffic camphor, you will plead guilty and be punished for violating the criminal law.

Basic case: Since February 2018, Liu Moxiu has contacted Wen Mousheng and others, and agreed to purchase camphor trees with DBH of 15cm, 18cm and 20cm at the price of each plant in 120 yuan, 140 yuan and 160 yuan, and paid a deposit of 2,000 yuan to Wen Mousheng. In order to make illegal profits, it is also agreed to purchase "Cinnamomum camphora" by doping. At the beginning of March, Wen Mou-sheng dug 21 camphor trees in his own hilly land, and together with Wen Mou-bing, he bought 47 camphor trees at the price of each tree in 40 yuan, made them into "bald seedlings" without soil balls, and sold them to Liu Mou-xiu for 8,840 yuan. On March 12th, Liu Moxiu transported 68 camphor trees and 11 camphor trees purchased from other places to Shuangjiangkou Town, and was seized by Ningxiang Forest Public Security Bureau. Seven camphor trees were found to be the national second-class key protected plants, of which six were excavated by Wen Mousheng from his own mountain, and one was acquired by Wen Mousheng and Wen Mobing.

Referee’s result: Wen Mousheng, Wen Mobing and Liu Moxiu all violated the provisions of Article 344 of China’s Criminal Law, which respectively constituted the crime of illegally purchasing and selling state-protected plants and the crime of illegally purchasing and transporting state-protected plants. The court sentenced three people to criminal detention and fined them.

seven

Arbitrary discharge of sewage is punished

Basic case: The defendant Su Mou carried out illegal electroplating without obtaining environmental impact assessment documents, going through environmental protection-related examination and approval procedures and having no pollution prevention facilities. The generated wastewater is directly discharged into the sewer and seepage pit without any leakage-proof facilities. After testing, the discharged wastewater contains heavy metal toxic substances such as hexavalent chromium and zinc, which exceeds the national discharge standard of electroplating pollutants and causes serious pollution to the environment.

Referee’s result: After hearing the case, the court held that the defendant Su Mou violated the state regulations and discharged wastewater containing heavy metals and toxic substances, which seriously polluted the environment. He was sentenced to one year and six months’ imprisonment for environmental pollution and fined RMB 10,000.

eight

Illegal fishing of aquatic products was sentenced.

Basic case: On the evening of March 13th, 2018, Mao Mouyou and his son Mao Mobao illegally fished in conservation zone, a national aquatic germplasm with endemic fish in Liuyang River, from the sewage outlet of Daxi River in Mazhou Community of Dahu Town to Rubber Dam Hydropower Station. In four hours, Mao Mouyou and his son captured 10.85 kilograms of aquatic products such as grass carp and carp in the waters.

Referee’s result: After hearing the case, the court held that Mao Mouyou and Mao Moubao violated the laws and regulations on the protection of aquatic resources, and used prohibited methods to catch aquatic products in the no-fishing area and during the no-fishing period. The circumstances were serious, and their actions both violated the provisions of Article 340 of the Criminal Law of People’s Republic of China (PRC), which constituted the crime of illegal fishing of aquatic products. At first instance, Mao Mouyou was sentenced to six months’ imprisonment, and Mao Moubao was detained for four months and suspended for four months.

# Operation Spring Thunder #

Since 1950, the world population has nearly doubled. But since 1950, we have made more fundamental changes to our island, the earth, than in the past 200 thousand years. Mountains, rivers and energy are all decreasing rapidly. In order to give children a green mountain and clear water to grow up in, what we have to do is to unite as one and resolutely crack down on environmental pollution. This is not an individual behavior, but should be the goal of families, groups and even all mankind!

What matters is not what has disappeared, but what we have now. We still have half the world’s forests, thousands of rivers, lakes and glaciers, and thousands of biological species.

So, take action and protect your home by yourself!　

(The original title "Changsha court warned by case: those who destroy the ecological environment have to stop! 》）

Concept poster of Journey to the West: The Country of Daughters

1905 movie network news　The third part of the fantasy romantic comedy The Journey to the West series will be launched in November this year, and the schedule is scheduled in advance, and it is scheduled to play the Spring Festival file again and again at the beginning of 2018. A few days ago, the film released heavy news again, and Bo Huang, the powerful film winner, will also join "Girl Country" and transform for the first time, becoming one of the producers behind the scenes. It is understood that following the release of Monkey King Thrice Defeats the Skeleton Demon, two billion-dollar blockbuster movies, the The Journey to the West series has entered a mature stage, and it has become the leading Chinese film super IP. This time, "Girl Country" teamed up with Bo Huang, and the film has been absolutely eye-catching before it started, and its future market performance is also expected.

Bo Huang served as the producer of Journey to the West: The Country of Daughters behind the scenes of transformation.

Bo Huang is the first producer to lock the authentic Westward Journey series.

As a powerful film emperor with great box office appeal, Bo Huang, the producer of "Girl Country", attracted people’s attention. From 2006 to now, Bo Huang has appeared in many works that have won both word-of-mouth and box office, and has won numerous titles such as Golden Horse Award.

After ten years of success, the actor who focused on movies and roles turned his eyes behind the scenes. This time, as a co-producer of Girl Country, Bo Huang’s road to transformation seems to be traceable. During the Shanghai Film Festival in June this year, Bo Huang launched the "HB+U" new director assistance program, hoping to learn from the mature system of Hollywood film industry, select outstanding new directors for the whole society, and create excellent genre films. While pushing new people, Bo Huang also began to get involved in the development and production of film projects. Surprisingly, Bo Huang, who participated in the production of the film for the first time, did not choose the type of urban comedy he was good at, but turned his attention to the third film of the The Journey to the West series, Daughter Country. As we all know, the previous films, Make a scene in Heaven and Monkey King Thrice Defeats the Skeleton Demon, both closed at the box office of more than one billion yuan, and Bo Huang chose the third film of the same series as his first production, which was a unique insight.

Bo Huang is the producer of Journey to the West: The Country of Daughters, and the film will be launched in November.

"Girl Country" started in November, and the news climax continued.

The filmmaker recently announced that "Girl Country" will be officially launched in November this year, and the director is still Zheng Baorui. The director revealed that "Girl Country" will be based on the new production team. At present, most of the 2,400 crew members of "San Da" have started to return to the team and enter the preparations for the new film. The special effects team with an elite of more than 1,000 people from multinational industries is bound to further improve the production level of "Girl Country", of which only one special effect will cost tens of millions of dollars, which will set a new benchmark for Chinese special effects films after "Monkey King Thrice Defeats the Skeleton Demon".

At the same time, in terms of plot, the story of "Girl Country" will be richer in maintaining the essence of the original, and the plot will be more suspenseful and fresh. For the core plot that everyone is familiar with, there will be a new interpretation of the affection between Tang Priest and the king of the daughter country. At the first press conference on August 15th, William Feng and Xiao Shenyang announced that they would continue to star in "The Country of Daughters", and other starring roles would be announced one by one before the launch.

Poster of global auditions for thousands of people in the daughter country

At present, the live draft of "Next Stop, Girl Country" is in full swing, and sea elections will be held in Beijing, Shanghai, Guangzhou and Chengdu, and 1,000 "girl country nationals" will be selected for the movie "Girl Country" to create "the world’s most actress movies".

　　More than 300,000 yuan for Porsche and 600,000 yuan for Bentley Rolls Royce? Smart, when you see such an advertisement, you must know that there are a lot of tricks. However, all-media reporters have noticed on major websites and community platforms that similar advertisements for selling luxury cars at ultra-low prices are endless every year, especially near the end of the year. Recently, the traffic police department announced some cases of car inspection, pointing to the risks and hazards of buying low-priced luxury cars. However, there are still many people who are willing to "pretend to be confused" and covet small bargains. Che Tianxiajun digs the stories behind these low-priced luxury cars for everyone.

　　Text/Photo: Guangzhou Daily All-Media Reporter Deng Li

　　[Price Check] There is a market for smuggling cars at a low price.

　　Rolls-Royce, Bentley, Ferrari, Lamborghini … … These familiar luxury cars are super-running, which is the dream of many people. Where there is demand, there is a market. A shady smuggling channel has been quietly selling ultra-low-priced luxury cars in the market for many years. This is what we often call water trucks. How cheap is the smuggling car? Take a 2015 Porsche Cayenne GTS as an example. The guide price of a new car is more than 1.5 million yuan, and the price of a used car with a car age of about 1-2 years ranges from 1 million to 1.3 million yuan, but it only takes more than 300,000 yuan to smuggle. A 2012 Bentley speeding at a price of 5 million yuan, the normal second-hand price is 1.3 million to 2 million yuan, but the smuggling car only needs 600,000 to 700,000 yuan. In other words, you can buy a top luxury car at the price of a small BMW or a big Mercedes-Benz. No wonder some people are excited.

　　The reporter noticed that the current "publicity" channels of car smugglers mainly rely on automobile communities and forums, followed by the spread of WeChat friends circle. In a rider forum, a reporter casually saw an advertisement: "Hummer, Porsche, 400,000 yuan, Touareg, 300,000 yuan, Bentley, 600,000 yuan can win … …” Followed by more than a dozen riders’ consultation posts. As for why it is so cheap, the poster explained that the original imported new cars sold by domestic 4S stores are all declared in the form of bulk import trade, and the state has imposed a high import tax. Their original imported cars are declared in the form of small import trade or goods, so the price is attractive. It sounds like that, but is it?

　　[Source Exploration] Most of them are illegal inflows of used cars in the United States.

　　The vehicle management department pointed out that at present, there are only two legal channels for regular imported cars. One is the medium-sized imported cars imported by automobile OEMs and sold by authorized dealers, and the other is the parallel imported cars imported through regular ports in countries such as Tianjin Port and Nansha Port. Those imported luxury cars that are far below the market price are not the same as the "parallel imported cars" that have already obtained the import status through formal channels.

　　How did these cars get into the domestic market? All-media reporters contacted a car smuggler by selling the phone number of car smuggling online. The other party claimed that he was in Dongguan. If the price was satisfactory, he could drive the car to Guangzhou and pay for it. After several communications, the smuggler also revealed a lot of information. He said that Huangjiang, Dongguan, where he is located, is the most concentrated place for smuggling cars, and most of them come from the used car market in Europe, America and Europe.

　　All-media reporters learned that the warranty period of new cars in the United States is generally three years, and the warranty cost will increase greatly after the warranty period, so many Americans will sell them after the warranty period. Therefore, the used car market in the United States is very large and cheap. These cheap used cars have become the main source of smuggled cars in China. Car dealers first import cars to Hong Kong duty-free and then smuggle them to the mainland through Hong Kong. The vehicle management department pointed out that these smuggled cars do not have legal "identity cards" and cannot be licensed in the vehicle management office.

　　[Turning into the road] All rely on the "deck" traffic police to directly detain the car.

　　There are policies and countermeasures, and car dealers try their best to sell smuggled cars. The traffic police department pointed out that the most common way for car smugglers to help buyers "get on the card" is "deck", and it has formed a "professional" operation. Through their own channels, these illegal car dealers first find the regular vehicles with the same model and color as the smuggling vehicles, and then according to the real information of the regular vehicles, transform the identification code, frame number and engine number of the smuggling vehicles into the same as the legal vehicles, and forge a set of identical documents at the same time. This is the most common method of licensing the smuggling vehicles.

　　"Others directly set the license plates of the same model bought by their relatives and friends. They are separated by two places, and each driving their own car does not interfere with each other, and it is even more difficult to be found." The traffic police pointed out that the deck car is definitely not transferable. Of course, there is also a wonderful way to set up a deck, let the owner report the loss of a set of driving license, and then change the frame number and engine number of the smuggled car to the same as the legal car under his name. In this way, it can be used in different parts of the country with less money. Some car smugglers will find various underground channels to handle legal temporary license plates, which is also a relatively more "safe" deck method. Although there are many ways for smugglers to deck cars, the traffic police pointed out that the risk of deck cars is very high, and once they are found, they will directly detain them. "No matter how realistic the fake license and number plate are, they can be easily identified." According to China’s traffic laws and regulations, vehicles that use forged license plates will be detained without relevant formal and legal procedures, and those involved will be fined less than 5,000 yuan.

　　[Tip] Don’t get carried away by the cheap.

　　The price of smuggling cars is very low, but don’t be carried away by the cheapness. Mr. Liu, a local second-hand car practitioner, told the reporter that smuggling cars is not only illegal on the road, but also risky from its source. It is reported that at present, the sources of smuggling cars are not only domestic used cars eliminated in European and American markets, but also foreign stolen vehicles, scrapped or smuggled parts assembled vehicles. Many of these smuggled cars are accident cars and scrapped cars. After dismantling the flying roof and reassembling the paint, the appearance looks bright and beautiful, but the vehicles can’t meet the safety standards originally designed. In addition, due to the different sales areas, the condition of smuggled cars may not be suitable for domestic use. For example, some smuggled cars are equipped with a temperature protection device for their engines in cold areas. Once such vehicles are used in the south of China, the engines will frequently stall and cannot be used normally. Moreover, domestic oil products and road conditions are also easy to make smugglers "acclimatized" and cause endless troubles to car owners in maintenance.

　　[Case link] More than 3 million Bentley 620,000 bought?

　　Recently, a post-90s boy in Hunan bought a Bentley car worth more than 3 million yuan "smoothly" for only 620,000 yuan, and happily drove home in a luxury car. However, on the afternoon of December 14th, the young man and his Bentley were stopped by the traffic police at Xiaotang Toll Station of Beijing-Hong Kong-Macao Expressway. When the traffic police checked Bentley’s driving license and license plate, they found that all of them were forged and the license plate was also a deck. The young man told the traffic police that this Bentley was purchased after he saw the barrage advertisement on a website. Although he once suspected that the vehicle was not quite right, he found a so-called friend to help him check and said that there was nothing wrong with the car. Now this Bentley has been seized by the local traffic police and is suspected to be a parallel deck car. The young man’s car purchase of 620,000 yuan is a waste of water. Although it is really undesirable to be so greedy and cheap, there are quite a few similar cases, and there are different ways to buy them. "The Porsche I bought is basically used in my hometown and countryside. As long as it is not illegal, it has never been checked. If I need to drive a long distance or drive in a big city, I will still drive the car bought through formal channels. " Mr. Kong Kong of Guangxi, who is doing business in Guangzhou, told reporters that he bought two smuggling cars. A year ago, I spent 350,000 yuan to buy a smuggled Land Rover. After my fresh addiction, I recently contacted the same used car company. After selling Land Rover for 400,000 yuan, I spent 300,000 yuan to buy a Porsche Cayenne, which was enough for luxury car addiction.

　　Yantai Development Zone Senior Middle School held the ceremony of campus youth adulthood. Photo courtesy of Yantai Education Bureau

　　editorial comment/note

　　In the process of educational reform and development, many typical models have emerged. They have had an important influence and made important contributions in the history of new China’s education development. For many years, they have also been persistent in the journey of educational reform. In order to present these typical new achievements and experiences in further promoting education reform, starting from today, this newspaper will open the column of "70 Years of Magnificence and Typical Return Visit in the New Era of Struggle", and successively publish the typical return visit reports that have been launched by this newspaper, so please pay attention.

　　Quality education is an unavoidable topic in contemporary China education. From the early days of reform and opening up, many places have begun to explore hard. In this exploration, Yantai is another unavoidable place.

　　In 1984, the first experimental area of educational reform in China was born in Yantai. In 1990, the State Education Commission identified Yantai as a pilot city for comprehensive urban education reform in China. In 1992, Yantai’s experience in quality education reform attracted much attention, and People’s Daily and China Education News reported it one after another. In September 1997, the national experience exchange meeting of quality education in primary and secondary schools was held in Yantai, which became an advanced model of quality education in China.

　　In the development history of quality education, the pace of Yantai people’s reform has never stopped. For more than 30 years, they have unswervingly implemented quality education and written a rich and colorful stroke.

　　Recently, our reporter went deep into Yantai, Shandong Province for investigation and interview, revisited the forefront and fiery scene of the reform in that year, and analyzed the latest progress of quality education reform, with a view to providing a reference model for the latecomers who promote quality education today with Yantai, the "living fossil" of quality education.

　　From the individual to the whole — —

　　Always take the growth of students as the foundation.

　　Qu Wenteng, a chemistry teacher at Dayao Middle School in Muping District, is very happy in recent years. Because of the appearance of the tutorial case, a teaching pain point that has plagued him for many years has been solved at once: the problem of uneven students’ level — — Some people don’t have enough to eat, and some people can’t eat.

　　The guiding plan adheres to the design principle of few, precise and thoughtful. By designing hierarchical learning objectives, leading questions and corresponding exercises, students with different learning situations can be guided to find their own content and methods. This efficient classroom reform with the guidance plan as the core has been carried out in Dayao Middle School for more than ten years. President Sui Zhengong said that this model is based on respecting students’ differences, aiming at developing students’ differences and cultivating students’ self-learning ability, and its core is student-oriented.

　　Speaking of the concept of differentiated teaching, Sui Zhengong said that this is actually in line with the junior high school quality education reform implemented by Dayao Middle School more than 30 years ago.

　　Back in the 1980s, in order to consolidate the achievements of "Nine-Year General Education" and better implement quality education in junior high schools, Yantai City, starting from the goal of all-round development, lost no time in launching the overall reform plan of "two-for-all, two-for-four reform" with classified guidance and separate teaching as the main ways, with 16 different types of junior high schools such as Dayao Middle School in Muping District, Beima Middle School in Longkou City and Qixia Experimental Middle School taking the lead in "classified guidance".

　　Dayao Middle School at that time was the pioneer of reform. Under the leadership of Li Peizhi, then principal of the school, the school explored and built a junior high school education model of "two parts", which was praised as "the golden key to open junior high school quality education". Subsequently, Dayao Middle School was recognized as "an advanced model of quality education in primary and secondary schools in China" by the State Education Commission and relevant experts. In September 1997, the State Education Commission held a national experience exchange meeting on quality education in primary and secondary schools in Yantai, and Dayao Middle School was selected as a "junior high school" to visit the site.

　　From the individual to the whole, this question, which was once placed in front of Li Peizhi and Sui Zhengong, got a similar answer in line with the spirit of the times under the concept of differentiated teaching.

　　More than 30 years have passed, and the research on differential education has never stopped in Yantai. The research on differential education has become an excellent research project that regional professional researchers and front-line principals and teachers have participated in and adhered to for 23 years. More than 1,000 experimental teachers from 212 experimental schools have participated in the project experiment. The research achievement won the second prize of provincial basic education teaching achievement twice in a row.

　　Focusing on the all-round development of students, the student-oriented curriculum reform is being continuously and comprehensively promoted in Yantai. At present, differentiated teaching has been extended to all disciplines and all aspects of school work, and different students have obtained development paths suitable for their own growth here.

　　From result to process — —

　　Always take evaluation reform as the guide.

　　Sports and art are a happy thing in Laizhou bilingual school. This is the goal that President Zhao Fuqing has been pursuing for many years. "I just want to make sports and art change from passive to conscious, from task to interest, and from result to process."

　　In order to achieve this goal, the school has set up a set of evaluation system of physical arts based on process evaluation, such as classroom observers, nine-day sports meeting, home sports homework, sports cooperation teaching, and the evaluation scheme of "physical fitness+skills" & HELIP; …

　　The sports meeting of Laizhou Bilingual School lasts for 9 days, from class to department and then to the whole school. Everyone is an athlete and everyone can get evaluation. During holidays, with the participation of parents, students have to complete a physical exercise every day; In the classroom, evaluation is divided into teacher evaluation and student evaluation, and student evaluation evaluates and summarizes the performance of each group by classroom observers in each class … …

　　Zhao Fuqing, who has been teaching for many years, has participated in and experienced the quality education reform in Yantai for many years. In his view, Yantai’s sports and arts reform comes down in one continuous line.

　　After the resumption of the college entrance examination in 1977, Yantai’s enrollment rate has been among the best in Shandong Province, and people used to be proud of it. Later, in order to pursue the enrollment rate, some schools began to take further studies as the baton and cut off the courses of music, physical education and beauty.

　　The reform of quality education in Yantai begins with the reform of examination system and evaluation system. First of all, the reform of the 100-point system was abolished in primary schools, and the evaluation method of "grade+specialty+comment" was implemented to liberate primary school students from the weight of scores. All subjects in primary schools are assessed by sub-items, and rated according to four grades: excellent, good, passing and failing. The assessment will be carried out by combining the daily examination with the comprehensive examination.

　　Looking back on the past, how similar this is. Since 2012, Yantai Education Bureau has studied and put forward the idea of school physical education reform of "scientific research leading, administrative promotion, point-to-area and regional promotion", taking the lead in establishing the development concept of "healthy sports, scientific sports and all-round sports" in the country. After more than six years of exploration and practice, the city’s education system has gradually established a five-in-one school physical education reform system of "complete guarantee, curriculum optimization, training promotion, competition guidance and standard guidance", laying a solid foundation for students’ lifelong physical education.

　　From the baton focusing on results to the evaluation system focusing on process, Yantai quality education has blossomed in various campuses. On the campus of Penglai No.2 Experimental Primary School, the hall of the teaching building has become a stage for students to display, and the most conspicuous wall is reserved for the "one-star" students who perform best every month. Even the piano in the corner has become a stage for students to compete for display, and the campus is full of students’ cheers and smiling faces. At the Second Experimental Primary School in Muping District, every day at noon, the reading forum starts on time and persists every day, rain or shine. This normalized speech activity has cultivated students’ confidence and ability to speak and express in front of everyone.

　　From school to society — —

　　Always aim at all-round development.

　　For students living in Yantai, social practice is a necessary action to participate in and complete with their parents.

　　Since the summer of 2013, Yantai has organized and guided students and parents to participate in the social practice activities of "practice base group, social big classroom" in the city by means of "parents’ full participation and timely guidance from the school", and entered social venues such as museums, nuclear power plants and air forces that are open to primary and secondary school students free of charge.

　　After more than six years, Yantai has gradually established a comprehensive practical activity curriculum system with the theme of "ideal moral construction, vocational skills training, scientific exploration and innovation, and comprehensive quality improvement" and the characteristics of "school+base group". Up to now, Yantai has built 33 municipal social practice listing bases, 139 county-level listing bases and 560 school-level listing bases, and the characteristic practice education base group of primary and secondary schools has begun to take shape.

　　The comprehensive practical curriculum system in full swing is just one of the two wings of the new regional integrated moral education curriculum system that Yantai has continuously promoted in recent years. On the whole, Yantai’s framework is a new framework of "one subject and two wings" regional integrated moral education curriculum, which focuses on subject moral education curriculum and takes traditional culture curriculum and practical activity curriculum as two wings.

　　"The outstanding feature of the new system of Yantai regional integration moral education curriculum is three combinations." Xu Jianmin, director of Yantai Education Bureau, introduced that the combination of administrative decision-making and scientific research guidance, inheritance and innovation and development, and school, family and social education should be adhered to.

　　Since it was established as a national experimental area for educational reform in 1984, Yantai has made rich experience and achievements in the field of moral education reform in primary and secondary schools while deepening the reform of quality education. On the one hand, Yantai organically integrates the scattered experience of a single point, and then grasps the point and gives full play to the role of demonstration radiation; On the other hand, based on the new situation and requirements of moral education and the new situation and problems of school moral education reform and development, the classic educational wisdom is organically integrated into the brand-new moral education practice.

　　After three years of exploration and practice, the reform and development of integrated moral education curriculum in Yantai city is in good condition. Five schools in the city have been rated as national excellent Chinese traditional culture demonstration schools, and the moral education courses of more than 130 schools have become gold medals in their respective districts and cities, becoming the "favorite" for school principals and teachers in the city and the region to watch and learn.

　　Walking into the second experimental primary school in Muping District, I was just catching up with an "apricot" thing at school: picking apricots. In the school’s "pocket garden" and dozens of apricot trees near the courtyard wall, golden and full apricots are ripe. The students excitedly and carefully picked the apricots they planted one by one.

　　President Jiang Yuemei introduced that in order to provide students with sufficient practice space and create opportunities for "working all the time", the school has carried out four aspects of work: developing "pocket vegetable garden" and building a labor platform; Scientific planting management to improve labor quality; Carry out research study to enhance labor skills; Take advantage of the charity sale and feel the meaning of labor. It is worth mentioning that according to the solar terms, the school compiled the school-based textbook "Follow the solar terms", and these "small farmers" followed the solar terms textbook to carry out inquiry learning and research.

　　In 2017, the integrated observation and exchange activities of moral education courses in primary and secondary schools in Shandong Province were held in Yantai, which was highly praised by the Provincial Department of Education and peers in the province. In 2018, the results of the integrated reform of Yantai moral education curriculum won the second prize of the provincial basic education teaching achievements.

　　From Method to Theory — —

　　Always guided by education and scientific research.

　　Under the observation and discussion of more than 600 people in two days, Yin Shaoping, the principal of Zhaoyuan Experimental Primary School, has a deeper and broader understanding of the "12xue internet plus Teaching Characteristic Model" that she insists on, and at the same time, she has strengthened her confidence in going on. In November 2018, the "Yantai Education and Scientific Research Tour" series of activities was held in Zhaoyuan, Yantai. More than 600 people from all the staff, principals of primary and secondary schools and key teachers of all counties and cities participated in the activities.

　　"This session is ‘ A trip to education and scientific research ’ The ninth stop. " Guan Xiji, Dean of Yantai Academy of Educational Sciences, said that this activity was started in 2010 in Yantai, and it entered a county every year. The number of participants exceeded 1,000 for many years. The content of the activity deepened year by year, and the coverage continued to expand. A large number of advanced units and outstanding teachers emerged with this platform, forming a core brand in the field of regional education and scientific research.

　　"Yantai’s quality education reform has always had an important principle — — Guided by scientific research. " Guan Xiji hit home.

　　Xu Jianmin put forward the basic requirements of "improving our work with research spirit, research thinking, research methods and research standards, taking research as a way of work and becoming the level of work we pursue", and "promoting educational research with administrative power and carrying out educational administration with research spirit".

　　It is under the guidance of research spirit that Yantai can break through the primary stage of finding solutions to practical problems and transform and refine various reforms into scientific tools and even theories in time. According to statistics, in 2016, the first outstanding achievements in educational science research in Shandong Province were selected, and Yantai ranked first in the province in terms of the number of awards, the passing rate and the fields involved; In 2017, the number, passing rate and categories involved in the annual project of the 13 th Five-Year Plan for Education Science in Shandong Province ranked first in the province; In 2018, the province’s basic education teaching achievement award passed the second place in the province; In 2019, the passing rate of basic education and teaching reform projects in Shandong Province once again ranked first in the province.

　　Thirty years of hard work. In the late 1980s, for a long time after the resumption of the college entrance examination, students, parents, schools and society were all pursuing the enrollment rate, and there were many calls for reform, and all localities explored ways to promote students’ all-round development. The quality education reform in Yantai is just the right time.

　　From "cancel the percentage system and implement ‘ Grade+specialty+comment ’ The evaluation method, liberating primary school students from the weight of scores ",to" implementing ‘ Classification guidance ’ , implemented in the graduation grade ‘ Diversion education ’ , don’t have to hordes to squeeze ‘ A wooden bridge ’ " Finally, to "reform the enrollment system of senior high school entrance examination, link the enrollment quota of senior high schools and technical secondary schools with the conditions and level of running schools in towns and villages, and turn the competition for further education into the competition for running schools" … …

　　In 1997, the national experience exchange meeting on quality education in primary and secondary schools was held in Yantai. The meeting not only summed up the experience, but also made a comprehensive plan and deployment for the implementation of quality education throughout the country. This marks that the reform of quality education in China has entered the stage of national reform from regional experiment.

　　Yantai contributed a lot.

　　Now, when you walk into Yantai, you will find that learning has become a happy and fulfilling thing. Students with comprehensive qualities have made great achievements in the college entrance examination and talented people have emerged in large numbers. Walking into Yantai, you will find that the implementation of quality education is no longer a slogan, but a real action by governments, schools and teachers at all levels; Walking into Yantai, you will find that the strategic vision and great courage of the pioneers of reform have been inherited in the same strain, and the motivation for reform has not diminished.

　　Yantai, always on the road … …

　　Our reporter Yan Yuekun Zhang Shenghua correspondent Lu Peng

　　Few things touch people’s hearts as much as health. Health care is the key to people’s livelihood.

　　More new drugs are on the market, "noble drugs" are included in the medical insurance drug list, the "healthy China" action plan is deepened, and the chaos of medical beauty is rectified with heavy blows … … In 2019, these medical and health events related to people’s livelihood attracted special attention. At the end of the year, people hope to further "improve quality" and "reduce prices", and expect relevant departments to prescribe more health "prescriptions" to continuously improve people’s sense of acquisition and happiness.

　　one

　　Responding to the challenge of drug resistance, Tu Youyou team clarified the mechanism of artemisinin drugs

　　Artemisinin is a gift from traditional Chinese medicine to the world, which has contributed to the global malaria control. However, in recent years, the underlying mechanism of artemisinin in the treatment of malaria is still unclear, especially the problem of drug resistance, which is also the biggest challenge facing the global malaria control.

　　The half-life of artemisinin in human body (the time required for drug concentration to drop by half) is very short, only 1-2 hours. The course of clinical recommended artemisinin combination therapy is 3 days, and the truly efficient insecticidal window of artemisinin is only limited to 4-8 hours. However, the existing drug-resistant insect strains make full use of the short half-life of artemisinin, change their life cycle or temporarily enter a dormant state to avoid the sensitive insecticidal period. At the same time, plasmodium can also produce obvious resistance to the auxiliary drug "antimalarial formula" in artemisinin combination therapy, which makes artemisinin combination therapy "ineffective".

　　On April 24th, Tu Youyou’s team published an article online in the top international medical journal "New England Journal of Medicine", saying that the recently clarified mechanism of artemisinin drugs shows that they are precursors activated by iron or heme. Iron and heme are by-products of hemoglobin digestion, reaching the highest concentration at the mature stage of plasmodium trophozoite. Once artemisinin drugs are activated, many protein and heme of parasites will be alkylated. Alkylation of heme can also inhibit the detoxification of heme. "It is speculated that the mutation of a single protein target is unlikely to cause drug resistance, which may also explain why artemisinin drugs are still effective after decades of widespread use." Wang Jigang, a member of Tu Youyou’s team and a researcher at Artemisinin Research Center of Chinese Academy of Traditional Chinese Medicine, said.

　　In this regard, the team proposed a new treatment response plan: First, appropriately extend the medication time; The second is to replace the adjuvant drugs that have developed resistance in artemisinin combination therapy.

　　2

　　Can the "white list" of medical beauty be cured?

　　Non-medical beauty places are engaged in medical beauty treatment, the practice of doctors with informal training, and the use of unqualified medical beauty products … … In recent years, the "three non-"chaos exposed by the media has repeatedly been criticized by the society.

　　On June 18th, the National Health and Wellness Committee indicated that China Plastic Surgery Association was studying and formulating a credit evaluation management system, and it was planned to conduct credit evaluation of beauty medical institutions in some areas on a pilot basis. "The data of hardware conditions and facilities, annual inspection and doctor qualification of medical beauty institutions will be connected with the existing credit system, and a medical beauty institution &lsquo will be established in the future; White list ’ , objectively present to the people ‘ White list ’ The situation of the organization. " Cao Dequan, deputy secretary-general of China Plastic Surgery Association and director of the evaluation office, said that at that time, the public can search for information on the special website.

　　Hu Jieren, an associate professor at Tongji University Law School, said that the system itself is highly scientific and operable. It can learn from the existing credit evaluation model, listen to social voices, list the characteristics of dishonesty, and ensure fair and strict punishment. At the same time, in addition to credit evaluation and other mechanisms, the governance of medical beauty chaos requires multi-dimensional efforts and the participation of the whole society. For example, the regulatory authorities should take the initiative and increase penalties.

　　three

　　The Healthy China Action Plan is issued. Everyone is the first person responsible for his own health.

　　In July, the "Healthy China Action Promotion Committee" established in the State Council released "Healthy China Action (2019— 2030), giving authoritative guidance on what to do, how to do it and who will take the lead in healthy China.

　　"Everyone is the first responsible person for his own health." Wang Xiaoning, director of the Institute of Geriatrics of the General Hospital of the People’s Liberation Army and secretary-general of the China Association for Science and Technology’s life science association, particularly agreed with this point in the document. He explained that WHO has already concluded that in the promotion and maintenance of national health, the contribution of medical care is less than 10%, which mainly depends on people’s lifestyle and living environment. Wang Xiaoning said: "It turned out that ‘ Grip ’ The focus is on the 10% part, and now it is necessary to put ‘ Grip ’ Put it in 90%, that is, people’s lifestyle and living environment. "

　　Experts say that it is not enough for doctors and health departments to embrace health. Cardiovascular and cerebrovascular diseases are the first cause of death among Chinese residents, "Healthy China Action (2019— In 2030), it is mentioned that the goal of healthy China will reduce the premature mortality rate of major chronic diseases from 18.5% in 2015 to no more than 15.9% in 2022. Yang Jingang, an associate professor at Fuwai Hospital of China Academy of Medical Sciences, believes that the goal can only be achieved by mobilizing social forces, and the organizational model of "Patriotic Health Campaign" can be used for reference. Only by linking disease prevention and control indicators with the performance and responsibility of district leaders can we coordinate all resources and really play a role.

　　four

　　Major projects support the initial establishment of a drug innovation technology system in China.

　　In view of the difficulties and expensive medical treatment for ordinary people, and the heavy dependence on imports of high-end medical equipment and drugs, as early as 2008, China deployed and implemented the major scientific and technological project of "major new drug creation" (hereinafter referred to as the new drug creation project).

　　"With the special support of new drug creation, a total of 14 Class 1 new drugs were approved after February 2017, showing a blowout growth." At the end of July, at the conference of "Creation of Major New Drugs", Chen Kaixian, deputy chief engineer of special technology and academician of Chinese Academy of Sciences, introduced that in the past two years, new progress has been made in the research and development of special varieties, and six Class I new drugs have been approved for the treatment of malignant tumors. In addition, the achievements of the special project of new drug creation include the first domestic and the second long-acting anti-AIDS drug, the new anti-infective drug, Clindamycin, which is independently developed, and the world’s first aromatic hydrocarbon receptor modulator and non-hormonal small molecule chemical drug, Benvimod & HELIP, which has therapeutic effect on psoriasis. …

　　The national drug innovation technology system has been initially established in the special project of new drug creation, and a series of technical platforms have been laid out; Initially, a grid-based innovation system with scientific research institutes and universities as the main source innovation, enterprises as the main technology innovation, the close integration of the upper, middle and lower reaches and the deep integration of politics and Industry-University-Research has been established, and the ability of independent innovation has been significantly improved.

　　five

　　The paper has sparked a heated discussion on whether "Aristolochic acid-induced liver cancer" is a real hammer or a misunderstanding.

　　In August, aristolochic acid once again became the focus. Han Zeguang, a professor at systems biomedicine Research Institute of Shanghai Jiaotong University, published a paper in the international journal Hepatology in the field of liver diseases, which was emphasized by many media as "aristolochic acid has caused liver cancer to have a real hammer". This study revealed that aristolochic acid alone can cause liver cancer in mice in a dose-dependent manner, that is, the greater the dose of aristolochic acid, the shorter the time to cause liver cancer and the larger the tumor. When aristolochic acid is combined with carbon tetrachloride, it can induce liver cancer in mice in a dose-dependent manner, including hepatocellular carcinoma and hepatocellular carcinoma and intrahepatic cholangiocarcinoma.

　　However, Luan Yang, a researcher at Shanghai Jiaotong University School of Medicine, and others believe that the data obtained by Han Zeguang’s team under certain experimental conditions are not enough to draw the conclusion that aristolochic acid causes liver cancer, and it cannot be called a "real hammer". "Specific experimental conditions" means that the experimental object is young mice and carbon tetrachloride liver injury model.

　　Some experts also said that some media interpreted the latest experiment of Han Zeguang’s team as "solid hammer" evidence that aristolochic acid is the main cause of liver cancer in China, but it should be noted that the original literature is in young mice (equivalent to 1-mdash; 2-year-old baby) and carbon tetrachloride liver injury model, which is different from the clinical occurrence of liver cancer, and many independent studies have been published in the world for many years, but no results of liver cancer caused by aristolochic acid have been made in adult mice, so it is too early to think that aristolochic acid is the main cause of liver cancer in China.

　　six

　　The original research drug went to sea for the first time, and the national research anticancer drug was approved for listing in the United States.

　　A movie, Dying to Survive, made anticancer drugs attract public attention. Subsequently, zero tariffs on imported anticancer drugs and negotiations on anticancer drugs have also become hot spots of public concern.

　　On September 23rd, the National Health and Wellness Commission and other 10 departments jointly issued the Healthy China Action — — Cancer prevention and treatment implementation plan (2019— In 2022) (hereinafter referred to as the "Program"), the "Program" pointed out that a set of "combination boxing" will be made by unblocking the temporary import channels of anticancer drugs that are urgently needed in clinic, promoting the substitution of generic drugs, and incorporating them into medical insurance, so as to improve the accessibility of anticancer drugs and enable ordinary people to buy, afford and use anticancer drugs in China.

　　The "Proposal" clearly stipulates that the zero tariff on imported drugs should be promoted, and various links such as R&D, production, procurement, import and use should be fundamentally straightened out, and the price of anticancer drugs will continue to decline, further promoting the simultaneous listing of new overseas drugs in China and avoiding the "foreign moon and domestic circle" caused by the difficulty in obtaining anticancer drugs.

　　Nowadays, the situation of "only getting in but not getting out" of original anticancer drugs has been broken. On November 14th, zanubrutinib, a BTK inhibitor developed by Baekje Shenzhou Company, was approved by the US Food and Drug Administration (FDA) for the treatment of adult patients with mantle cell lymphoma who had received at least one therapy before. At this point, "the drug became the first new anti-cancer drug independently developed by local enterprises in China and approved for listing by the FDA, realizing the new drug originally developed by China ‘ Zero breakthrough ’ 。” Dr Wu Xiaobin, general manager and president of Baekje Shenzhou China, said.

　　seven

　　Supervision is imminent. E-cigarettes are as harmful as traditional cigarettes.

　　Some businesses advocate that e-cigarettes are less harmful to human body and can help smokers quit smoking. Self-adjusting taste, cleanliness and environmental protection, and convenient use have all become eye-catching labels of e-cigarettes.

　　"Generally speaking, e-cigarettes will highlight the characteristics of high technology content and trendy fashion in product performance and ingredients. However, the ingredients of e-cigarettes are nothing more than nicotine, water, spices, propylene glycol and glycerol. As for the principle, it is even simpler, just an electronic evaporation, and there is no technology content at all." Zhang Zhigang, a senior engineer of China Environmental Behavior Law Society, said.

　　More seriously, consumers don’t know that under normal use conditions, the concentrations of some metals (including lead, chromium and nickel) and formaldehyde in some e-cigarette aerosols are equal to or higher than those in traditional cigarettes, and these harmful substances are even higher than the content of second-hand smoke produced by traditional cigarettes. In addition, e-cigarettes will also produce some toxic substances that are not found in traditional cigarette smoke, such as glyoxal, which is flammable, toxic and irritating, and its vapor or fog will stimulate eyes, mucous membranes and upper respiratory tract.

　　With the United States, Japan, India and other countries banning e-cigarettes to varying degrees, the voice that China should legislate and supervise e-cigarettes as soon as possible is getting louder and louder. Hu Qingyuan, director of the National Tobacco Quality Supervision and Inspection Center, said: "Fortunately, we have already started to act." On November 1, the State Tobacco Monopoly Bureau and the State Administration of Market Supervision jointly issued the Notice on Further Protecting Minors from E-cigarettes, urging enterprises or individuals that produce and sell e-cigarettes to withdraw their e-cigarette advertisements published through the Internet, and the supervision of e-cigarettes is becoming increasingly strict.

　　eight

　　Can cerebral palsy be cured? "Needle-sealing therapy" triggered a normative discussion on new therapy.

　　Cerebral palsy is recognized by the medical community as incurable. However, the media reported that the Third Affiliated Hospital of Zhengzhou University (hereinafter referred to as the Third Affiliated Hospital of Zhengzhou University) adopted "needle sealing therapy" for children with cerebral palsy (the full name is "point plus acupoint drug injection therapy"), and the hospital claimed to evaluate 381 children. The results showed that 190 cases, that is, nearly half, were normalized.

　　On October 21st, an article questioned the "needle sealing therapy" invented by Wan Guolan, the founder and honorary director of the Children’s Rehabilitation Department of the Third Affiliated Hospital of Zhengda, and the "needle sealing therapy" was pushed to the forefront. Sun Yong ‘an, chief physician of the Department of Neurology, Peking University First Hospital, said that "needle sealing therapy" is more of a gimmick, and even if it is effective, its effect is limited. Nerve injury is generally caused by congenital development or acquired injury. If it is cerebral palsy caused by poor nerve development in the embryo, even if there is some growth compensation, it is still difficult to completely cure it.

　　Cerebral palsy is difficult to treat, and there is no standard single treatment. Some experts said that we should not arbitrarily think that all self-created therapies are ineffective. Because medicine is a practical subject, it is advancing through constant exploration and trial, and some new therapies really need to break through the routine. However, the technology applied in clinic should be universally recognized and supported by evidence-based medicine. To carry out a clinical trial, first of all, the institutions involved and the researchers involved in the trial must have the qualifications to carry out clinical research; Second, it is necessary to carry out strict registration and filing, and strictly design the test plan, demonstration and modification; Third, it should be recognized by clinical trial management institutions and ethics committees; Fourth, the subjects should have the full right to know, the experimenter should ensure the safety of the subjects, and the subjects have the right to withdraw at any time during the treatment. As for the efficacy of the new therapy, it also needs a large sample of randomized double-blind controlled studies to verify it.

　　nine

　　At the dawn of treatment, "small molecular glue" can devour the pathogenic protein of Huntington’s disease

　　Involuntary dance-like movements, cognitive impairment and mental abnormality … … Huntington’s disease is one of the four major neurodegenerative diseases. Because the biochemical activity of the mutant Huntington’s protein (mHTT) causing the disease is unknown, it can’t be targeted. The traditional method of blocking the activity of the pathogenic protein by blocking agents is not suitable for the treatment of the disease.

　　At the end of October, researchers from Fudan University published their achievements in Nature, and found a "small molecular glue" that "devours" Huntington’s disease-causing protein through screening based on compound chips and cutting-edge optical methods, which is expected to bring new dawn to the clinical treatment of Huntington’s disease.

　　In the study, the team focused on controlling autophagy, an intracellular protein degradation pathway, to effectively reduce the level of mutant Huntington protein. In order to solve the problem of "self-injury", the team imagined to invent a kind of "small molecule glue", which can aim directly at the bull’s-eye, firmly stick LC3 and pathogenic protein (or other pathogenic substances) together, and then wrap the pathogenic protein into autophagy bodies for degradation. After screening, purification and a series of cell experiments, the research team obtained four kinds of "small molecular glues" that can bind LC3 and mutant Huntington protein.

　　According to team member Lu Bojun, at least two of these four compounds can cross the blood-brain barrier and directly reduce the level of mutant Huntington protein in the cerebral cortex and striatum of Huntington’s disease mice through low-dose intraperitoneal administration, without affecting the level of wild-type Huntington protein in brain tissue, and also improve the disease-related phenotype, which provides a breakthrough point for the development of oral or injection drugs for Huntington’s disease, and is expected to be applied to motor coordination disorders, facial twitching and muscle spasms.

　　10

　　"Aristocratic Drugs" Self-devalued Medical Insurance Drug List Negotiation to Reduce Patients’ Burden

　　Only when good drugs enter medical insurance can people finally get benefits.

　　In December, the National Health Insurance Bureau released the National Drug List of Basic Medical Insurance, Work Injury Insurance and Maternity Insurance in 2019 (hereinafter referred to as the Drug List). The results showed that 97 of the 150 negotiated drugs were successfully negotiated, and the average price dropped by 60.7%. This is also the largest since the establishment of the medical insurance system in China, with remarkable results.

　　During the negotiation, the National Medical Insurance Bureau spared no effort in bargaining. Take the shortlisted hepatitis C drugs as an example, four companies directly measure the quotation on the spot, and the quotation of each drug should be accurate to two decimal places. There are two quotations in total. If both of them fail to reach the psychological price of the medical insurance bureau, or exceed 15% of the medical insurance payment standard, they will be directly out. In the end, Ledipaviso fosbuvir tablets from Gilead Scientific Company, fosbuvir patavir and Elba Wegera Rive tablets from Merck were selected with an average decrease of 85%.

　　Xiong Xianjun, director of the Department of Medicine Management of the National Health Insurance Bureau, said that the significant reduction in drug costs is one of the results of this negotiation. By giving play to the role of the medical insurance department as a "strategic buyer", the drug costs will be greatly reduced by changing the price. A number of world-renowned "noble drugs" have been marked with "civilian prices", and imported drugs have basically given the lowest price in the world. It is conservatively estimated that through negotiation of price reduction and medical insurance reimbursement, the personal burden level of patients will be reduced to less than 20%, and individual drugs will be reduced to less than 5%.

Source of data: Shenzhen Cross-border E-commerce Association’s creativity/photo courtesy

Securities Times reporter Chen Xiachang

A few yuan a set of wearable nail art, a baby cloth book in 10 yuan, an electronic watch in 20 yuan, and solar outdoor lighting in 300 yuan … These are the products displayed by many merchants at the "Cross-border E-commerce+Industry Belt" activity site in Guangdong Province recently. On the same day, hundreds of cross-border e-commerce sellers and cross-border e-commerce platforms conducted face-to-face docking.

On-site merchants told the Securities Times that most of these goods will be sold around the world through cross-border e-commerce platforms. The cross-border e-commerce channel monopolized by Amazon a few years ago is now being replaced by many Chinese cross-border e-commerce platforms such as AliExpress and SHEIN.

According to data released by the General Administration of Customs, the import and export of cross-border e-commerce in China in the first quarter was 577.6 billion yuan, an increase of 9.6%. After years of development, cross-border e-commerce, a new format, together with general trade and processing trade, constitutes three major trade modes in China and has become a new kinetic energy to stimulate foreign trade growth. While the scale of cross-border e-commerce has expanded, a number of new-generation cross-border e-commerce platforms have developed rapidly in overseas markets and become "Chinese forces" that cannot be ignored. Nowadays, these cross-border e-commerce platforms have been expanding their global market share and become a new choice for global consumers to shop.

Why did the Chinese e-commerce platform rise?

Among many cross-border e-commerce platforms, the TikTok Shop launched by SHEIN, Pinduoduo’s Temu, AliExpress and ByteDance’s TikTok is the most eye-catching, and is called "Four Little Dragons" by the industry.

According to the report released by the market analysis organization Data.ai at the beginning of the year, SHEIN won the global shopping APP download champion again in 2023. On this list, Temu and AliExpress ranked second and ninth. Amazon, the American e-commerce giant, ranked third.

Before 2020, the overseas cross-border e-commerce platform represented by Amazon will become the first choice for sellers in China with a large number of overseas users. But Amazon’s massive titles to China sellers changed the whole ecology. Since April, 2021, Amazon has continued to seal up the accounts of China sellers who violate the rules, and many head sellers have been closed and their funds frozen.

A seller who once opened a 3C store in Amazon told reporters that he violated Amazon’s relevant policies by guiding users to evaluate products, and the store was finally closed by Amazon.

Then he turned to Ali’s AliExpress, and the effect was good. Next, he plans to open a shop in Temu, hoping to return to the American market.

Although the large-scale titles of Amazon have improved the standardization of the whole industry, it has also made many China sellers realize that they can’t put all their eggs in one basket. They urgently need to find a new platform to share risks.

In 2022, Temu and TikTok Shop were established successively. SHEIN, which has been operating overseas for many years under its own brand, was officially opened to third-party sellers, attracting third-party sellers to join and rapidly expanding its scale. Together with Alibaba AliExpress, which has been operating in Europe and America for many years, the Chinese cross-border e-commerce platform entered the field of vision of China sellers.

"Four Little Dragons" have their own characteristics.

The "four little dragons" can rise rapidly, and each has its own "trick".

Temu, which was established in September, 2022, became a shining star in the cross-border e-commerce industry with its parent company, Pinduoduo, who has been deeply involved in the field of affordable e-commerce for many years, and with ultra-low-priced goods and generous advertising promotion.

"Cheap" is Temu’s trademark. According to a report from JPMorgan Chase, according to the statistics of randomly selected commodities, the average price advantage of Temu is less than 20% for high-priced/brand commodities with a price higher than $30, and the average price discount of Temu is more than 50% for commodities with a price lower than $10.

According to the data of the third-party organization Sensor Tower, from September 2022 to November 2023, the global download volume of Temu exceeded 300 million times. In 2023, Temu successively entered the markets of Southeast Asia, Japan and South Korea, and launched sites in Korea, Mexico, Chile, Israel and Malaysia.

"In terms of the global business of the Group, Temu has entered 50 countries and regions since it was launched in September 2022." At the fourth quarter performance exchange meeting in Pinduoduo in 2023, Chen Lei, Chairman and Co-CEO of Pinduoduo, revealed.

Another trump card of Temu is to take the lead in adopting the full custody mode for platform sellers, that is, the merchants are only responsible for loading the goods, and the platform is responsible for the whole process from product selection to performance to sales.

Ning Fujie, an analyst at Zheshang Securities, believes that the full custody mode basically solves the problems of gray production, empty packages and fake goods. For sellers, full custody is also a way with the lowest cost of measuring money and trial and error. Under the strict price comparison, horse racing and marketing mechanism, the purchase price of Temu is lower than that of major platforms.

Compared with the birth of Temu, the veteran e-commerce company SHEIN is telling more new stories.

Founded in 2012, SHEIN mainly sells women’s fast fashion related categories in overseas markets. In the domestic market, SHEIN has always been a very low-key presence. It was not until the epidemic period that overseas users accelerated online consumption, the frequent appearance of SHEIN on foreign APP download lists, and its repeated breakthroughs in valuation attracted domestic attention. At present, SHEIN has developed into a super unicorn enterprise with a valuation of more than 60 billion US dollars.

Yang Renwen, director of Guohai Securities Research Institute, believes that SHEIN’s rise in overseas markets lies in its "flexible supply chain+high-frequency innovation and cost performance+public and private domain marketing". SHEIN’s operation process is that the back-end data center quickly updates and tests products according to big data analysis, and the supplier adopts the mode of small order and quick reaction, and quickly responds according to the sales situation of goods, chasing orders for explosive products, or modifying and retesting non-explosive products, relying on this efficient iterative rhythm to maintain the output of explosive products. In addition, the company’s marketing method of combining public and private domains not only ensures the acquisition of new customers, but also promotes user activity and realizes the long-term growth of brand value.

Since 2023, SHEIN has continuously deepened its platformization strategy, faced the global market, invited more third-party sellers to settle in, and gradually formed a "self-operated brand+platform" dual-engine development model.

The relevant person in charge of SHEIN told the reporter that unlike the traditional e-commerce platform, SHEIN emphasized the deepening of the platform model, including agency operation and independent operation. Under the agent operation mode (similar to the full custody mode of Temu), SHEIN provides one-stop empowerment and services, including commodity operation, warehousing, logistics, customer service and after-sales. In the autonomous operation mode, sellers can operate independently, including self-management of product selection, shelving, marketing strategy, sales, inventory, logistics, etc. SHEIN proposed to support brand building by relying on platform resources and brand influence.

Shenzhen Cross-border E-commerce Association has analyzed the advantages of the "Four Little Dragons" and the traditional giant Amazon. The association believes that AliExpress is outstanding in logistics, market and user coverage; SHEIN is a fast fashion company. Its main advantages are a strong digital supply chain system and a large number of young users and brand loyalty accumulated in the early stage. TikTok Shop has TikTok’s global mass user base, which stimulates users to place orders through short videos to plant grass products and live broadcast and key opinion leaders (KOL). Temu, on the other hand, focuses on the low-cost strategy, and quickly accumulates a large number of users by social fission to seize the market.

Arel, executive president of Shenzhen Cross-border E-commerce Association, said in an interview with the Securities Times that after the success of Temu’s full hosting model, the most mainstream cross-border e-commerce platform in China has embraced the full hosting model. At present, this model is continuing to be promoted and practiced in the global mainstream e-commerce platforms, which is unstoppable, greatly expanding the influence of cross-border e-commerce products in China overseas.

According to the customs statistics of Shanghai Pudong International Airport, the number of export declarations of Pinduoduo, TikTok and SHEIN3 through Shanghai Airport Port in 2023 increased by more than 10 times year-on-year.

Behind the triumphant March

Controversy continues

The Chinese-funded cross-border e-commerce platform has made great strides overseas, but it has also attracted a lot of controversy.

Take Temu as an example. Many sellers complain about Temu’s full hosting model, mainly focusing on Temu’s price reduction. Many sellers in Pinduoduo told reporters that Temu has a strict price review mechanism. If the seller’s quotation on Temu is higher than the price of similar products of domestic wholesale e-commerce company 1688, the platform will let the seller re-quote, and the subsequent goods preparation process can only be carried out after the verification price is passed. Because of the strength of the platform, most enterprises can only choose "tolerance".

In addition, under the full hosting mode, the long logistics time also restricts the development of the platform.

Deng Wenhui, an analyst at Guolian Securities, believes that the price advantage of Temu in full custody mode is obvious compared with Amazon, but the logistics timeliness is poor. According to her sampling survey on the prices of various commodities on the two platforms of Temu and Amazon, the prices of commodities with less than $10 on Temu platform and similar commodities on Amazon platform are about 2-3 times that of Temu. However, in terms of delivery timeliness, according to the official disclosure of Temu, it takes about 8-12 days for free standard delivery and 5-9 days for fast delivery of fees. Because Amazon has a local warehouse to stock up in advance and a strong logistics system, the delivery time in the United States only takes about 2 ~ 3 days.

The rapid development of Chinese-funded cross-border e-commerce platforms has inevitably moved the "cakes" of many national local platforms.

Taking South Korea as an example, the development of both AliExpress and Temu in the Korean market has shown a strong growth trend this year. As of March, the users of the two platforms in Korea were 8.88 million and 8.3 million respectively, second only to the Korean e-commerce giant Coupang. However, according to Yonhap News Agency, relevant Korean institutions are investigating the collection and use of personal information on cross-border e-commerce platforms in China. Previously, AliExpress had been inspected by KFTC, the Korean antitrust regulator, because of the increase in consumer complaints in Korea. There are indications that the South Korean government is stepping up its supervision of cross-border e-commerce platforms, which can be regarded as a protective measure for domestic enterprises to some extent.

Arel suggested that in 2024, cross-border e-commerce sellers should pay more attention to and invest in new global markets such as Southeast Asia, the Middle East, Russia, Africa and Latin America. Compared with the European and American markets with many sellers and fierce competition, emerging markets with rapid growth and great potential in 2024 will bring new performance growth points to cross-border sellers. In addition, with the sharp increase in compliance costs in Europe, Brazil, Southeast Asia and other markets, compliance in 2024 will be the primary issue that cross-border sellers must pay attention to.

　 　　　autumn fruits

　　"Taking advantage of the summer vacation, secretly becoming beautiful", "Double eyelids successfully landed and made a stunning appearance at school" … … During the summer vacation, some high school graduates and college students will include medical beauty plastic surgery projects such as double eyelid cutting, water-light needle and photon rejuvenation in their summer plans. Relevant departments reminded that medical beauty is different from general disease diagnosis and treatment, with great risks and uncertainties, and it is also easy to cause medical disputes. Therefore, consumers who need medical and aesthetic services need to improve their cognitive ability and make rational and moderate consumption.

　　The summer plastic surgery craze for minors has been going on for many years, and there are related reports and risk reminders every year. Different from previous years, this year’s media reports have a relatively novel perspective — — The risk of plastic surgery for minors is expounded by plastic surgeons persuading minors who ask for plastic surgery in hospitals. For example, a plastic surgeon in a 3A hospital in Shenzhen said that during this summer vacation, he advised three or four minors every day on average.

　　Doctors dissuade minors, first of all because minors are at great risk of plastic surgery. Minors are not yet mature. After the filler is implanted into the body, the body will develop again, and there will be phenomena such as improper size. For example, rhinoplasty is just right now, and after a few years, the child’s nasal cavity will grow and the nose will become crooked. Minors are also immature and lack judgment. If they follow the trend of plastic surgery, their ideas will change when they grow up. For example, if they cut their double eyelids now, they may think that single eyelids are more suitable for them in the future, and there will be no chance to repent. Surgical anesthesia, vascular embolism and infection will bring unbearable risks to minors. The aesthetics and values of minors will also be affected by the younger age of plastic surgery.

　　Plastic surgery is profitable, and it is common to charge tens of thousands of yuan for an operation. For most medical and aesthetic institutions and plastic surgeons, how can the opportunity to make money delivered to the door be shirked? It’s not common for doctors to dissuade them. On the contrary, many doctors not only don’t dissuade them but also encourage them. For example, the advertisements of physical beauty institutions only fail to mention the risks, misleading the consultants on the spot, posting grass stickers on the Internet, and draining medical beauty anchors in the live broadcast room, all of which are deliberately creating appearance anxiety and inducing beauty seekers, including minors, to do unnecessary medical beauty plastic surgery.

　　The further risk is that beauty loans, recruitment fraud, etc., once combined with illegal cosmetic surgery, will cause secondary or even tertiary harm to minors in many aspects, such as body and economy. Moreover, these frauds are mainly aimed at students who have just left campus, are short of money, and are planning to find a job. If inexperienced students are not alert to this, they will easily fall into the trap carefully designed by scammers.

　　The doctor’s initiative to persuade is commendable, but this "firewall" is difficult to play its role because it is rare. In particular, we should see that under the doctor’s persuasion, the risk of plastic surgery for minors can not be overcome, and the excessive plastic surgery or plastic surgery after deliberate misleading will significantly increase the risk again, and fraudulent acts such as "beauty loan" will be mixed in, and multiple risks will be formed. superposition.

　　The chaos of plastic surgery is worthy of vigilance, and the greater and more risks of plastic surgery for minors are particularly worthy of vigilance; Supervision should focus on minor plastic surgery, and minors and their parents should have a clear understanding. It’s cheat people’s best way to get rid of plastic surgery before it’s too late. You don’t have to worry that plastic surgery will "lose at the starting line" if it’s too late. What’s more, you should worry that premature plastic surgery may "ruin the starting line" for children.

Special feature of 1905 film network　On January 1st next year, the newly published Civil Code of People’s Republic of China (PRC) will be officially implemented. This also means that the "cooling-off period of divorce" which has caused heated discussion before will have legal effect in the form of express clauses in the Civil Code.

Excerpts from the Civil Code of People’s Republic of China (PRC)

Article 1077 If either party is unwilling to divorce within 30 days from the date when the marriage registration office receives the application for divorce registration, it may withdraw the application for divorce registration from the marriage registration office.

Within 30 days after the expiration of the time limit specified in the preceding paragraph, both parties shall personally apply to the marriage registration office for a divorce certificate; Those who fail to apply shall be deemed to have withdrawn their application for divorce registration.

Since the proposal stage, this "renewal period" attached to divorce has set off a discussion upsurge among netizens."It’s not’ free’ to want a divorce?" "Divorce should be calm, it is better to be calm before marriage" … … Many viewpoints collide fiercely, and the "divorce cooling-off period" has become the "divorce frying pan period".

However, Su Qin, an emotional expert who is a guest of Today’s Film Review, has a more comprehensive and long-term view on this "divorce cooling-off period" that seems to be contradicted by the whole network."Each of us has a completely different mentality when facing marriage." From the unfortunate family emotional relationship she witnessed, she saw not only the absolutely irreparable rupture, but also the regret caused by the lack of marriage education. In real life, it is often the film and television work … …

Forget about your trip.

Let the impulsive bullets fly for a while

Let everyone remember "What Mei Ma" and "Pruning Mei", but the original intention is to discuss how love is "not".When the relationship between husband and wife with Ma Dongmei is tense, a middle-aged down-and-out man, Charlotte, opens a "door" and begins a "crossing" journey back to the past … …Wow, isn’t this the immersive experience of "divorce cooling-off period"

In the "dream", Charlotte braved the wind and waves all the way with the knowledge of the "future", not only became a pop superstar, but also married Qiu Ya, the "goddess" that she couldn’t touch when she was a student.Ma Dongmei, who still exists, is just an ordinary "strong fan" who silently infatuates with and guards him.

The only warmth that Charlotte felt before the tragic end of her virtual life was a bowl of fennel noodles with gravy made by Ma Dongmei.The so-called empty dream of making up for "regret when I was young" finally made Charlotte, who had lost her way, return to her original heart of falling in love with Dongmei. Of course, this circuitous expression of "regret" also has a realistic refraction in Su Qin’s daily work. "In the case of remarriage, the initiative to propose is that men are mostly."

Under Su Qin’s interpretation, Charlotte’s transformation or self-help of marriage is the contribution of "divorce cooling-off period" subconscious review. Of course, in her view, goodbye mr. loser still has the defect of unilateralism — — Throughout the discussion of marriage relationship, it is centered on the man Charlotte, while the woman Ma Dongmei is only a supporting role that endures from beginning to end.

"If Ma Dongmei can also have a review or reflection, I think it may be more perfect." It is not uncommon for women to work hard but not complain. Their grievances and impulses in marriage life are also worthy of in-depth discussion.

In a sense, "the cooling-off period of divorce" is often a buffer for "passionate divorce". In Su Qin’s experience, passionate divorce often happens between young couples who are not married long. "They are actually led by emotions, not emotions. After leaving in the morning, they go back on their word in the afternoon."

Wu Xiaojiang and Li Nan, a young couple played by Qiao Shan and Huo Siyan, are on the verge of breaking up their marriage because of a phone call game.

In fact, the "game" itself is just an introduction, and the lack of daily communication with each other is the absolute factor that triggers the divorce impulse; And this kind of "mistake" deserves a chance to "make up" for those who really love each other.

In modern society, gaining and losing are sometimes too easy, so that lovers may talk about "breakup" and "divorce" by the way. This kind of "true temperament" may not be fair to two people who still have enough emotional foundation. Impulsive "bullets" might as well fly for a while in the "cooling-off period of divorce".

Shake your hair and walk away.

No difference between hot and cold, zero tolerance for violence

As for marriage, many China audiences have had "fear" since childhood, mainly from the gentle at home and the tyrannical Anjiahe at home in the TV series Don’t Talk to Strangers.

What makes many netizens uneasy about the "cooling-off period of divorce" is also related to violence: do victims of domestic violence have to endure another month’s injury?

The most direct sustaining factor of marriage is still emotion. The "divorce cooling-off period", which is also based on emotional considerations, will naturally not be absolutely framed.

Excerpts from the Civil Code of People’s Republic of China (PRC)

Article 1079 If a spouse requests a divorce, the relevant organization may mediate or directly file a divorce lawsuit with the people’s court.

When trying divorce cases, the people’s court shall conduct mediation; If the relationship has indeed broken down and mediation fails, divorce shall be granted.

In any of the following circumstances, if mediation fails, divorce shall be granted:

(1) Bigamy or cohabitation with others;

(2) committing domestic violence or abusing or abandoning family members;

(three) gambling, drug abuse and other bad habits;

(four) separated for two years due to emotional disharmony;

(five) other circumstances that lead to the breakdown of marital relationship.

If one party is declared missing and the other party files a divorce lawsuit, the divorce shall be granted.

After the people’s court has ruled that divorce is not allowed, and the two parties have separated for one year, if one party files a divorce lawsuit again, divorce shall be granted.

The behavior of "domestic violence" explicitly pointed out in situation (2) obviously does not exist in the mediation scope of "cooling-off period". However, Su Qin reminded the relieved friends in time: the damage caused by "cold" violence is no less than that caused by externally publicized violence.

Let’s turn our attention back to the movie "The Phone Rings". Among them, Tian Yu and Lele Dai, the middle-aged Kochi couple, loved each other before and presented a model family appearance, but when they got home, they didn’t even say a word to each other.

"This is a typical cold violence." According to Su Qin’s observation, the mode of no-hands-on, polite and peaceful communication is the reality of many families in China. The phrase "for the children" seems to be that the marriage is only maintained to give the children a stable illusion.

In fact, it is these subtle changes in the family atmosphere that children in the growth period are best at capturing and most susceptible. In the movie, Wu Wenxue and Zhang Yan, who were not "taken away" by the light because of the disappearance of their love, had already been discovered by the daughter played by Vicky Chen.

Until the end of the film, the couple, played by Bo Huang and Tan Zhuo, are still "tender". Their daughter, however, has already won the love around her through retaliatory puppy love."These parents are selfish," Su Qin bluntly said. This kind of struggling "living together" will bring huge psychological burden to the children. "In this case, I will say to the children: Son, this matter really has nothing to do with you, but your parents haven’t grown up yet."

Perhaps we still remember the scene at the end of the movie where Scarlett Johansson plays the role of tying the shoelaces of her ex-husband. With the emotional ties that naturally lead to the formation of family memories, they have also experienced the psychological mediation process of "divorce cooling-off period", but the verbal and mental torture and harm to each other before are still irresistible.

Get together sometimes. Any form of violence deserves a zero-tolerance decision to walk away.In the face of the "cooling-off period of divorce", many people focus on the "period" of 30 days, ignoring the "cooling-off" that should really be the necessary support in emotional relationships — — The choice between dispelling impulse or being firm and discrete should be calm enough.

Movies bearing joys and sorrows may give you support and answers.

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　 　 　 　 How does WeChat activate China Unionpay Quick Pass function? Introduction of WeChat applet supporting China Unionpay Quick Pass payment method

　　　　　　Ordinary users of China Unionpay Quick Pass function can’t open it on WeChat. Only when merchants open China Unionpay Quick Pass payment, users can use China Unionpay Quick Pass to pay in small programs.

　　　　　　Merchant opening steps:

　　　　　　Log in to the backstage of WeChat payment merchants-> Product Center-> Development Configuration page, find "Payment Method Configuration" at the bottom, and click "Open". There is no need for any additional configuration. After opening, as long as the user’s mobile phone is equipped with China Unionpay Quick Pass app, they can choose to pay in China Unionpay Quick Pass when paying for the applet.

　　　　　　Steps for users to pay with China Unionpay Quick Pass:

　　　　　　1. When the merchant opens China Unionpay Quick Pass, when users make payment in the applet, two signs, WeChat Pay and China Unionpay Quick Pass, will be displayed below, and click China Unionpay Quick Pass.

　　　　　　2. Click Allow according to the page prompts, and then you can jump to China Unionpay Quick Pass app.

　　　　　　3. Finally, click to confirm the amount and click Pay Now.