Zhangye, Gansu: More than 30 artificial lakes have "grown" in arid areas

  On December 1, on the occasion of the 20th anniversary of Tencent News, the 2023 Tencent ConTech Conference was held. The theme of this year’s conference is "The Year of Sometimes". The conference invited well-known economists, entrepreneurs, investors, scholars, writers, emerging young directors and Tencent news content creators to engage in speculation and dialogue on topics such as "growth sources, intelligent emergence, change symbiosis, and polyphony" based on future trends and changes.

  At the opening of the conference, He Yijin, the head of Tencent News, delivered a keynote speech of "Sometimes the year, walking with the times", proposing that it will continue to provide users with a "new thinking, new knowledge, new joy, new flame" information content consumption experience through content, product and technological innovation. First, Tencent News has set aside 95% of the stock content compared to before. At the same time, on the basis of the end of last year, Tencent News added 17% of the content, including content creation by experts and practitioners in various industries; secondly, in terms of product experience, Tencent News is committed to continuously improving the efficiency of user consumption through morning and evening newspapers, night reading, second understanding, 724 express, and selected channels, so that users can obtain the required content in a timely and effective manner.

  In the high-end dialogue session of the conference, renowned economists, entrepreneurs, investors, scholars, writers, and emerging young directors held dialogues on four topics: growth drivers, intelligent emergence, change symbiosis, and polyphonic life, to jointly explore current and future issues and look forward to the next 20 years.

  Professor Huang Yiping, Vice President of the National Development Research Institute of Peking University, Liu Yonghao, Member of the 14th National Committee of the Chinese People’s Political Consultative Conference and Chairperson of New Hope Group, and Su Kai, Partner of Sequoia China, used the theme of "Growth Source" to imagine how to find new engines and breaking points through innovation in the new cycle.

  When facing environmental changes and cyclical lows, how should companies break through? Huang Yiping believes that the most important issue now is that the economic environment has changed, requiring a new economic growth model. This model must mean that we must pay more attention to the domestic market, place more emphasis on innovation, and place more emphasis on the role of technology in driving the economy.

  2023 is a year redefined by artificial intelligence. GPT has changed and evolved several times, and the wave brought by the big model has swept the world. AGI is considered the "fourth industrial revolution". Sun Tianshu, a professor at Cheung Kong Graduate School of Business and director of the digital transformation center, and Wang Xiaochuan, founder of Baichuan Intelligent, a leader in the artificial intelligence industry, and Qiu Xipeng, a professor at the School of Computer Science of Fudan University and the head of the Moss system, discussed how AI will reshape thousands of industries in the next 20 years.

  At the conference, Tencent News also released a blueprint for high-quality content in 2024.

Which new car preview in the second quarter is the most exciting for you?

There is a saying that there is gold, silver and four in job hunting, and March and April is the best time to launch new cars in the automobile circle. The new car market in the past March can be described as overwhelming, and the heat in April and even the second quarter is still unabated, especially with the blessing of the auto show. Having said that, what new cars will be on the scene in the second quarter? Let’s get to know each other in advance.

car make and model time Rubik’s Cube It is expected to be listed in April. Brand new range rover Listed in April e:NS1 Listed in April New Kodiak Listed on April 8 Fit unlimited MUGEN edition Listed on April 30th. New mondeo Auto show listing New Weimar E.5 Auto show listing Lantu dreamer Pre-sale on April 7 Genie #1 Debut on April 7 The first MPV Officially unveiled in April Next Generation BMW 7 Series /i7 World premiere in April Ideality L9 Auto show debut Nezha s Auto show pre-sale Tucki G9 Auto show pre-sale Tiggo 8 PRO It is expected to be listed in May. brand-new Listed in the second quarter OMODA 5 It is expected to be listed in the second quarter.

Beiqi Rubik’s Cube is expected to be listed in April. The pre-sale price range is 110,000-150,000 yuan.

Rubik’s Cube is the first fuel vehicle equipped with Huawei’s HarmonyOS vehicle system. At the same time, it has applied a brand-new design language and a brand-new power platform, and achieved all-round product image advancement in terms of intelligence, aesthetics and power consumption.

As the first smart car with full scene definition, the new car adopts a subversive design language, adding hidden door handles, electronic rearview mirrors and other elements, which is more like a new energy vehicle visually. In addition, the body size of the Rubik’s Cube is 4620/1886/1680mm and the wheelbase is 2735mm.

The Rubik’s Cube is equipped with Huawei’s smart cockpit, which brings users a variety of smart cockpit experiences based on the HarmonyOS OS ecosystem. It is equipped with a car-level Kirin 990A chip and supports 5G network connection. It can share the ecology with eight smart terminals such as Huawei’s mobile phones, watches and glasses, and cooperate with smart home devices.

In terms of power, the Rubik’s Cube is equipped with the top 10 engines of Magic Core 1.5T "China Heart" in 2021, using VGT technology, and the thermal efficiency is as high as 39.2%. The maximum power of this engine is 138 kW, and the peak torque is 305 Nm. According to official data, its 0-100km/h acceleration time takes only 7.9 seconds.

Pre-sale price of the new Range Rover in April: RMB 2,098,800-RMB 2,518,800.

After many years, it was replaced again. The new Range Rover was built based on MLA-FLEX architecture, and 80% of the body was made of aluminum alloy, which improved the rigidity of the body by 50% while reducing the weight.

In terms of design, the brand-new Range Rover looks more concise and atmospheric under the sleek and tough shape, especially the combination of the brand-new inverted trapezoidal honeycomb grille and intelligent digital LED headlights, and the gas field is in place.

Hidden door handles and electric pedals are added to the side of the new Range Rover to improve the convenience of getting on and off. This time, the new Range Rover offers two models, the standard axis version and the long axis version, in which the long axis version has a length of more than 5.2 meters and a wheelbase of 3,197 mm.

The rear of the new car still maintains simple design elements, and the flat body profile with hidden D-pillar design looks unique. It is worth noting that the Range Rover taillights are vertically designed, and the turn signals are hidden in the black trim panel.

In terms of interiors, the new Range Rover mostly uses horizontal and vertical lines to cut, which echoes the appearance. The 13.1-inch touch screen in the center of the new car adopts a borderless curved surface suspension design, and the InControl OS 2.0 infotainment system installed in the car can be well matched with the 13.7-inch interactive dashboard, and it has more than 50 electronic control units to support software online upgrade technology (SOTA).

In terms of power, the new Range Rover provides 3.0T and 4.4T V8 power, of which the maximum output power of the 3.0T engine is 294kW and the peak torque is 550 Nm. The 4.4-liter P530 twin-turbo V8 engine has a maximum power of 340kW and a peak torque of 750 Nm. The transmission system is matched with 8AT automatic gearbox and equipped with full-time four-wheel drive system.

E: NS1 was listed in April, with a pre-sale of 180,000-210,000 yuan.

E:NS1 positioning small pure electric SUV is the first model launched by brand-new pure electric brand E: N. The pre-sale price of E-version is 180,000-190,000 yuan (cruising range of CLTC is 420km) and the pre-sale price of E-version is 200,000-210,000 yuan (cruising range of CLTC is 510km).

In design, the new headlight group is slender and blackened, which looks very radical as a whole. In addition, the new logo also has a "Heart beat interactive light language" full of life. It is worth mentioning that the handle of the front door of e:NS1 does not use the concealed design popular in electric vehicles, but the position of the handle of the rear door of this car adopts the same C-pillar position.

In terms of body size, the length, width and height of e:NS1 are 4390*1790*1560mm respectively, and the wheelbase is 2610mm. The rear of the new car has a strong sense of hierarchy, and the through taillight design enhances the sense of movement. In addition, the car also has a black tail with a different color from the body.

In terms of interior, e:NS1 is relatively simple as it lacks many physical buttons. The three-spoke steering wheel adopts a brand-new style, and the multi-function buttons on the left side are multimedia control areas and the cruise control areas on the right side. In addition, there is a 10.25-inch full LCD instrument panel in front of the e:NS1. The car’s vertical 15.2-inch central control panel supports mainstream functions such as online navigation, online music and online radio.

In terms of power, e:NS1 will provide two front motors with maximum power of 134kW or 150kW+ternary lithium battery pack with capacity of 68.8kWh. In terms of endurance, the cruising range of E-version and E-version CLTC is 510km and 420km respectively.

The price range of the new Kodiak listed on April 8 is 186,900 yuan-243,900 yuan.

As a redesigned model, the new Kodiak has launched six models, including two 5-seat models, two 7-seat models and two sports GT models, with the price range of 186,900 yuan-243,900 yuan.

The new Kodiak is optimized for the front face details, and the iconic LED headlights adopt a sharper shape; And the front enclosure of the car has been redesigned, which further reduces the area and makes the whole front face more rounded. The sports GT model adopts a coupe shape with a 20-inch rim, a black suspended roof, an obsidian black air intake grille and a sports V-shaped diffuser. In terms of the rear end, the new car still uses the family’s iconic C-shaped taillights and the internal shape has been adjusted. In addition, the silver exhaust at the bottom of the car is decorative trim, which makes the tail look more sporty.

The new Kodiak uses a three-spoke flat-bottomed steering wheel, a floating rotary button, a floating paddle air conditioner adjustment button, and a KODIAQ exclusive plate. The central control 12-inch large-size floating screen is equipped with a new smart car coupling system of MOS 3.X In addition, the shape of the new Kodiak 10.25-inch full LCD digital instrument has also been upgraded, and the whole interior looks very scientific and technological.

In terms of power, the new Kodiak is equipped with the third-generation EA888 series 2.0T turbocharged engine; The flagship model is equipped with a 2.0T performance turbocharged engine with an ejection start mode and an intelligent four-wheel drive system, with an acceleration of 7.5 seconds at 0-100 km/h.

Fit Unlimited MUGEN Edition went on sale on April 30th.

The new car is based on Fit GR9, and designed by the royal refitting manufacturer MUGEN. The Fit Unlimited MUGEN version is equipped with exclusive sports components, and the overall shape is more dynamic. In the front face part, chrome trim strips are added to the center of the honeycomb blackened air intake grille of the new car for embellishment, and the front enclosure component with exaggerated bottom shape is full of sports atmosphere. In addition, the car also added the "Infinite MUGEN" badge at the grille to show its identity.

The side of the new car is designed with multiple waistlines, and the car is also equipped with a bright black roof and an exterior rearview mirror to further enhance its fashion sense. It is worth mentioning that the Fit Unlimited MUGEN version is equipped with exclusive side skirt components and multi-spoke blackened wheels to further enhance its sense of movement.

In the rear part, the Fit Unlimited MUGEN version is equipped with a bright black roof spoiler and shark fin antenna, with sharp taillights on both sides, which is highly recognizable. At the same time, the car also has an exclusive rear diffuser component, which makes the visual experience more fierce. In the power part, the Fit Unlimited MUGEN version is expected to continue to be equipped with a 1.5-liter engine and match the CVT gearbox.

brand-newMondeo is expected to be listed at the auto show with a pre-sale price range of 159,800-219,800 yuan.

Previously, the brand-new has started pre-sale, and a total of four models have been launched, with a pre-sale price range of 159,800-219,800 yuan.

In terms of appearance, the new Mondeo adopts the latest family-style design language, and the overall shape is more dynamic. In the front part, the new car is equipped with a large-size blackened air intake grille, and the interior is a scale design, which is highly recognizable by combining the split headlights with sharp shapes on both sides. In addition, the car will be equipped with a brand-new front enclosure component to further enhance its sense of movement.

The new Mondeo has a smooth side shape and a multi-waistline design, and its roof line extends all the way to the tail, which is very dynamic as a whole. In addition, the car is equipped with a hidden door handle, combined with chrome trim at the window frame and side lip to further enhance its fashion sense. At the same time, the new Mondeo will also provide a variety of large-size rims for customers to choose from.

The new Mondeo tail shape is full, and it uses a through blackened LED taillight group, which is highly recognizable after lighting. In addition, the car is equipped with a bright black roof shark fin antenna and a small duck tail spoiler, which is full of sports. It is worth mentioning that the car is equipped with a brand-new rear enclosure component and decorated with chrome trim.

In the interior part, the new Mondeo is equipped with a giant 27-inch horizontal LCD screen with a length of 1.1 meters, which can enhance the sense of technology in the car and provide a richer functional experience. In addition, the interior of the car adopts black/white double color matching, and is covered with a large number of high-end soft-touch materials, which is very textured as a whole. In addition, the new Mondeo is equipped with a 10-speaker B&O stereo.

In terms of power, the new Mondeo is equipped with a 2.0T EcoBoost four-cylinder turbocharged engine with a maximum output of 175 kW and a peak torque of 376 Nm. The transmission part is matched with an 8-speed automatic manual transmission.

Brand-new Weimar E.5 Auto Show goes on sale.

E.5 is Weimar’s first car product, which adopts the family flying wing front face, high-gloss piano paint closed grille and bright silver electroplating interactive luminous LOGO, highlighting the sense of science and technology. The fog light area of the car refers to the shape of the two wings of the fighter, which optimizes aerodynamics and makes it more impactful. In addition, Weimar E.5 geometric far and near lens headlights (with automatic opening and closing function), daytime running lights and turn signals are integrated, showing simplicity.

The side of the new car is designed with a sliding back, and the roof is decorated with black trim to create a floating effect. In addition, the car also uses 18-inch 5-spoke two-color wheels, which use dark and light to highlight the layering. In the tail, the butterfly-wing blackened taillights echo the headlights and are recognizable.

In terms of interior, Weimar E.5 adopts the style of horizontally embracing the cockpit, and the 12.3-inch large screen supports rich information such as intelligent navigation, X-CALL rescue, multimedia APP, intelligent voice, and remote interaction of mobile APP. In terms of seats, the leather+fabric materials used in the car are mixed and the front main/auxiliary seats also support heating function. In addition, the new car is also equipped with Living Pilot intelligent assistant system, which includes ACC adaptive cruise, distance keeping function, automatic parking function, car-following start function and other auxiliary functions.

In terms of power, Weimar E.5 adopts a motor with maximum power of 120kW and maximum torque of 240N·m+58.6 kW h ternary lithium battery, and the cruising range of NEDC is 505km. In terms of charging, it takes 39 minutes for DC to charge 30%-80% quickly; It takes 9.5 hours for AC slow charging from 0% to 100%.

Lantu Dreamer will be pre-sold on April 7th.

Dreamer is the second model of Lantu brand, positioning large luxury electric MPV. In terms of appearance, the front face of Lantu Dreamer adopts a large-size straight waterfall grille design, and the symmetrical shape is matched with flat daytime running lights on both sides to create a simple and fashionable visual effect. In addition, the car adds chrome trim around the air inlets on both sides of the bumper to enhance the sports atmosphere of the whole car.

The side design of the new car is relatively flat, and chrome trim strips are added to the window frame, door handle and side skirt to further enhance the overall fashion sense. In terms of body size, the length, width and height of the new car are 5315*1980*1810mm and the wheelbase is 3200 mm. In the rear part, the slender blackened LED taillight group is matched with chrome trim at the tailgate and a wide rear enclosure design, which has strong recognition. It is worth mentioning that the new car also provides a two-color body for customers to choose from. It is reported that its appearance can also be equipped with different styles of wheels and skylights.

The 7-seat version of Lantu Dreamer adopts white/gray double interior color matching, and uses three large-size penetrating displays inside, which is full of science and technology. The 7-seat version of Lantu Dreamer will adopt a 2+2+3 seat layout, and the second row will be equipped with independent seats with armrests. It is reported that Lantu Dreamer is the first to take the 5G car light speed entertainment and office system, L2+ intelligent driving assistance system, and support the OTA of the whole vehicle. The rear seat of the car adopts independent layout, and both passengers can get relatively independent seating space. Not only that, it also provides aviation headrest, electric leg rest and lumbar support cushion.

In terms of power, the Dreamer Extended Range Edition consists of a 1.5-liter turbocharged engine and dual motors. Among them, the maximum output power of the engine is 100 kW, and the peak power of the motor is 130 kW and 160 kW respectively. In addition, the power of the pure electric version of the car is still unknown.

Genie #1

As the first product of the brand’s new electrified product series, Genie #1 is positioned as a pure electric SUV. The new car adopts the design language of "Sensibility and Lingrui", and the overall shape has always been simple and dynamic.

In addition, the new car also uses a hidden door handle, and is equipped with an aerodynamic kit and an active air intake grille, with a drag coefficient of only 0.29. It is worth mentioning that the new Elf #1 has the functions of intelligent starting battery heating and hidden door handle breaking ice, which can ensure the normal use of vehicles in low temperature environment.

In terms of power, Genie #1 is expected to adopt a single-drive motor layout at the rear axle, with a maximum motor power of 149kW and a battery capacity of 60kWh.

The first MPV

The first MPV will be officially unveiled in April. According to the spy photos exposed before, MPV will adopt a brand-new design language, and the overall shape is more fierce. In the front part, the new car is expected to be equipped with a closed grille with irregular headlights on both sides, which is highly recognizable. In addition, the car is expected to be equipped with brand-new front enclosure and front lip components to further enhance its sense of movement.

The side design of the new car is relatively flat and equipped with electric side sliding doors, which ensures the space in the car and makes it more convenient to get on and off. In addition, the car blackens the window frame and uses large-size wheels.

It is reported that the interior of the car will adopt a 7-seat layout of 2+2+3, and the third row of seats can be placed flat. In the power part, MPV will provide DM and EV dual power modes, and the vehicle equipped with DM super-hybrid technology will have a comprehensive battery life of 1,000 kilometers; The EV version is equipped with an 8-in-1 integrated intelligent precursor assembly and a battery intelligent thermal management system.

A whole new generation/i7

The new generation and i7 will be launched in the world in April. As the brand’s first pure electric luxury flagship car in the world, i7 has redesigned classic elements such as headlights and kidney grille to create an emotional appearance. Among them, the daytime running lights above the front of the car are composed of luxurious crystal elements, which are full of impact with the ring-shaped dazzling grille. In terms of power, the new i7 will have a mileage of over 600 kilometers.

The new car will be equipped with the latest generation of BMW iDrive operating system. The car is equipped with an integrated suspended curved screen, an encircling interactive light strip running through the front dashboard and the door, and a newly designed panoramic star-orbit canopy. Users can control the LED light color on the canopy according to their personal preferences. In addition, a 31-inch suspended giant screen is introduced in the back of the new car, and the interior creates an atmosphere of luxury and technology.

According to the news of the 2022 annual financial report meeting of the Group, in 2022, the Group will mass-produce and trial-produce 15 pure electric vehicles; The "new generation" model based on the new structure will start trial production in 2024 and be unveiled in 2025. By the end of 2025, the Group plans to deliver 2 million pure electric vehicles worldwide. In 2030, the Group plans to deliver 10 million pure electric vehicles to customers.

Ideality L9

The ideal L9 will be launched at the auto show, and the price range is expected to be between 450,000 and 500,000 yuan depending on the configuration. The ideal L9 locates the full-size SUV and adopts the second-generation extended-range platform. At the same time, the car is expected to be equipped with a higher-level assisted driving system.

In the interior, the ideal L9 flat-bottomed steering wheel and digital instrument are highly scientific and have a highly recognizable information reading experience. It is worth mentioning that the new car adopts an innovative 5-screen interactive mode, which consists of a standard HUD, a safe driving interactive screen located above the steering wheel, a central control screen, a passenger entertainment screen, and a rear cabin entertainment screen. Among them, three 15.7-inch car-grade OLED screens provide 3K high-definition resolution and extreme color reproduction.

Nezha s

Nezha S will be pre-sold during the auto show. In terms of appearance, the new car adopts a fully enclosed grille with split headlights, which is highly recognizable. The bottom of the front of the car adopts a large-mouth honeycomb front enclosure design, which is very futuristic in combination with the blackened air inlets on both sides. Nezha’s S-side lines are smooth, and the design of sliding back and hidden door handle makes the overall visual experience more dynamic. In terms of tail, the new car penetrating taillight group is designed with black tail lip, which is highly recognizable.

The interior of the new car adopts a four-screen design consisting of 17.6-inch central control screen +12.3-inch co-pilot entertainment screen+HUD head-up display and full LCD instrument. There are almost no physical buttons around the central control, and all functions are integrated on the central control screen. In terms of configuration, Nezha S will provide urban navigation assistance, high-speed navigation assistance, and parking/pick-up functions.

In terms of power, Nezha S is equipped with a front and rear dual-motor design with a peak power of 340kW, and it is available in two types: extended range version and pure electric. Among them, the extended range version of NEDC can reach 1100km, and the pure electric version of NEDC can reach 800km. In addition, the new car also adopts HozonEPT4.0 constant temperature thermal management system, and its Huawei heat pump nine-way valve has 16 working mode combinations, which greatly saves energy consumption.

Tucki G9

Tucki G9 will also open the pre-sale during the auto show. As a new smart flagship SUV in Tucki, G9 is the first model under the latest global design language. The logo design is added on both sides of the new car’s penetrating daytime running lights, just like two very sharp eyes; Four daytime running lights are added up and down the headlights, which look like the LOGO of Tucki. In addition, the car’s dual lidar is perfectly integrated into the headlights and has a richer intelligent interactive light language.

On the side of the car body, the horizontal high waistline of the car runs through the car body, and the application of 21-inch wheels creates a sporty atmosphere of the whole car. In the rear part, the visual effect of G9 blackened through LED taillights is excellent after lighting, and the tail design above the rear windshield also highlights the sports attributes of the car.

In terms of intelligent technology, Tucki G9 is the first production car equipped with XPILOT 4.0 function. In addition, the car’s 5G antenna can make the vehicle faster in data transmission, so as to support high-level intelligent functions such as automatic driving, intelligent cockpit and OTA based on a large amount of data transmission; X-EEA 3.0 can realize the self-inspection of the vehicle before leaving the factory and complete the software update to ensure the software safety.

5min terms of charging speed, the overcharge capacity of the vehicle reaches 200+km after charging for 5 minutes. Thanks to the optimization of high-voltage SiC technology, motor magnetic field and reducer, the highest efficiency of the electric drive system is over 95%. In addition, the vehicle adopts the liquid cooling heat dissipation technology of charging gun, and the flow capacity can reach 670+A, and the IP65 seal level and the built-in safety monitoring chip can jointly ensure safety.

Tiggo 8 PRO

Tiggo 8 PRO is positioned as "the flagship of global power technology" and is expected to be listed in May this year. In terms of appearance, the new car adopts the latest family-style design language, and the overall shape is more imposing. In the front part, the Tiggo 8 PRO adopts a huge blackened air intake grille with a scattering design inside, and it is highly recognizable with the slender headlights and LED strip on both sides of the front. In addition, the new car also adds air guides on both sides of the front enclosure to further enhance its sports properties.

In the rear part, the Tiggo 8 PRO has a full shape, and the through LED taillights are quite recognizable after lighting. In addition, the new car also uses a bilateral four-out tail row to further enhance the sense of luxury and sports attributes. In terms of size, the length of the new car is 45mm longer than that of the Tiggo 8 to 4,745mm, which is more advantageous in terms of space.

In the interior, the Tiggo 8 PRO adopts the driver-centered minimalist design concept, and is equipped with a 24.6-inch curved screen, W-HUD head-up display and SONY luxury 10-speaker surround sound. Among them, the curvature radius of the 24.6-inch curved screen reaches 3000R, which can make the user’s line of sight more concentrated; W-HUD head-up display can display information such as vehicle speed, dynamic ADAS, navigation and telephone.

In the power part, Tiggo 8 PRO will launch 1.6TGDI/2.0TGDI fuel and Kunpeng DHT hybrid power at the same time, and be equipped with "CHERY AWD" full-scene intelligent four-wheel drive system. Among them, Kunpeng DHT hybrid has "3 engines, 3 gears, 9 modes and 11 speeds"; The "CHERY AWD" full-scene intelligent four-wheel drive system is built by ZF, which can provide six full-scene road modes including economy, ordinary, sports, camping, skiing and cross-country.

brand-new

The brand-new will be officially unveiled at the auto show and will go on sale in the second quarter of this year. In terms of appearance, the third generation adopted a brand-new "Phoenix" shape, and a large area of X-shaped grille was filled with "Phoenix Feather" elements. At the same time, the brand-new penetrating headlights used for the first time are connected with the upper edge of the grille, and three sets of vertical turn signals are also designed under the headlights, which are hidden in the front grille, further widening the width of the front face and creating a wider and more domineering visual effect.

The side of the new car adopts a low-lying front shape with a dive waistline, which effectively reduces wind resistance and creates a visual effect of movement. The door is designed with a hidden door handle and the edge is designed with a curved lower waistline, which makes the sideways show a varied curved surface effect and increases its aesthetic feeling. In addition, the third generation has four wheel hub shapes, and also offers three tire sizes including up to 20 inches.

The new third-generation tail has distinct layers, and the overall outline of the tail presents an outward-looking shape, which echoes up and down with the upper split spoiler and the bottom three spoilers, showing the sports personality; With two inverted trapezoidal exhaust shapes at the bottom, the overall visual effect is quite fashionable. In the power part, the new car is equipped with a 1.5-liter turbocharged engine with a maximum output of 138 kW.

OMODA 5

As the first model of the global OMODA series, OMODA 5 is expected to be listed in China in the second quarter of this year. The exterior of the new car is designed with a borderless air intake grille and the interior is distributed with inverted trapezoidal broken lines, which has a scientific and technological atmosphere. In addition, the interior of the grille of the new car is decorated by a large number of rectangular units, and the dense modeling design also has a popular conceptual style. At the same time, the two sides of the car are designed with split headlights, and the upper part of the front face is filled with integrated through light strips, which makes the lighting effect very scientific and technological.

The side of the car body adopts a slip-back body structure, and the 18-inch multi-spoke sports color contrast rim adopts a blade design, which is decorated with black and blue color contrast to create a strong sense of movement. At the same time, the car also added a suspended roof design, which is full of fashion. It is worth mentioning that the OMODA 5 tail is designed with triangular taillights, and the dot-matrix light source inside the light group also has the effect of running water turning lighting, which is highly recognizable.

In terms of interior, the new car also continues the design concept of the meta-universe. The contrast design of the interior and the crystal bumper have improved the interior texture of the car, and the popular double flat design has also been applied in this car. In addition, the adjustment button under the air outlet of OMODA 5 air conditioner adopts light touch design, and with the flat-bottomed three-position multi-function steering wheel, the whole interior looks simple without losing the sense of technology. In terms of power, the new car is equipped with a 1.6T turbocharged engine developed by Kunpeng Power, with a maximum power of 145kW and a peak torque of 290 N m..

Write at the end:At present, due to the blessing of the auto show, the launch of new cars in the second quarter is mainly concentrated in April. However, due to various factors such as the epidemic situation, the auto show is uncertain, and there is a high probability that it will be postponed, and the pace of new car launch will be disrupted, and we can only wait for good news. This time, the new cars in the second quarter are worth looking forward to in terms of scale and product diversity. Which one is the most exciting for you?

(Photo/Text Netcom Zhou Yue)

Lei Jun, Chairman and CEO, announced that Xiaomi Automobile Technology Conference will be held on December 28th.

In today’s era when technology is changing with each passing day, the automobile industry is also undergoing unprecedented changes, and electric vehicles (EV) are becoming a new technology hotspot. Xiaomi Group, a technology giant that started with smart phones, has now officially entered this highly competitive field. In March 2021, Xiaomi announced that it would enter the automobile industry. Since then, the progress of Xiaomi Automobile has been receiving much attention. Now, with less than half a year to go before the mass production of Xiaomi’s first car, Lei Jun, founder, chairman and CEO of Xiaomi Group, announced that it will hold a Xiaomi car technology conference at 2 pm this Thursday, which will be the first official appearance of Xiaomi car.

The technical conference of Xiaomi Automobile is a milestone, which marks the official debut of Xiaomi in the automobile industry. Although the theme of the conference is technology rather than products, it still shows that Xiaomi has made remarkable progress in automotive technology and is ready to share these achievements with the public and the industry. Lei Jun’s circle of friends further emphasized the importance of this point, and his words revealed his confidence in Xiaomi’s automobile technology.

Before this conference, Xiaomi Auto’s official social media account has been launched, which indicates that Xiaomi Auto’s brand building and marketing activities have started, and Xiaomi is preparing to enter the vast auto market. In the latest Catalogue of New Energy Vehicles Exempted from Vehicle Purchase Tax issued by the Ministry of Industry and Information Technology, the information of Xiaomi’s first model SU7 was officially disclosed, which further deepened the public’s expectation for Xiaomi.

The technical parameters of Xiaomi SU7 show Xiaomi’s ambition in electric vehicle technology. Two kinds of battery packs with different capacities and different cruising ranges, as well as technical support to BYD and Contemporary Amperex Technology Co., Limited, two major battery manufacturers, all show Xiaomi’s in-depth research and cooperation in battery technology of electric vehicles. In particular, the options of different battery capacity and different vehicle kerb quality provide responses to different market demands.

Judging from Lei Jun’s promise, Xiaomi Automobile will show cutting-edge technology and high-level manufacturing capability when it is released. This commitment is not only a strong signal to consumers, but also shows the automobile industry that Xiaomi is a new competitor with foresight and strength. Xiaomi’s brand influence and successful experience in the field of intelligent hardware may bring new innovation and vitality to the automobile industry.

All in all, the upcoming technical conference of Xiaomi Automobile is a key moment in Xiaomi’s journey into the automobile industry. It will not only show Xiaomi’s latest achievements in automotive technology, but also lay the foundation for the market launch of Xiaomi’s first mass-produced car. With the official appearance of Xiaomi Automobile, we have reason to expect how Xiaomi will show its innovative spirit and technical strength in this new field full of challenges and opportunities.

Creative Opening of 2024 China (Hangzhou) Outdoor Camping Life Exhibition

Promote Hangzhou to build a highland of outdoor industry quality in China

On the morning of March 22nd, 2024, CLE2024 China (Hangzhou) Outdoor Camping Life Exhibition ("CLE 2024 Hangzhou Exhibition") kicked off at Hangzhou International Expo Center with a simple but creative outdoor fashion show. From March 22nd to 24th, more than 200 exhibitors and more than 300 brands participated in the event, and the organizer also organized 10 themes and over 80 heavyweight events to be staged in 9 major spaces, showing the overall development trends of outdoor industry in China.

Since 2023, CLE Hangzhou Exhibition every spring has become an important industry activity of outdoor industry in China. According to the exhibition data released by the organizing committee a few days ago, during the three-day exhibition, all exhibitors will, together with industry practitioners, enthusiasts, relevant competent departments and major Internet platforms, comprehensively explain all kinds of industry information of China’s outdoor sports industry in equipment manufacturing, platform sales trends, and the direction of choosing people to bring goods, share the experience of organizing and operating camps and outdoor activities, carry out international exchanges, fully experience the latest equipment for outdoor catering and outdoor travel, and feel the complete and full outdoor culture.

With the theme of "Connecting Outdoor Life", this CLE 2024 Hangzhou Exhibition focuses on the e-commerce, cross-border transaction and internationalization of outdoor industry, which provides a new industry idea for the sustainable development of outdoor industry in China. According to incomplete statistics, there are nearly 1,000 people who have signed up for CLE 2024 Hangzhou Exhibition, and the total number of fans has exceeded 150 million, accounting for about 1/3 of the outdoor population in China. At the same time, exhibitors and camp owners from more than ten countries including Russia, Mongolia, Kazakhstan, Singapore, Malaysia, Canada, Japan, Australia and the Middle East visited the exhibition site.

Focusing on promoting and popularizing outdoor culture is another major feature of CLE 2024 Hangzhou Exhibition. A brief history of camping, the first general book in China to introduce the 150-year development of outdoor camping industry, was launched at this CLE 2024 Hangzhou Exhibition, and the creator and publishing agency China Academy of Fine Arts Press signed a sale for the audience on the spot. At the same time, the CLE Camping Museum was jointly established by several exhibitors at the exhibition, which provided a space for industry visitors and enthusiasts to understand the historical development of outdoor camping.

As a manufacturing highland in China, Zhejiang is also a gathering area of outdoor camping industry. At the CLE 2024 Hangzhou Exhibition, the audience can also see the product displays from Sanmen, the capital of China jackets, and several industrial belts.

Since 2020, Hangzhou has become the benchmark of exquisite camping and outdoor leisure life in China, and many representative camps have gathered around the city. In three days, CLE 2024 Hangzhou Exhibition brought together industry practitioners from all over the country and around the world to focus on the status quo and challenges of China’s outdoor industry, and put forward solutions and solutions from the perspective and methods of China, which will further boost Hangzhou’s construction into a high-quality outdoor industry in China.

Attachment: Summary of CLE 2024 Hangzhou Exhibition

CLE 2024 Hangzhou Exhibition Site Activity Arrangement

Time: March 22-24, 2024

Venue: 3F, Hangzhou International Expo Center

I. Layout of the Exhibition

CLE2024 Exhibitor Booth Distribution Map

Second, the 9 major activity spaces of the exhibition

In order to present the outdoor camping lifestyle in an all-round way and create a better on-site environment for industry exchange and docking, nine activity spaces were set up in the venue of CLE 2024 Hangzhou Exhibition, namely:

"grow good business" outdoor forum area

"City Outdoor" Picnic, Coffee, Wine and Chill Moment

Aesthetic natural education of "Learn Shan Ye with pleasure"

"Outdoor Partner" Lifestyle Community

Outdoor life model room "wilderness home"

Outdoor camping sea ecological zone

CLE& Xiaohongshu blogger guest contact area

Product selection area for bloggers with goods

CLE outdoor camping museum

III. Summary of participating brands

CLE2024 Exhibitor Brand List

IV. CLE 2024 Hangzhou Exhibition Schedule

CLE2024 exhibition tour guide

V. Contents of "Planting Good Business" Outdoor Forum Area

01 Shan Ye audio • Music scene

02 "Natural Opening" Outdoor Fashion Show

Jointly launch outdoor fashion show with KOL, anchor with goods and brand exhibitors, and open the preface of 2024CLE.

Look at the 150-year camping history — — Press conference of the new book "A Brief History of Camping"

The first book in China that systematically introduces the 150-year history of camping, A Brief History of Camping, was released and recommended by the promoters and practitioners of outdoor lifestyle in Nomori territory.

Decryption of China Outdoor Brand E-commerce Operation — — Domestic e-commerce platform sharing

"Tik Tok" Tik Tok E-commerce Outdoor Camping 2024 Trend Release

Dong Yunlu Doris Dong-Head of Business Transportation in Camping Industry of Tik Tok E-commerce Brand Group

"Little Red Book", "Everything grows in the wind" Little Red Book Sports Outdoor Inspiration Marketing Sharing

Mingjun-Xiaohongshu Commercial Fashion Clothing Industry Sports Outdoor Integrated Marketing Expert

"Tmall" 2024 Tmall camping trend sharing

Cherish life-head of Tmall camping

New businesses in "Aauto Quicker" have new operations and new growth.

Yu Ailin-Aauto Quicker is the operation director of "Official Assistant of Magnetic Taurus" and the operation director of "Jinniu Classroom".

The growth trend of outdoor sports with "getting things"

Muyi-Dewu Outdoor Category Operation Experts

05 CLE outdoor brand promotion special session

"Outdoor Power Supply and Outdoor Electricity Consumption Ecology"

Leng Xiaowei-General Manager of Shenzhen Yizu Innovation Technology Co., Ltd.

"It’s just the right time to go out to sea-avoid the winner’s thinking of getting involved and going out"

Li Hualin-CEO of WebTV Asia Grape Media Greater China

"Introduction of the Famous City of Jacket Clothing in Sanmen County"

Li Lujia-Deputy Director of Sanmen County Investment Promotion Center

"To help outdoor products go to sea, how to save logistics costs from the source? 」

Wang Letian-General Manager of Xiyou Logistics East China Branch

"Canadian outdoor lifestyle"

Grace-Founder of Smypark Canada Limited

"Canadian health functional food SunDrench brand sharing meeting"

Shangduoli (Hangzhou) International Food Technology Co., Ltd.

"SP1KE New Technology Released for External Protection of Customers"

Canada SP1KE company

"The Next Fifteen Years of Black Deer"

Ye Xiao-Black Deer Brand Manager

"Keep Walking: The Road of Fire Maple Research and Development"

Qin Yu-Head of Brand R&D of Huofeng

"Introduction of Nujiang outdoor sports industry project".

Zhang Xuelian-Deputy Director of Nujiang Education and Sports Bureau

"Introduction of throwing Frisbee"

An Chenran-Founding Partner/General Manager of Wing Kun Frisbee

"Star Navigator: A Journey of Astronomy and Space Exploration in Mars Camp"

Feng Jiang-Mars camp co-founder camp director and general manager of Cold Lake Astronomy.

"Open your heart and fly, and you will naturally respond."

Wei Xiaoliang-I fly outdoor COO

"pot ring brand sharing"

Guo quan Shi hui

"brand sharing of Harajuku self-operated factory"

Harajuku

"What else can I eat for a healthy outdoor life? See how camping scenes keep pace with "food"

Amanda-ELMJOY Yu zhiyu brand promoter

"Wolf Brand Story"

Ma Haozhe-Founder CEO of Wolf

06 Outdoor Wind Blows the World — — There are new tricks for cross-border going to sea, and nine platforms face each other.

Deep analysis of all categories of Amazon outdoor sports in "Amazon opens stores worldwide"

Sunny Zhou-Senior Manager of Key Account Development and Operation Management of Amazon

"eBay" E-way peers, everything is fine. Introduction of Bay-eBay2024 platform and outdoor category sharing.

Zhang Haoyuan-Business Development Manager of eBay Greater China

Introduction of "TikTok Shop" Full Hosting Mode and Promotion of Outdoor Sports Category

Chen Yongkuo-Outdoor Investment Manager of Tiktok Shop Cross-border E-commerce Campaign

"Wal-Mart" is outdoors in "Wo", and it is just the right time to go to sea.

Weiwei Chen-Wal-Mart Global E-commerce Strategic Channel Development Consultant

"Coupang" and Coupang, Nuggets "Sports Outdoor" New Business Opportunities

May Gao-Coupang, Head of Investment Promotion in East China

Introduction of "Lazada" Full Trusteeship Mode and Promotion of Outdoor Sports Category

Dai Guisheng-Lazada, Investment Manager of Outdoor Sports in Full Trust

"Meikeduo" went out to sea to dig gold in Latin America.

Max-Mercado China East China Business and Regional Development Manager

"Shopee" makes every possibility of outdoor camping in Southeast Asia.

Elaine (Pang Yiyue)-Shopee Investment Promotion and Incubation Manager

"Lotte Japan" went out to sea in Japan and chose Lotte Japan, a cross-border e-commerce treasure platform.

Wu Feifei-Investment Manager of Lotte Group Shenzhen Branch, Japan

07 2024 Spring Camping Conference of Pot Circle Food Exchange

One-stop solution promotion of pot camping life, first release of new pot products, investment promotion policy of pot camping shop, cooperation and signing of 100 camping plans, etc.

08 Let’s meet — — All-in-one exchange meeting of cultural, sports and tourism

The sharing of diversified outdoor life, the introduction of China Road-Zhejiang Station, the signing ceremony of 2024 Association’s self-driving market operation and government cooperation, and the promotion of local self-driving and camping destinations.

09 camp product and content innovation — — Campsite building logic

International experience of combining youth camp and holiday camp in "international outdoor emerging market"

Former President of Valery Kostin-ICF International Camp Association

Valerii Dolgikh-President of Russian Camp Association

Abdumukhtorov Anvar Akramovich-Director of Leisure and Rehabilitation Department of Uzbekistan

Bymba Chultem-Chairman of Mongolian Camp Association

Duan Diandian-Secretary General of ICE Camp Research Institute

How can outdoor camping empower rural revitalization?

Manager of Baoxin-Xiaohangkeng Camp

"Camp Planning and Design" The Core Elements of Camp Planning and Design

Dai Zheng-good morning, founder of Yesu

"Camp diversification case" Camping new era, camp diversification development model

Jingliang-Founder of Camp Club

"Chain Camp Case" Hi King Camp, Chain Development

Cui lianbo-hi, founder of King chain camp

Construction of camp products of "comprehensive camp operation case"

Tang Wei-Niulu Camping & Founder of Niulu Outdoor Education, Ph.D. in Tourism Hotel Management, Hong Kong Polytechnic University, and chinese mountaineering association Youth Outdoor Education Tutor.

Looking for the most beautiful camp in China to see the trend of camping and outdoor sports

Zhao Jingwen-Founder of Camping Season

How to plan a competitive campsite in the era of consumption degradation?

Mingli-General Manager of Shanghai Kemu Design

10 Connecting Outdoor Life — — Lifestyle innovation

"Cross-border Outdoor" Australian Camping Mode Sharing

TIM CUTLER – AOA

"outdoor research" outdoor research scene and content (Camping in Trent)

Kelly-Head of Admissions, Trent University, China

"Outdoor travel" Vala may be more free.

Fang Fang-co-founder of Vala

"Outdoor Climbing" into No Man’s Land, Antarctic Exploration and Protection

Bin Sun-Founder of National Mountaineer Peak Outdoor Sports School

How much face can the new trend of "outdoor wearing" bring?

Founder of Bi Yiran-UPPERVOID’s Second Latitude

VI. Other supporting activities

(A) interactive punching activities

"CLE 2024 Hangzhou Exhibition", in conjunction with Xiaohongshu and Tik Tok Platform, organized a number of interactive and punching activities in the same period.

(B) On-site outdoor activities experience and teaching

"CLE 2024 Hangzhou Exhibition" has joined more than 10 outdoor sports, outdoor education and outdoor experience institutions, and there are nearly 20 outdoor activities and community activities on the spot to open the experience to the audience.

(3) Pet-friendly

CLE 2024 Hangzhou Exhibition continued the pet-friendly policy. All kinds of pets that meet the pet management policy of Hangzhou can enter the venue after reporting in advance. The organizing committee of CLE 2024 Hangzhou Exhibition also set up a special pet-friendly area to serve the visitors’ pet storage.

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The General Administration of Financial Supervision voiced its support for real estate! The plate rose more than 3%, and Pudong Jinqiao 4 was connected to the board.

On January 26th, the real estate sector opened higher, with Pudong Jinqiao (600639)(600639.SH), China Enterprise (600675)(600675.SH) as four boards, Everbright Jiabao (600622)(600622.SH) and Waigaoqiao (600648).

In the news, since 2024, relevant policies on financial support for the reasonable financing needs of the real estate market have been intensively introduced. On January 12, the Ministry of Housing and Urban-Rural Development and the General Administration of Financial Supervision jointly issued the Notice on Establishing a Coordination Mechanism for Urban Real Estate Financing; On January 24th, the Central Bank and the General Administration of Financial Supervision jointly issued the Notice on Doing a Good Job in the Management of Operating Property Loans.

Ensure the smooth operation of the real estate market

According to the General Administration of Financial Supervision, up to now, the balance of real estate development loans and personal housing loans in China is 12.3 trillion yuan and 38.3 trillion yuan respectively.

In 2023, Chinese banks issued 3 trillion yuan of development loans and 6.4 trillion yuan of housing mortgage loans respectively, which add up to nearly 10 trillion yuan.

In addition, last year, banks also provided real estate enterprises with M&A loans and stock extension loans, which added up to more than 1 trillion yuan.

As for Baojiaolou, by the end of 2023, most of the 350 billion yuan special loan for Baojiaolou has been put into the project, and commercial banks have also provided corresponding commercial supporting financing to ensure the smooth completion of the task of Baojiaolou.

Continue to provide financial support.

Next, the state will continue to provide financial support for the real estate market.

The General Administration of Financial Supervision said that in the future, the coordination mechanism of urban real estate financing will be accelerated and effective. Under the lead coordination of the government, push the list of real estate projects that can be given financing support to financial institutions in the region.

At the same time, guide financial institutions to further implement the management requirements of operating property loans. For real estate development enterprises with standardized operation and good development prospects, banks are allowed to issue operating property loans to them, which can be used to repay the stock loans of housing enterprises and the open market bonds they issue before the end of 2024.

In addition, we should continue to do a good job in personal housing loan financial services, support local governments to make policies according to the city, further optimize personal housing loan policies such as down payment ratio and loan interest rate, and urge banks to better serve the financing needs of people’s rigid and improved housing.

Guide banks and other financial institutions to continue to vigorously support the construction of "three major projects" such as "emergency and emergency" major infrastructure and urban village reconstruction, and form a physical workload as soon as possible.

Multi-share daily limit of real estate sector

Thanks to favorable policies, the real estate sector has also shown signs of stabilizing, and brokers are generally optimistic about the allocation opportunities of the real estate sector.

Open source securities said that the fundamentals, valuation level, allocation ratio and market expectation of the current real estate sector are at a low level, and the policy window period is worthy of attention. Follow-up can pay more attention to strong credit housing enterprises with excellent layout, high investment intensity and marketization mechanism.

Founder Securities believes that the valuation of the real estate sector is in a historically low range, the industry has a good policy environment for stabilization, and the resilience of the sector rebound is sufficient. In addition, the fundamentals of the whole sector have structural support, and the real estate sector is expected to continue to rebound under the catalysis of favorable policies. You can focus on the theme of Pudong reform, second-hand housing track, high dividends and so on.

From the perspective of disk performance, the performance of individual stocks superimposed with the concept of Shanghai Free Trade Zone is more eye-catching. Among them, Pudong Jinqiao, Chinese enterprises, etc. have gone out of the fourth board, and Everbright Jiabao, Waigaoqiao and other stocks have also won the third board.

As of noon on January 26th, the real estate service sector rose by 3.79%, and the real estate development sector rose by 3.32%.

Reporting/feedback

International Football League Cup Comprehensive: Arsenal and Manchester United missed the quarter-finals.

Xinhua News Agency, London, November 1st (Reporter Zhang Wei) Arsenal and Manchester United both lost to opponents from the same Premier League on the 1st, and missed the quarterfinals of the English League Cup.

Arsenal played against West Ham United in London on the same day, and fell behind in the first half because of White’s careless own goal. "Arsenal" coach arteta bluntly said after the game that the ball directly influenced the development direction of the game. Since then, Arsenal, which has an absolute advantage in possession of the ball, has never been able to make a breakthrough. On the contrary, Kaddos added another point five minutes after the West Ham United Easy Side, extending the lead to 2-0. In the 60th minute, Bowen hit a long-range shot outside the penalty area. It wasn’t until the final stoppage time that Arsenal were pulled back by substitute Odegard, and the score was fixed at 1-3.

On November 1st, Arsenal coach Arteta looked depressed after the game. Xinhua News Agency/Reuters

Manchester United, who just suffered a home defeat in the Manchester derby last weekend, continued to sink at Old Trafford. Against Newcastle United, they conceded two goals in a row in the first half. In the 60th minute, Willock got rid of the defense with the ball in the frontcourt and hit the door to help the Magpie achieve a 3-0 victory.

Newcastle, who lost to the "Red Devils" in the Carling Cup final last season, took revenge, and their quarter-final opponent will be Chelsea who beat Blackburn 2-0 on the same day.

In addition, Liverpool beat Bournemouth 2-1 with goals from Gakpo and Nunez, and the quarterfinals will face West Ham United.

Do you still need a structural biologist with AI? Wait for the top experts in Shi Yigong to see it this way.

Recently, Yan Ning, a famous structural biologist, announced that he would resign from Princeton University and set up the Academy of Medical Sciences in Shenzhen. In response to the latest research that she will focus on when she returns to China, she said that the discovery of structural biology is of great significance to the pharmaceutical industry, including the research on the interaction between drugs and hormones, which has more implications for drug development and disease treatment.

Yan Ning said, for example, that through the method of structural biology, scientists saw for the first time that two commonly used drugs used protein as a "scaffold", which directly "side by side" affected the normal function of protein.

Technological change promotes the development of structural biology.

Protein, as the scaffold and main substance of human tissues and organs, plays an important role in human life activities. In the cell, a large number of protein elements form the molecular machines, which performs important molecular processes in the cell through the interaction of protein, including the cell’s response to the external environment and the internal environment, and also forms a signal transduction network system with the interaction of protein as a link.

Structure By studying the three-dimensional structure, dynamic process and biological function of biological macromolecules, biology can provide more details of protein interaction and real-time dynamic process, thus helping scientists to understand molecular mechanism and explore the pathogenesis of diseases related to macromolecular dysfunction.

The development of biology not only contributes to the discovery of drugs, but also affects the research fields of life sciences including biochemistry, cell biology, genetic development, neurobiology, microbiology and pathopharmacology.

The development of science and technology has been promoting the progress of structural biology. In 2017, the Nobel Prize in Chemistry was awarded to cryoelectron microscopy, which can greatly improve the efficiency of analyzing the atomic resolution three-dimensional structure of large protein complexes; Moreover, researchers can freeze biomolecules in motion and visualize their motion process.

This breakthrough has brought a perfect storm to the field of structural biology. In recent years, important breakthroughs have been made in the field of life sciences. The work of China scientists such as Cheng Yifan, Shi Yigong, Yang Maojun and Liu Zhengfeng has also benefited from this technology. They have analyzed the important complex structure of atomic resolution. In addition, the enzyme that produces the protein that leads to Alzheimer’s syndrome was analyzed by cryomicroscope.

In August, 2015, Shi Yigong’s research team published an article in Nature, reporting the three-dimensional electron microscope structure of human γ -secretase with a resolution of 3.4 angstrom, and studying the function of the pathogenic mutant of γ -secretase based on the structure analysis, which provided an important foundation for understanding the working mechanism of γ -secretase and the pathogenesis of Alzheimer’s disease.

In February, 2020, after the outbreak of COVID-19, the research team of West Lake University successfully analyzed the full-length structure of novel coronavirus receptor ACE2 for the first time by using cryo-electron microscopy, which helped the research and development of drugs in COVID-19.

What does AI predict protein folding change?

With the help of artificial intelligence technology, DeepMind, a subsidiary of Google, recently announced 220 million kinds of protein structures predicted by AlphaFold software, which shocked the field of structural biology, because it indicates that artificial intelligence enterprises have begun to "truly hand over the power of Al to scientists all over the world".

Scientists compare the significance of this disruptive breakthrough with the human genome project. In the 1990s, when the Human Genome Project began to take shape, scientists realized that it was not enough to master the base arrangement of genes, but also to know the protein, the product of genes.

Shi Yigong, academician of China Academy of Sciences, structural biologist and president of West Lake University, commented on AlphaFold’s work: "Its accurate prediction of protein structure is the greatest contribution of artificial intelligence to the scientific field, and it is also one of the most important scientific breakthroughs made by mankind in the 21st century."

Shi Yigong once told China Business News: "AlphaFold represents the world’s leading artificial intelligence protein organization prediction system." At the same time, he said, China’s high-tech enterprises are catching up, expecting to bring surprises to the world in the near future.

He also said that the improvement of the accuracy of protein structure prediction will greatly benefit the pharmaceutical industry. "Artificial intelligence prediction of protein structure provides an important foundation for drug design and optimization. The structure of drug target proteins combined with all small molecule drugs can almost be wiped out by AlphaFold. " Shi Yigong said.

In the opinion of some scientists, although AlphaFold’s work is shocking, the accuracy of drug research and development prediction is not enough. Professor Liu Zhijie, executive director of iHuman Institute, Shanghai University of Science and Technology, told the First Financial Reporter: "It has been a long time to predict the protein structure. Now the accuracy of the prediction is definitely getting higher and higher, but it still hasn’t reached the precision of crystal structure."

Liu Zhijie First Financial News told the reporter that the crystal structure is the most accurate, and now artificial intelligence can predict the protein folding with the accuracy of electron microscope and nuclear magnetic resonance. In addition, because there are thousands of structures in protein, the difficulty of analysis is different. "If some protein sequences are similar to the known structure of artificial intelligence, it is easier to predict." Liu Zhijie said.

However, he still believes that with the continuous improvement of the prediction accuracy of protein folding, it will play a more important role in the field of life sciences in the future. "If the current prediction can reach the accuracy of electron microscope, some drugs can already be designed. Drug design is the biggest application field of artificial intelligence protein folding prediction." Said to Liu Zhijie First Financial Reporter.

Others think that with the development of artificial intelligence, there may not be so many structural biologists in the future. "Many researchers who do structural biology are actually more like technical service personnel. The more people there are, the more structures that can be analyzed. Therefore, in essence, a large part of their work depends on manpower. Now with AI, it is true that a large number of people who do structural biology have changed careers." A virus researcher told the First Financial News reporter.

However, for top structural biologists such as Shi Yigong, technology is only a powerful support for the "top brain", which can help them realize more ideas. "Every conscientious biologist should know how to make good use of the structural prediction of artificial intelligence." Shi Yigong said.

Professor Michael Levitt, winner of the Nobel Prize in Chemistry in 2013, told China Business News: "I think many structural biologists are not only doing structural research, but also doing a lot of work on protein function and drug research and development, just like Professor Yan Ning. Artificial intelligence only liberates a part of traditional manpower, but the progress of science still needs to rely on the smartest human brain. I’m afraid that artificial intelligence alone will not work. "

In recent years, a number of AI pharmaceutical companies have also been born in China. In this regard, Ewing Nan, academician of Chinese Academy of Sciences and president of Beijing Institute of Scientific Intelligence, pointed out to the First Financial Reporter: "The emergence of AI for Science research paradigm is an important historical opportunity for scientific and technological innovation, which not only expands the capability boundary of data-driven and physical model-driven models, but also is expected to promote the organic combination of the two, provide theoretical basis for further solving practical problems, and greatly narrow the distance between scientific research and practical application."