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　　On January 21st, the results of the second batch of centralized drug procurement organized by the state were released, and 32 varieties were successfully purchased, with an average price drop of 53% and the highest drop of 93%. Many drugs selected this time are commonly used by ordinary people, involving diabetes, hypertension, colds and fever, etc., and more patients will benefit.

　　The commonly used drugs such as Baitangping for diabetics, indapamide tablets for hypertensive patients and acetaminophen for colds and fever have been reduced by more than half!

　　On January 17th, under the guidance of the National Medical Insurance Bureau and other departments, all provinces (autonomous regions and municipalities) and Xinjiang Production and Construction Corps formed a procurement alliance, and the second batch of centralized procurement of drugs organized by the state was carried out in Shanghai, resulting in the result of quasi-winning. 32 varieties were successfully purchased, and compared with the lowest purchase price in the alliance area in 2018, the average selected price decreased by 53%. On January 21st, the result of the election was officially released.

　　The highest drop in drug prices reached 93%

　　Of the 33 varieties collected this time, 32 were successfully purchased, and a total of 100 products were selected. 122 enterprises participated, resulting in 77 enterprises to be selected. Compared with the lowest purchase price in the alliance area in 2018, the proposed bid price dropped by an average of 53%, with the highest drop reaching 93%.

　　After this round of centralized collection, it means that there are more commonly used drugs to reduce prices, that is, 25 drugs selected before, and 32 varieties this time. The 32 varieties contain many drugs that people are familiar with, such as acetaminophen, antibiotics amoxicillin, clindamycin hydrochloride, azithromycin and cefradine, acarbose and glimepiride for diabetes, metronidazole tablets for toothache, indapamide tablets for hypertension and bisoprolol fumarate. The price reduction of these commonly used drugs will benefit more patients. For example, Bayer Acarbose Tablets (50mg30 tablets), the original drug, with the trade name of Baitangping, is used in a very large amount among Chinese diabetics. This quotation is 0.18 yuan per piece, with a drop of more than 90%.

　　On the 17th, 122 of the 33 enterprises preparing to purchase varieties declared their prices, including the original research drugs and generic drugs that passed the consistency evaluation. Four original drugs were significantly reduced in price, and they were successfully shortlisted for the selected results.

　　This centralized procurement is still the general idea of "national organization, alliance procurement and platform operation", adhering to the principles of purchasing with quantity, integrating recruitment and procurement, and ensuring use, and taking conformity evaluation as the condition for the shortlisting of generic drugs. Medical institutions and retail pharmacies designated by medical insurance can participate voluntarily.

　　"The second batch of state-organized centralized purchasing manufacturers can be multiple, up to six, maintaining moderate competitiveness. According to the number of selected manufacturers, the dosage is agreed to be 50% to 80% respectively. At the same time, maintain a reasonable price gap between different selected enterprises for the same drug. Among the short-listed manufacturers to be selected, the lowest quotation is given priority to two regions to ensure the dosage and protect the enthusiasm of enterprises. " Ding Jinxi, a professor at China Pharmaceutical University said.

　　In the next step, all localities will focus on the implementation of the selected results, and patients are expected to use the selected drugs from April this year.

　　Guaranteed dosage of low-priced drugs

　　In the "4+7" pilot project, the original drug appeared "patent cliff" for the first time, and the price was greatly reduced. This collection was not unexpected. For example, the price of acarbose, Bayer’s diabetes drug, was reduced by more than 90%, and meloxicam tablets, Boehringer Ingerham’s drug for rheumatoid arthritis, was reduced by more than 80%.

　　However, some drugs that were originally low-priced in history have returned to low-priced positions in this collection, and the dosage has been guaranteed to ensure a stable supply. For example, acetaminophen is 0.03 yuan per tablet, metronidazole is 0.05 yuan per tablet, and amoxicillin is 0.05 yuan per tablet.

　　These prices are just a few cents, but they are not generally used by people. This is because for the convenience of bidding, enterprises quote in the smallest unit of preparation (tablets, granules, sticks and bags), while in real life, people pack drugs in boxes, bottles and other units. For example, the centralized purchase of acarbose from an enterprise, the proposed bid price of 0.18 yuan is the price of each tablet, while patients buy it in boxes, and the converted price is 5.42 yuan per box.

　　So, are these prices higher or lower than international prices?

　　Guangdong dongyangguang pharmaceutical co., ltd, in this centralized procurement, three products were shortlisted, and two products were ranked first, which was the lowest among the prices to be selected for this variety. Two products to be selected are moxifloxacin hydrochloride and olmesartan medoxomil, which were originally sold abroad and just listed in China. Among them, the proposed bid price of moxifloxacin hydrochloride is 6.66 yuan.

　　According to Chen Yangui, the executive director of the company, the centralized purchasing organized by the state has made the market return to rationality. The company has strong technical force and strong supply chain, and it has great advantages to return to the domestic market, so it participated in the second batch of centralized purchasing. "The quotation for the shortlisted qualification is similar to that in the European and American markets."

　　Inquire about the price of moxifloxacin hydrochloride of the same specification abroad, and the public price is RMB 8 yuan and 9 yuan. Feng Chang, a professor at China Pharmaceutical University, explained that the actual settlement price is often lower than the public price, and China has a large market share, so there is not much difference between the two. "Enterprise quotation has its own development strategy considerations, which are normal market behaviors."

　　Some experts estimate that in the past, the price of generic drugs in China was more than twice the international price. After purchasing with quantity, it returned to the international normal price. Expert research has found that the part that is higher than the reasonable price occurs in the intermediate link, which is not included in the quality links such as production and research and development. Squeezing out this part of water will not affect the quality of drugs, nor will it affect the development of enterprises.

　　An original research drug of Boehringer Ingerham, which has been on the market for more than 20 years, entered the scope of the proposed selection this time. The drug has already passed the patent period. Although the price has been reduced by 80%, the company originally sold it mainly in Shanghai, Beijing and some provincial capitals. After entering centralized purchasing this time, the sales market has expanded to half of China. "We actively participate in and cooperate with China’s national policies." Zeng Chenghui, head of the company’s regional expansion business department, said.

　　The person in charge of the National Pilot Office and the Joint Procurement Office believes that the main reasons for the sharp price reduction of selected drugs are as follows: the state organizes centralized procurement and use of drugs, which truly realizes the integration of procurement with quantity and recruitment, and gives clear expectations to pharmaceutical manufacturers, which is conducive to their independent quotation and declaration according to the purchase volume, squeezing out unreasonable virtual space; Further improve the procurement rules, and realize the function of market price discovery through open and sunny competition; Timely settlement of payment for goods significantly reduces the capital cost of enterprises and leaves room for price reduction.

　　By purchasing with quantity and ensuring the use, enterprises no longer need to carry out sales public relations, "a batch of low-priced drugs ‘ Resurrection ’ It is also a return to international practice. " The person in charge said.

　　The burden on patients is significantly reduced.

　　According to the person in charge of joint procurement, the "4+7" pilot project and expansion are progressing smoothly.

　　The implementation of procurement in pilot cities exceeded expectations and the agreed procurement volume was completed ahead of schedule. By the end of December 2019, the average procurement progress of 25 "4+7" pilot areas for selected drugs was 183%, and the selected drugs accounted for 78% of the purchases of drugs with the same generic name. All the expanded areas have started to implement the results of the expanded procurement in December, and patients all over the country have used the drugs selected by centralized procurement with high quality and low price.

　　Due to the sharp drop in prices, the burden on patients has been significantly reduced. In addition, judging from the situation in the "4+7" pilot areas, the proportion of people using generic drugs and original drugs that have passed the consistency evaluation has greatly increased from about 50% to over 90%, which has significantly improved the quality level of people’s drug use.

　　Chen Qiulin, director of the Social Security Research Office of the Institute of Population and Labor Economics of China Academy of Social Sciences, said that the centralized drug procurement organized by the state is different from the previous recruitment, and it is beneficial to patients, doctors, enterprises, medical insurance funds and other parties, forming a benign mechanism. "Centralized procurement based on the consistent evaluation of quality and efficacy has prompted enterprises to return to cost and quality competition and fundamentally improved the ecological environment of the pharmaceutical industry. At the same time, it becomes a push ‘ Three medical linkage ’ The important entry point, policy connectivity and synergy, play a superposition effect. "

　　The person in charge of the pilot office said that the next step will be to establish a normalized and standardized centralized procurement system based on the improvement of the "4+7" pilot and expansion and the experience of the second batch of countries in organizing centralized procurement and use of drugs, and to include more products in centralized procurement. "Let the new procurement model, marketing method and industry ecology become the leading forces."

　　According to Ding Yilei, deputy director of the Price and Procurement Department of the National Medical Insurance Bureau, the scope of centralized procurement was fully covered, and the varieties with sufficient competition and stable supply were selected for one tender and national implementation, and the rules were further improved. "In the future, according to the practice of this round of centralized procurement, the centralized procurement of drugs organized by the state will be normalized, and qualified varieties will be included in the scope of centralized procurement." (Our reporter Li Hongmei.)

At 23: 30 pm Beijing time on October 29th, the 10th round of the 2023-24 Premier League ushered in the first Manchester City Derby of this season, and Manchester United played against Manchester City at Old Trafford Stadium. In the first half, Hoyle pulled Rodley down and sent a penalty, and Harland took the penalty and hit it; In the second half, Harland scored twice with another goal, and before the end, he assisted Foton to seal the victory. Onana made many dives in the audience. In the end, Manchester City beat Manchester United 3-0 away.

This game is the 191st Manchester City Derby in history. Before the game, a series of activities were held at Old Trafford Stadium to commemorate the legendary Sir Bobby Charlton.

In the second minute, Manchester United stole the ball in midfield, and McTominay took the ball to the front of the penalty area and shot it with his left foot. The ball was not strong enough for Edersen. In the 8th minute, Rodley in the frontcourt hoisted the ball into the right side of the penalty area, Walker put it in front of the baseline and knocked the ball across the middle. Foden’s header was saved by Onana.

In the 12th minute, Grali took the ball to the left side of the penalty area, but he passed it back to his opponent in an inverted triangle. Hoyle took the ball and pushed it forward. Unfortunately, his teammates responded too slowly, and the fast break turned into a sports war. In the 15th minute, Foton sent a straight plug from the midfield, and Onana rushed out of the penalty area to clear the ball before Harland did.

In the 20th minute, Manchester City kicked the left tactical corner, Grali grabbed the ball from the right side of the restricted area and shot the far corner, and Onana saved the ball.In the 26th minute, Manchester City won a free kick in the frontcourt, and the ball was hoisted into the penalty area. Rodley, who was fighting for the landing point, was pulled down by Hoyle, and the referee awarded a penalty after watching VAR.

The penalty was taken by Harland, who shot his left foot low in the lower right corner of the goal and tricked Onana into scoring the ball. Manchester City led Manchester United 1-0.

In the 31st minute, Manchester City made a mistake in the frontcourt return, and Hoyle got the ball and got a half-single-handed chance. After he passed the goalkeeper, he didn’t have an angle to shoot, and then he crossed the middle. Unfortunately, B shot high from a small angle.

In the 36th minute, Manchester City made a cross from the right in the frontcourt. Maguire’s header in the penalty area was on Dallot, and he was almost attacked by Grali. In the 37th minute, Manchester City got a free kick from the left outside the penalty area, and Alvarez shot directly, and Onana saved the ball.

In the 45th minute, Manchester United made a long pass from the right side of the midfield. At the top of the arc, McTominay stopped the ball and turned to volley. Edersen saved the ball with one hand. In the 45th+4th minute, Seat B made a forward pass on the left baseline of the restricted area, and Harland headed Taishan in the small restricted area, and Onana flew to dedicate himself. At the end of the first half, Manchester City temporarily took the lead.

In the second half, Yi Bian fought again. In the 48th minute, B Fei received a tactical corner kick in front of the penalty area and made a long shot. Edersen saved the ball. In the 56th minute, Grali took the ball to the far corner from the left side of the restricted area, and Onana saved the ball sideways.In the 50th minute, the B-seat caught the ball and came to the bottom line on the left side of the penalty area. Harland in the middle headed the goal. This time, Onana had no choice. Manchester City led Manchester United 2-0.

In the 58th minute, Alvarez directly blocked the left side of the restricted area at the top of the arc, and Grali made a small-angle volley, and the ball missed the far post. In the 66th minute, Seat B shot with his left foot in front of the penalty area, and Onana hugged the ball. In the 69th minute, Rachford moved forward into the restricted area, and after receiving a long pass from the midfield, he shot low from a far corner at a small angle, and the ball missed slightly.

In the 71st minute, Grali sent a straight plug in the frontcourt, and Harland caught the ball to form a single knife. His volley on the left side of the restricted area was blocked by the attacking Onana. A minute later, Lindelov and Onana’s continuous mistakes almost gave Manchester City a goal.

In the 80th minute, Rodley took the ball and made a long-range shot in front of the restricted area. Onana saved the ball sideways, Harland got the ball on the left side of the restricted area and then passed it horizontally. Foden in the middle of the road easily shoveled the empty net and Manchester City led Manchester United 3-0.

In the 82nd minute, Manchester City made a cross from the left side of the penalty area. Before the penalty spot, Foden turned his back and hit the door, and the ball only missed a little.

In the end, the whole game ended and Manchester City beat Manchester United 3-0.

Recently, Yan Ning, a famous structural biologist, announced that he would resign from Princeton University and set up the Academy of Medical Sciences in Shenzhen. In response to the latest research that she will focus on when she returns to China, she said that the discovery of structural biology is of great significance to the pharmaceutical industry, including the research on the interaction between drugs and hormones, which has more implications for drug development and disease treatment.

Yan Ning said, for example, that through the method of structural biology, scientists saw for the first time that two commonly used drugs used protein as a "scaffold", which directly "side by side" affected the normal function of protein.

Technological change promotes the development of structural biology.

Protein, as the scaffold and main substance of human tissues and organs, plays an important role in human life activities. In the cell, a large number of protein elements form the molecular machines, which performs important molecular processes in the cell through the interaction of protein, including the cell’s response to the external environment and the internal environment, and also forms a signal transduction network system with the interaction of protein as a link.

Structure By studying the three-dimensional structure, dynamic process and biological function of biological macromolecules, biology can provide more details of protein interaction and real-time dynamic process, thus helping scientists to understand molecular mechanism and explore the pathogenesis of diseases related to macromolecular dysfunction.

The development of biology not only contributes to the discovery of drugs, but also affects the research fields of life sciences including biochemistry, cell biology, genetic development, neurobiology, microbiology and pathopharmacology.

The development of science and technology has been promoting the progress of structural biology. In 2017, the Nobel Prize in Chemistry was awarded to cryoelectron microscopy, which can greatly improve the efficiency of analyzing the atomic resolution three-dimensional structure of large protein complexes; Moreover, researchers can freeze biomolecules in motion and visualize their motion process.

This breakthrough has brought a perfect storm to the field of structural biology. In recent years, important breakthroughs have been made in the field of life sciences. The work of China scientists such as Cheng Yifan, Shi Yigong, Yang Maojun and Liu Zhengfeng has also benefited from this technology. They have analyzed the important complex structure of atomic resolution. In addition, the enzyme that produces the protein that leads to Alzheimer’s syndrome was analyzed by cryomicroscope.

In August, 2015, Shi Yigong’s research team published an article in Nature, reporting the three-dimensional electron microscope structure of human γ -secretase with a resolution of 3.4 angstrom, and studying the function of the pathogenic mutant of γ -secretase based on the structure analysis, which provided an important foundation for understanding the working mechanism of γ -secretase and the pathogenesis of Alzheimer’s disease.

In February, 2020, after the outbreak of COVID-19, the research team of West Lake University successfully analyzed the full-length structure of novel coronavirus receptor ACE2 for the first time by using cryo-electron microscopy, which helped the research and development of drugs in COVID-19.

What does AI predict protein folding change?

With the help of artificial intelligence technology, DeepMind, a subsidiary of Google, recently announced 220 million kinds of protein structures predicted by AlphaFold software, which shocked the field of structural biology, because it indicates that artificial intelligence enterprises have begun to "truly hand over the power of Al to scientists all over the world".

Scientists compare the significance of this disruptive breakthrough with the human genome project. In the 1990s, when the Human Genome Project began to take shape, scientists realized that it was not enough to master the base arrangement of genes, but also to know the protein, the product of genes.

Shi Yigong, academician of China Academy of Sciences, structural biologist and president of West Lake University, commented on AlphaFold’s work: "Its accurate prediction of protein structure is the greatest contribution of artificial intelligence to the scientific field, and it is also one of the most important scientific breakthroughs made by mankind in the 21st century."

Shi Yigong once told China Business News: "AlphaFold represents the world’s leading artificial intelligence protein organization prediction system." At the same time, he said, China’s high-tech enterprises are catching up, expecting to bring surprises to the world in the near future.

He also said that the improvement of the accuracy of protein structure prediction will greatly benefit the pharmaceutical industry. "Artificial intelligence prediction of protein structure provides an important foundation for drug design and optimization. The structure of drug target proteins combined with all small molecule drugs can almost be wiped out by AlphaFold. " Shi Yigong said.

In the opinion of some scientists, although AlphaFold’s work is shocking, the accuracy of drug research and development prediction is not enough. Professor Liu Zhijie, executive director of iHuman Institute, Shanghai University of Science and Technology, told the First Financial Reporter: "It has been a long time to predict the protein structure. Now the accuracy of the prediction is definitely getting higher and higher, but it still hasn’t reached the precision of crystal structure."

Liu Zhijie First Financial News told the reporter that the crystal structure is the most accurate, and now artificial intelligence can predict the protein folding with the accuracy of electron microscope and nuclear magnetic resonance. In addition, because there are thousands of structures in protein, the difficulty of analysis is different. "If some protein sequences are similar to the known structure of artificial intelligence, it is easier to predict." Liu Zhijie said.

However, he still believes that with the continuous improvement of the prediction accuracy of protein folding, it will play a more important role in the field of life sciences in the future. "If the current prediction can reach the accuracy of electron microscope, some drugs can already be designed. Drug design is the biggest application field of artificial intelligence protein folding prediction." Said to Liu Zhijie First Financial Reporter.

Others think that with the development of artificial intelligence, there may not be so many structural biologists in the future. "Many researchers who do structural biology are actually more like technical service personnel. The more people there are, the more structures that can be analyzed. Therefore, in essence, a large part of their work depends on manpower. Now with AI, it is true that a large number of people who do structural biology have changed careers." A virus researcher told the First Financial News reporter.

However, for top structural biologists such as Shi Yigong, technology is only a powerful support for the "top brain", which can help them realize more ideas. "Every conscientious biologist should know how to make good use of the structural prediction of artificial intelligence." Shi Yigong said.

Professor Michael Levitt, winner of the Nobel Prize in Chemistry in 2013, told China Business News: "I think many structural biologists are not only doing structural research, but also doing a lot of work on protein function and drug research and development, just like Professor Yan Ning. Artificial intelligence only liberates a part of traditional manpower, but the progress of science still needs to rely on the smartest human brain. I’m afraid that artificial intelligence alone will not work. "

In recent years, a number of AI pharmaceutical companies have also been born in China. In this regard, Ewing Nan, academician of Chinese Academy of Sciences and president of Beijing Institute of Scientific Intelligence, pointed out to the First Financial Reporter: "The emergence of AI for Science research paradigm is an important historical opportunity for scientific and technological innovation, which not only expands the capability boundary of data-driven and physical model-driven models, but also is expected to promote the organic combination of the two, provide theoretical basis for further solving practical problems, and greatly narrow the distance between scientific research and practical application."

Live broadcast November 30th. According to Beiqing report, Li Tie himself recently found Chen Yiyuan, chairman of the Chinese Football Association, profoundly self -review and sincere apology.mean.

For Li Tie’s future, the Chinese Football Association will submit a report to the superior management department. After approval, it will announce the final result through official channels in December.

Li Tie brought the country’s feet this afternoon to the last outdoor training of this closed training at the Taihu Taihu Football Base in Suzhou.Subsequently, the team will take one day on December 1 and be collectively transferred to Shanghai on December 2 to receive "independent observation".Because some Chinese Super League teams have recently come to Shanghai to prepare for the Chinese Super League, some of the national football will directly meet with the club troops, and the national football coaching team will not arrange any collective training in Shanghai.

On November 30th, Beijing time, the World Table Tennis Championships had officially concluded. The final record of the National Table Tennis was to gain 4 gold medals and lost the men’s doubles championship.

Although there were no 5 gold medals, the results of Guoping are still very good, and it has also received praise from the official social media of the People’s Daily. However, Wang Manyu and Fan Zhendong, who played the best winner this time, did not be named. The only one who was named was Sun Yingsha who had lost the women’s singles championship. It turned out that she was the MVP of this year’s national table tennis, although she Did not win the most gold -content award.

《人民日报》亲自开口谈到了国乒这次的情况，并且晒出了九宫格图片，九宫格当中也是有国乒本次出征的大部分主力选手，包括孙颖莎，王曼昱，樊振东，梁靖崑，以及王楚钦和Lin Gaoyuan, Chen Meng and Wang Yidi and others.

They also accompanied: "The Houston World Table Tennis Championships ended in 2021, and the Chinese team ended with four gold results." Then he specifically designed Sun Yingsha: "Sun Yingsha World Table Tennis Championship harvested 2 gold and 1 silver. Each point is every point. Not easy, every player is good, hard, Chinese table tennis, pride for you! "

They recognized Sun Yingsha’s series of contributions, so they mentioned that Sun Yingsha’s two gold and one silver alone, which shows that Sun Yingsha is the real MVP. Wang Manyu did win, and completed the double championship and won the championship of the women’s singles and women’s doubles, but her performance was not as good as Sun Yingsha. Although Sun Yingsha said that the women’s singles won the runner -up, she was in the mixed doubles and her All the women’s double -line operations won the gold medal, and even Sun Yingsha was a third -line operation.

One day before the start of the final, Sun Yingsha even played 4 games in one day, a mixed doubles semi -final and a mixed doubles final, and there were two semi -finals of women’s singles and women’s doubles. Playing 4 games a day and remained full of victory. More importantly, Sun Yingsha defeated the Japanese team’s five giants Zhang Benzhi, Ito Makoto, Hayawa Miyu, Ishikawa Jiachun.

She defeated Hirano Miyu and Ishikawa Jiachun in the 1/4 finals of the Women’s Doubles, and defeated Ito Makoto and Haya Hina in the women’s doubles finals. Facing the Japanese five giants, people played 9 wins and 2 losses. The third -tier operations were better than Wang Manyu. She was the real MVP. Sun Yingsha.

What’s more?

Wang Manyu has only two gold medals, and the mixed doubles competition will go out early, but Sun Yingsha is 2 gold and 1 silver, so the "People’s Daily" will specifically recognize her. She is the real MVP. Only she has received such treatment. Liu Guoliang recognizes her. Normally, this is the treatment of the next Grand Slam and the National Table Tennis Demon King.

This may also be why Liu Guoliang and Li Yan will personally serve as Sun Yingsha’s coaches during this World Table Tennis Championships, find a problem for her, and give her a guest to feed her the ball. On the one hand, it is indeed because Sun Yingsha has no supervisor in charge, and on the other hand, it may be because Sun Yingsha has always been Liu Guoliang’s favorite first love general.