According to Japanese media reports, a few days ago, the idol actress Yuan Qianhui, who has attracted much attention for her role in the Japanese TV series Queen 3, held a commemorative event for the release of the latest photo album LOSVAGAS. She advertised that this work showed the ultimate sexiness and also had very cute content.

　　On the day of the event, Yuan Qianhui was wearing a short skirt in Santa Claus style. For this photo album with super exposure, she said, "It’s really very exposed, and I worked hard when shooting, showing the ultimate sexy and lovely content." Recalling her work experience in Los Angeles and Las Vegas during filming, she said: "Everything I saw was large in size, and I felt very fresh. I was very happy there and was completely captured. It took a lot of time to get back to reality." However, shooting in the desert is not so easy. Yuan Qianhui said: "I don’t know the direction of going back at all. Everyone is talking and walking, and the car is still stuck in the sand."

　　This photo album was shot in Los Angeles and Las Vegas. Yuan Qianhui looked for a theme shot in the local area, which reflected her personal style. There are super sexy clothes, and colors and styles are very cute. Looking back on this year’s achievements, Yuan Qianhui said: "I am very satisfied this year and have done a lot of things I want to do. I hope I can make greater progress as an actor next year and shoot more works. I hope I can challenge the stage play and read more books next year." Starting next month, Hara Chihiro will start filming the Japanese drama Dr. Ichiro.
　

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Wherever Hua Xizi goes, it is all oriental aesthetics.

Since its establishment, Hua Xizi has fully integrated the elements of the national tide into the brand, and at the same time, taking advantage of the live broadcast room in Li Jiaqi, it has once become a model of the rise of the national tide brand.

But on the other hand, it frequently overturned on loose powder, cleansing oil and eye shadow. Hua Xizi’s oriental makeup gift box is still "crying" for many girls in the little red book. The ancient high-end Huaxizi, which is understood, seems to be lacking in modern high-end.

Interestingly, however, the sales of Hua Xizi are still very high.

Hua Xizi’s Success Password: Guofeng Marketing Meets Li Jiaqi.

Hua Xizi was founded in 2017. "Flower" means to raise makeup with flowers, and "Xizi" is named after Su Dongpo’s "Want to compare the West Lake with the West Lake, it is always appropriate to make light makeup and heavy makeup", and "Oriental makeup, raise makeup with flowers" is also the brand concept of Hua Xizi. It can be said that Hua Xizi is full of national style from name to concept, and the element of "Oriental women" is engraved in products and marketing.

For example, concentric lock lipstick, Shouwu eyebrow pencil and Songyan butterfly feather mascara … seem to add these beautiful national style prefixes, no matter what color number or model, as long as they are used, they are "the beauty of the East". In addition to the originality of the name, Hua Xizi integrated the national style elements and techniques such as "micro-carving" into the packaging design, and introduced carved lipstick, even combined with ceramics. It can be said that Hua Xizi’s positive innovation around the national style and clear brand positioning under a certain cultural label are really lacking in old domestic products such as Perfect Diary, Appropriate Herbal Medicine and Nature Hall.

At the same time, in the choice of spokespersons, from kiku, a "four thousand-year-old beauty", to Du Fu, a supermodel with an antique appearance, to Liu Shishi, who is gentle and classical in temperament, and Charlie, who is moderately superior to the national songs, everyone has just combined with "Oriental Aesthetics".

Not only are the products and spokespersons very "national style", Hua Xizi actively promotes more and more users to participate in the discussion of national style culture through marketing efforts, such as the discussion of national style topics such as "Charlie meets Hua Xizi", "Hua Xizi’s birds fly at the phoenix" and "Oriental Romance" initiated on the network platform, supplemented by online and offline national style advertisements, and the scenery is the same for a time.

As long as there is a "national style", is it "charming" enough? The answer may be yes.

According to a survey of more than 1,000 post-80s consumers in the first-tier to third-tier cities in China by Park Rui &Credamo, the minority circle that women are most concerned about has "national style". It can be seen that from the main consumer group of the younger generation to the women who are romantic about "national style until death", as a make-up brand, Hua Xizi chooses the right path, which will get twice the result with half the effort.

In addition, on the way of Hua Xizi’s rise, one person who has to be mentioned is Li Jiaqi. At the end of September 2019, Li Jiaqi was invited to become the chief recommender of Huaxizi, and deeply participated in its product research and development. Insiders of Huaxizi Company said, "Li Jiaqi said no, this product will not pass."

In Li Jiaqi’s public live broadcast, I also "bound" myself with Hua Xizi in numerous high-profile ways, such as: "I supervised them to polish the concentric lock lipstick last year", "Hua Xizi is getting better and better under the supervision of my Li Jiaqi" and so on.

According to institutional statistics, in 2020 alone, Hua Xizi appeared 77 times in the live broadcast room in Li Jiaqi. From the sales data, it took only 16 months for Huaxizi to go from a new beauty product that was difficult to enter the top 20 in Tmall sales in 2019 to a sales volume of more than 190 million yuan in 618 in 2020, ranking first in Tmall GMV.

Next, Huaxizi is still going smoothly. According to the data, in 2021, the highest monthly sales growth rate of Huaxizi reached 89.83%, and the single brand GMV exceeded 5.4 billion yuan, an increase of 80% over the previous year, making it the first local makeup brand. In overseas markets, Huaxizi has been sold to more than 200 countries and regions around the world, with a turnover of 14 million yuan, an increase of 286% over the previous year, pushing domestic products to the world.

The dilemma of Hua Xizi: neither high-end nor cheap.

As a new domestic brand, Huaxizi takes the people-friendly route in price, and the price is mainly 100-300 yuan, which also means that it does not belong to the category of high-end beauty cosmetics. It seems that Hua Xizi is also aware of this and doesn’t want to fight the price war any more, as can be seen from his "bad" behavior in this year’s double eleventh promotion.

Compared with other make-up brands, Hua Xizi only launched preferential activities such as "full dress plus gift", "buy 1 and enjoy 3" and "buy 1 and enjoy 7", and the preferential strength is not "double eleven" at all. In this regard, the relevant person in charge of Hua Xizi revealed: "Hua Xizi’s preferential strength in the traditional e-commerce promotion node has always been small, and the brand is still long-term and will not be excessively pursued.

Not only is he unwilling to lower the price, but Hua Xizi also wants to make a breakthrough in the unit price of customers. "Why can China brands only sell cheap prices? We want to break the price ceiling. " Fei Man, co-founder of Hua Xizi, said in an exclusive interview with the media that Hua Xizi must escape low-price competition if he wants to produce products with high creativity, high technology and high investment.

Hua Xizi’s practice of breaking the price ceiling first chose the Japanese market to practice. The price of Hua Xizi’s powder cake products in Japan is around 300 yuan, and the price directly catches up with Chanel’s cake products. In China, it is also trying to increase the unit price of customers on the basis of the price system that customers are used to. For example, 520 nodes launch concentric Qi Mei suits, and 618 and New Year Festival both launch Oriental Beauty dresses, with prices ranging from 520 to 1314. The unit price of customers is increased by combining products, but domestic customers do not pay the bill.

Relying on these gift boxes, Hua Xizi was "black and red" in the little red book. Many girls who received the gift boxes called "crying in the toilet". The point that everyone vomited was mainly in the exaggeration of formal design and no cost performance. The same amount would rather receive a high-end big-name single item.

Strangely, aside from the cost performance ratio, the gift box of oriental makeup is also a beautiful story about the national style, and the design inside and outside of the gift box is also close to the "national style". Why can this national style only poke the hearts of straight men, but it doesn’t work for girls?

Perhaps it is the user’s aesthetic fatigue, or it may be more rational. But for Hua Xizi, the premise of raising the price, as Fei Man, co-founder of Hua Xizi, said, is actually a product change. It is not enough to call it "high-end" simply because the price has increased or the packaging has become more exquisite.

There are two problems left over from history on the road of product innovation of Huaxizi. One is the lack of R&D investment. In order to achieve overtaking in corners, most domestic beauty brands choose the way of strong marketing investment to earn traffic, and quickly get out of the circle by creating online celebrity single products. Faced with numerous competitive pressures, Huaxizi naturally does not want to give up marketing traffic, which leads to the word-of-mouth waterloo for Huaxizi, who pays more attention to marketing than R&D; On the other hand, Huaxizi doesn’t have its own factory, so it is highly dependent on the foundry, and the foundry of Huaxizi also frequently appears "rollover" behavior. According to the information of Tianyanchi, the enterprises that Huaxizi has cooperated with for many times have been asked by the Market Supervision Administration twice to "take measures for rectification".

Although it is far from the "high-end" at present, it is actually a better way to enter the high-end market, because after several rounds of price increases, Huaxizi has already stepped out of the circle of parity, and the customer unit price of Huaxizi has risen to 150 yuan. In contrast, the customer unit price of Perfect Diary is distributed in the range of 50~70 yuan, which is really in the echelon of parity.

In China’s beauty market, there is still much room for the development of high-end products. For a long time, China’s beauty market has been occupied by foreign products, and high-end products are almost monopolized by international makeup brands such as Europe, America, Japan and South Korea, making it difficult for domestic beauty products to survive. Moreover, compared with international brands such as Dior, Saint Laurent and Lancome, which have been established for at least ten years, the domestic cosmetics brands with a short history, such as Hua Xizi, have lower strength in word of mouth, trust and cultural accumulation. However, the rise of the national tide has made users see that domestic products are not only a "substitute" for big brands, but even more cost-effective solutions are exported through product innovation, and product innovations are also emerging one after another. According to public data, Hua Xi Bio and Nature Hall.

Hua Xizi is actually changing. In early January, 2022, Hua Xizi announced that Villi Liang, the former chief technology officer of Huaxi Bio, would join his R&D team, and declared that he would invest 1 billion yuan in product innovation and basic research in the next five years. Prior to this, Hua Xizi built a number of research centers, including the Oriental Aesthetics and Space Innovation Center, with a total area of 6,000 square meters. This is an important measure for Hua Xizi to speed up the development of his own products.

Is Hua Xizi’s "Oriental Aesthetics" Reliable? The answer may still be related to whether its products can withstand the market test. Now, it seems that the direction of the national wind is actually correct, and it is also a "good agent" that is more suitable for Hua Xizi to form a unique recognition among many domestic brands of cosmetics. The reason for the gift box incident is actually that the behavior mode of emphasizing marketing and neglecting research and development makes Hua Xizi go more and more on the marketing road, resulting in the "beauty of the East" leaving only "the East" and the lack of aesthetic feeling.

But in the future, with the blessing of product innovation and the original user base, marketing ability and marketing resources of Huaxizi, I believe that it will eventually be able to embark on a road of its own high-end brand. At that time, the beauty of the East will really shine.END

References:

Zhao Wanli’s Research on Beauty Brand Innovation from the Perspective of National Tide Culture

Yang Xiaoman and Song Shaoyi, A Study on the Marketing Strategy of Guochao Beauty Brand under the Consumption Characteristics of Z Era —— Taking Hua Xizi as an Example.

Research on Communication Power "Research on Word-of-mouth Marketing Strategy of Huaxizi Based on 5T Theory"

Research on the Transformation and Development of Domestic Beauty Products —— Taking Hua Xizi as an Example by Business School of Chengdu University.

Box lunch finance "Hua Xizi’s Li Jiaqi Dependence"

Blue Media Exchange "How many more" Flower Xizi "can Li Jiaqi recreate"

Economic Observer Hua Xizi: "Abandoning" Li Jiaqi

Caught in a marketing siege, how long can Huaxizi bear the title of "Light of Domestic Products"? 》

See the column "Can the upstart makeup flower Xizi tear off the" online celebrity "label? 》

Xiangshan Technology "Fairy Brand Flower West Son, where is the future imagination?" 》

Special feature of 1905 film network "What is the biggest secret of China’s atomic bomb? It can be made. " "I believe that the plane is the same, whether it is an engine or a stealth fighter, it can be made."

In the movie, these words played by Zhang Ting and Lei Yu explain the firm and victorious belief that generations of China aviation people have made great powers.

The film portrays the heroic image of a new generation of China Air Force test pilots through starring YiBo, Hu Jun, etc. At the same time, it reveals the history behind the difficult birth of new fighters in China.

After the release of "King of the Sky", a bright report card was handed over: after four days of release, the cumulative box office broke 300 million, ranking as the May 1st box office champion so far. Taobao Film 9.7, Cat’s Eye 9.6, Douban 7.0, ranked first in May 1st, with popcorn index of 97% and IMDb8 score of 8, which was well received by the whole network at home and abroad.

Then, as a film, How was King of the Sky made? In 1905, the film network interviewed the director of "King of the Sky" and listened to him decrypt the behind-the-scenes story of the film from many angles.

It is both a film project and a scientific research project.

Director Liu Xiaoshi is an aviation fan. When he was studying in the director department of Beijing Film Academy, he made a documentary for the aviation industry group. After graduation, he also worked in the aviation industry for 15 years.

Liu Xiaoshi knows the story of the test pilot group and the flight test process very well. He participated in the riveting ceremony of the first screw produced by the J -20 and contacted the J -20 fighter many times. Li Gang, the chief test pilot of the J -20, is also his good friend.

"I am very touched by what happened to the test pilot. It is necessary to make a film about the test pilot to let more people know about such a group and how difficult it is to know the progress of aviation equipment in our country."

The first script of "The King of the Sky" was released in 2019. He and the screenwriter Guiguan spent more than three years repeatedly revising and polishing. "There are about forty scripts with numbers, and there are about one or two hundred scripts without numbers."

Liu Xiaoshi said that this script has a lot of rigorous aviation science logic, which needs to be repeatedly demonstrated with relevant engineers and scientists, and it is a very big challenge and topic to write the story satisfactorily and write the characters with flesh and blood.

Because of his work, he has photographed many planes and accumulated some failed experiences and lessons. Liu Xiaoshi didn’t want to make mistakes again in this film, so he spent nearly a year exploring the previous technology. "I very much hope that there will be a leap and improvement in shooting technology. For example, we used virtual shooting to control the linkage between the background image and the mechanical device by programming. "

The crew also prepared for the production one and a half years in advance. Every aerial scene will not only prepare one shooting plan. "It’s really like scientific research, there are several ABC plans. We did tests in Beijing, Fuzhou, Xiangshan and other places, and the plan was very rich and sufficient. "

In the view of director Liu Xiaoshi, the production of "The King of the Sky" is "both a film project and a scientific research project."

Aviation equipment is growing, and so are people.

"The King of the Sky" is not only a passionate Chinese air force blockbuster, but also a film about growth. "The film is about the growth of a generation of young test pilots and the progress of a generation of equipment. Equipment is growing and people are growing. "

Liu Xiaoshi said that Zhang Ting, the captain played by Hu Jun, was an example for the test flight team. "Zhang Ting voluntarily gave the chief to others, which was very touching to both Lei Yu and Deng Fang. What everyone thinks is very important, Zhang Ting doesn’t care at all, because he wants to inspire everyone to compete and improve their ability. Only through these experiences can Lei Yu and others really grow up.

Including the sacrifice of Zhang Dadui. He told Lei Yu who would jump first, but Zhang lied to him. Because someone must fly the plane out of the city and land in no man’s land, in order to skydive completely. This is all an inner influence on a person, which enables Lei Yu to grow up. "

In the film, Lei Yu and Deng Fang changed from competitors who looked down on each other to working together to accomplish difficult tasks, and became real comrades-in-arms. The formation of this friendship is also very moving in Liu Xiaoshi’s view.

Repeated trials and transformations have given Lei Yu a complete growth line. Among them, when he made a mistake, he was sent to pack an umbrella, which is rare in similar air force movies, which stems from the advice provided by the air force leaders. Before shooting, Liu Xiaoshi led the creative team to visit the umbrella bag room, and saw that the umbrella bag man, like a skilled craftsman, carefully filled a messy rope into the umbrella tube, which inspired him.

"Once there is a small negligence in the process of umbrella packing, it may have a particularly great impact on the landing and safety of the aircraft. At that time, we felt that this was very important for the growth of the characters, so we wrote it in the story. " The process of learning to wrap an umbrella made Lei Yu understand his mission better, and inspired him to design ideas to alleviate the problem of airplane spin.

As a new actor, Lei Yu played by YiBo brought many surprises to Director Liu Xiaoshi. "Now Lei Yu, YiBo is very suitable, he should play such a person. Yibo is a very polite and thoughtful person, and so is Lei Yu. "

"He is a very sensitive actor and enters the situation quickly. When he played many plays for the first time, I was quite surprised. Many details were entirely his own play. " For example, in the first scene of filming, Lei Yu fell into the sheepfold. "After he pulled out from under the umbrella, he looked at the sky. At this look, I think he can do it, completely putting himself into the situation after a pilot fell into the sheepfold. "

"In the more than 100 days we filmed, he was never late once, and he was very dedicated every day. No matter whether it was dangerous or suffering, he did not give a discount to carry out it." Liu Xiaoshi recalled.

Write stories about China people and don’t blindly imitate western movies.

The test pilot is a dancer on the tip of a knife and a warrior in the blue sky. Only when they break through the limits again and again can they try out the limits of new planes and explore new fighters that roar in the sky.

"The biggest difference between a test pilot and a front-line combatant is that one has to beat himself and the other has to beat his opponent. The target of frontline combatants is the enemy. The test pilots should improve their flying ability and aviation theory knowledge, and overcome their fears. " There is a line in the movie that says, "The new generation of test pilots are designers and engineers who can fly." They should know not only actual combat and theory, but also design technology.

Liu Xiaoshi believes that only by approaching the current test pilot group, feeling, seeing and observing can we write their stories well. "We must write China people’s own stories, and we can’t blindly imitate western movies. They ride motorcycles, and we also ride motorcycles in movies, but China soldiers don’t; They go to the bar, so do we. Our troops are not like this. "

The film has a hopeful ending. Instead of captain Zhang Ting, Lei Yu flew by on the football field, realizing Zhang Ting’s son’s wish. The growth story of Lei Yu and the younger generation and their dream of flying are still going on. Liu Xiaoshi revealed that "The King of the Sky" does not rule out the plan of making a sequel.

He hopes that the audience can understand the spiritual outlook of contemporary young test pilots and soldiers through King of the Sky, so that more and more people can understand the difficulties behind the development of China’s aviation industry and inspire the next generation to embrace the beautiful ideal of loving flying.

In the past year, many netizens have been there.The style of tucao costume idol drama is getting more and more lame.It is far less beautiful than the costume dramas of the 1980s and 1990s. No, at the beginning of the new year, when I saw this topic so interesting, bloggers immediately stood up.Taking stock of the main styles of men and women in costume idol dramas to be broadcast.

Among them, among the heroines, at first glance,In The Queen Liu Heipang, played by Yoko Spicy Eye, Liu Tianfeng is the most eye-catching.. The drama mainly tells the story that Liu Jinfeng, a flower from Xianpa village, made a mockery everywhere after she married into the palace, which led to the emperor being laughed at everywhere, but in the end, the "misfit" couple experienced another disaster and started a happy story.

With such a detached plot, the shape is naturally unique, coupled with the rich and clever expression of Yoko Spicy, so that everyone can lock it in an instant.

Yoko spicy eye can be seen by everyone at a glance, not simply because her style is really excellent and unique.It’s that Yoko Ayako is a different existence from other actresses, and now she is favored by people with great potential.

So, the reason why she has the potential to explode,To deus ex, mainly rely on the following aspects.

First, "non-mainstream" appearance, refusing appearance anxiety

In theory,Yoko Lamu has no facial features that strictly belong to the traditional aesthetic standards of China people.. The round fleshy face is covered with dense freckles, small eyes, and a nose that is not quite upturned. The only thing that stands out is that the mouth is still a small cherry mouth. What do all the female stars look like? Just follow the facial features of Yoko spicy eyes in the opposite direction, that is, beauty.

With the popularization of mass media, girls are looking at glamorous female stars and demanding more and more about their appearance.Appearance anxiety is getting worse.It also caused the mobile phone P-picture and the medical beauty industry to triumph all the way.

With such five senses, how does Yoko Spicy Eye treat the camera in this era? Self-confident, generous, overflowing, no stage fright.

When she was in high school, she wrote a shocking sentence in her diary: "I am not beautiful, but this one is out of print." A woman who has a clear understanding of herself before she is a minor,Refusing to "go along with the current aesthetics", Yoko Spicy has kept this mentality and played it to the present..

Second, the acting skills have emerged, and there is no sense of disobedience in Gu Li

In the hit variety "Actor in Place 2", Yoko Spicy challenged to play the role of Gu Li. Who is Gu Li’s character? Everyone is too familiar. Flashy and mean, delicate and fragile, the drama is gorgeous. After the film and television, the role of Gu Li was well recreated by Jing M.Guo, the original author of the novel, and the accent blessing of Guo Caijie Taiwanese accent. I’m afraid looking at the entertainment circle,I can’t find another actress who can challenge Gu Li.

However, Yoko spicy eyes became!

A female artist who at first glance had nothing to do with Gu Li’s setting, used a short scene to put the audience into the plot 360 degrees, and soon went out on the hot search.

Netizens are amazed and think that this actress is too powerful. In fact, as early as the first scene of Yoko Ramo’s performance "The Thief Family",Er Dongsheng directly decided that she would win the best actress in the future.With such high recognition from the great director, her future is very promising.

Third, contact Bole and connect with Shen Teng.

In the Golden Rooster Awards just past,Shen Teng and three other main pillars in Mahua FunAge recommended Yoko Ramo in the "Best Selection Plan for Young Actors in the Stars and Seas in 2021".

Yoko Ramo became attached to them in Me and My Father. In the unit directed by Shen Teng, Yoko Ramo played the role of the head teacher, which was not much, but in this regard, she hooked up with a group of actors in Mahua FunAge. Only when Yoko Mori has done well himself can he be appreciated by the Mahua FunAge team.

Fourth, diversification of resources, Disney dubbing+reality show

About to meet the audienceThe Chinese version of Disney’s latest masterpiece "Magic Room Full" will be dubbed by Yoko Ramo.. In the past, in order to match their princess phenomenon, Disney’s female stars were all popular young Hua Dan, but now they have also thrown olive branches on Yoko Spicy.

Not only that, in the reality show with the lowest threshold, Yoko Spicy appears frequently. I can’t forget the farm, Fifty Kilometers of Peach Blossom House and so on.

For many years, women who are ugly and confident at the same time can only be defined as comedians in the entertainment circle. I hope that Yoko Mori can get a completely different new image as an actress by virtue of her excellent acting skills.

Today’s People’s Daily published an article "Adding More Seaside Space for Citizens and Tourists" in the column "Practice of Ludao Butterfly in Xiamen", paying attention to the continuous beach protection and restoration in Xiamen, Fujian.

The article said that in the 1980s, due to natural and human factors, the beaches in Xiamen were damaged to varying degrees. The common method of early coastal protection is to build hard revetment with riprap and reinforced concrete. Xiamen, on the other hand, follows the principle of "beach is suitable" to restore beaches, enhance coastal protection capacity and carry out systematic protection and restoration of beaches.

Since 2007, Xiamen has successively completed the protection and restoration of many beaches such as Guanyin Mountain, Convention and Exhibition Center and Gulangyu Island, with a cumulative restoration area of 1.65 million square meters. In the process of protection and restoration, Xiamen insists on leaving the most beautiful coastline to the people. The total beach area of the city is 2.4 million square meters, which adds more sea-friendly space for citizens and tourists. Xiamen organically combines sports, culture, tourism and leisure facilities, and organizes beach football matches, beach culture festivals and other activities. The once dirty beach has become a scenic beach and an activity area for cultural and sports events.

In recent years, Xiamen has continuously strengthened cooperation with scientific research institutes in beach protection and restoration, increased investment in scientific research and development, and carried out basic and applied scientific research on beach conservation. Together with the Third Institute of Oceanography of the Ministry of Natural Resources and other units, a number of industry standards have been compiled and approved by the Ministry of Natural Resources, which has become an important support for scientific and standardized beach maintenance and restoration projects. Related technologies have been gradually extended to Guangdong, Hainan and other provinces, and have also been applied to coastal protection projects in countries such as Thailand and Sri Lanka where the Belt and Road Initiative is jointly built.

(Observer News) According to Kyodo News, the world baseball classic (WBC) final was held in Miami, Florida, USA on the 21st local time. Japan defeated the last champion, the United States, 3-2 to win the championship for the third time. The last time Japan won the championship was the second WBC in 2009.

Japan won the championship. Figure from Kyodo News

Recently, Yan Ning, a famous structural biologist, announced that he would resign from Princeton University and set up the Academy of Medical Sciences in Shenzhen. In response to the latest research that she will focus on when she returns to China, she said that the discovery of structural biology is of great significance to the pharmaceutical industry, including the research on the interaction between drugs and hormones, which has more implications for drug development and disease treatment.

Yan Ning said, for example, that through the method of structural biology, scientists saw for the first time that two commonly used drugs used protein as a "scaffold", which directly "side by side" affected the normal function of protein.

Technological change promotes the development of structural biology.

Protein, as the scaffold and main substance of human tissues and organs, plays an important role in human life activities. In the cell, a large number of protein elements form the molecular machines, which performs important molecular processes in the cell through the interaction of protein, including the cell’s response to the external environment and the internal environment, and also forms a signal transduction network system with the interaction of protein as a link.

Structure By studying the three-dimensional structure, dynamic process and biological function of biological macromolecules, biology can provide more details of protein interaction and real-time dynamic process, thus helping scientists to understand molecular mechanism and explore the pathogenesis of diseases related to macromolecular dysfunction.

The development of biology not only contributes to the discovery of drugs, but also affects the research fields of life sciences including biochemistry, cell biology, genetic development, neurobiology, microbiology and pathopharmacology.

The development of science and technology has been promoting the progress of structural biology. In 2017, the Nobel Prize in Chemistry was awarded to cryoelectron microscopy, which can greatly improve the efficiency of analyzing the atomic resolution three-dimensional structure of large protein complexes; Moreover, researchers can freeze biomolecules in motion and visualize their motion process.

This breakthrough has brought a perfect storm to the field of structural biology. In recent years, important breakthroughs have been made in the field of life sciences. The work of China scientists such as Cheng Yifan, Shi Yigong, Yang Maojun and Liu Zhengfeng has also benefited from this technology. They have analyzed the important complex structure of atomic resolution. In addition, the enzyme that produces the protein that leads to Alzheimer’s syndrome was analyzed by cryomicroscope.

In August, 2015, Shi Yigong’s research team published an article in Nature, reporting the three-dimensional electron microscope structure of human γ -secretase with a resolution of 3.4 angstrom, and studying the function of the pathogenic mutant of γ -secretase based on the structure analysis, which provided an important foundation for understanding the working mechanism of γ -secretase and the pathogenesis of Alzheimer’s disease.

In February, 2020, after the outbreak of COVID-19, the research team of West Lake University successfully analyzed the full-length structure of novel coronavirus receptor ACE2 for the first time by using cryo-electron microscopy, which helped the research and development of drugs in COVID-19.

What does AI predict protein folding change?

With the help of artificial intelligence technology, DeepMind, a subsidiary of Google, recently announced 220 million kinds of protein structures predicted by AlphaFold software, which shocked the field of structural biology, because it indicates that artificial intelligence enterprises have begun to "truly hand over the power of Al to scientists all over the world".

Scientists compare the significance of this disruptive breakthrough with the human genome project. In the 1990s, when the Human Genome Project began to take shape, scientists realized that it was not enough to master the base arrangement of genes, but also to know the protein, the product of genes.

Shi Yigong, academician of China Academy of Sciences, structural biologist and president of West Lake University, commented on AlphaFold’s work: "Its accurate prediction of protein structure is the greatest contribution of artificial intelligence to the scientific field, and it is also one of the most important scientific breakthroughs made by mankind in the 21st century."

Shi Yigong once told China Business News: "AlphaFold represents the world’s leading artificial intelligence protein organization prediction system." At the same time, he said, China’s high-tech enterprises are catching up, expecting to bring surprises to the world in the near future.

He also said that the improvement of the accuracy of protein structure prediction will greatly benefit the pharmaceutical industry. "Artificial intelligence prediction of protein structure provides an important foundation for drug design and optimization. The structure of drug target proteins combined with all small molecule drugs can almost be wiped out by AlphaFold. " Shi Yigong said.

In the opinion of some scientists, although AlphaFold’s work is shocking, the accuracy of drug research and development prediction is not enough. Professor Liu Zhijie, executive director of iHuman Institute, Shanghai University of Science and Technology, told the First Financial Reporter: "It has been a long time to predict the protein structure. Now the accuracy of the prediction is definitely getting higher and higher, but it still hasn’t reached the precision of crystal structure."

Liu Zhijie First Financial News told the reporter that the crystal structure is the most accurate, and now artificial intelligence can predict the protein folding with the accuracy of electron microscope and nuclear magnetic resonance. In addition, because there are thousands of structures in protein, the difficulty of analysis is different. "If some protein sequences are similar to the known structure of artificial intelligence, it is easier to predict." Liu Zhijie said.

However, he still believes that with the continuous improvement of the prediction accuracy of protein folding, it will play a more important role in the field of life sciences in the future. "If the current prediction can reach the accuracy of electron microscope, some drugs can already be designed. Drug design is the biggest application field of artificial intelligence protein folding prediction." Said to Liu Zhijie First Financial Reporter.

Others think that with the development of artificial intelligence, there may not be so many structural biologists in the future. "Many researchers who do structural biology are actually more like technical service personnel. The more people there are, the more structures that can be analyzed. Therefore, in essence, a large part of their work depends on manpower. Now with AI, it is true that a large number of people who do structural biology have changed careers." A virus researcher told the First Financial News reporter.

However, for top structural biologists such as Shi Yigong, technology is only a powerful support for the "top brain", which can help them realize more ideas. "Every conscientious biologist should know how to make good use of the structural prediction of artificial intelligence." Shi Yigong said.

Professor Michael Levitt, winner of the Nobel Prize in Chemistry in 2013, told China Business News: "I think many structural biologists are not only doing structural research, but also doing a lot of work on protein function and drug research and development, just like Professor Yan Ning. Artificial intelligence only liberates a part of traditional manpower, but the progress of science still needs to rely on the smartest human brain. I’m afraid that artificial intelligence alone will not work. "

In recent years, a number of AI pharmaceutical companies have also been born in China. In this regard, Ewing Nan, academician of Chinese Academy of Sciences and president of Beijing Institute of Scientific Intelligence, pointed out to the First Financial Reporter: "The emergence of AI for Science research paradigm is an important historical opportunity for scientific and technological innovation, which not only expands the capability boundary of data-driven and physical model-driven models, but also is expected to promote the organic combination of the two, provide theoretical basis for further solving practical problems, and greatly narrow the distance between scientific research and practical application."

#270,000 elderly golden cases open##

The truth of this fact is that from 2009 to 2015, the old lady of Shanghai, Qian Mou, would abandon the husband who lost his ability to take care of his self -care in the hospital after paying some medical expenses during the hospitalization treatment, until the husband died alone. After the death of her husband, Qian still refused to go through the relevant procedures, and at the same time, he took the husband’s pension and accounted for himself.

On June 9, 2021, a case of fraud and abandonment of Qian, a public prosecution of the People’s Procuratorate of Minhang District, Shanghai, was held in the Minhang District People’s Court.

The truth of the case is very clear.

Some people think that pensions are in the country, and the national Tang monk meat, all Chinese citizens can eat, all of which are desirable. Therefore, it is not believed that the old lady of Shanghai Qian Mou is a criminal act. This view is particularly popular in the small and fresh meat little beauties. Because the little fresh meat and the little beauty thinks that farmers are reasonable to eat white food, everyone can not pay a penny social security, and they can be sits to share the social security provers for decades.

However, the understanding of farmers is extreme errors.

In the basic composition of pensions, all pensions of social insurance forms should belong to the private property of citizens who pay social security, and they are not owned by the whole society. In the basic pension of the national welfare form, [also known as the pension subsidy], that is, the country’s money from the city taxpayer to the farmer, the other social benefits that belong to the country to the farmers to the elderly.

Compared with the former, although it is also called pension, it is actually very different in nature. That is to say, the essence of social maintenance money is the private property of citizens who pay social security. They use their labor income to take out a part of their salary every month to invest in their future pensions, like bank savings. But more advanced than banks, these social property from citizens is managed by the state and has absolute security and insurance stability. The basic pension [also known as the pension subsidy for white hair to the farmers], the source of funds is not the citizen of the social security, but from the city’s hundreds of millions of taxpayers. Do not bear the tax responsibilities and obligations that every citizen should have, and the one billion farmers have no longer contributed a penny to the national fiscal tax for seventeen years. Therefore, these money -sweats from urban taxpayers have been distributed to farmers through the hands of the country. The money does not have the nature of private property, but has a social welfare nature.

Understanding the above principles, I understand that the old lady of Shanghai, Qian Mou, led her died of more than 270,000 yuan. The violent object was the private property of all social security citizens.

Similarly, those who do not pay a penny for social security, and those who have to pay the social security persons for decades of social security people are divided by farmers, which are those who eat white food selfish little fresh meat and little beauty. In fact Criminal behavior, they are public robbery, because their violations are the private property of the whole society who has paid social security for decades. But it is terrible that some people have committed guilty and do not know sin. Zhen Zhen has words that he is the savior of the peasant. He has called for robbery and plundering under the banner of speaking for farmers. As criminals, they have gone far enough on the road of illegal.

These pension articles videos are full of headlines. This fully shows that a large number of cyber criminals are active on the media network. They attempted to learn ancient bandits and live on the wealth of others by robbing others.

The opening of the old lady in Shanghai should let the small and fresh meat and little beauties who advocated robbery to calm the rational and rational girls. Please do not go further and further on the road of crime.