[Global Network Technology Comprehensive Report] "What we are about to see in this JD.COM 618 is that the omni-channel from online to offline and the whole link from consumption to industry share quality consumption; From the city to the countryside and from the back wave to the silver hair, the whole scene from home to the store shares a good life, so that love is not limited to consumption. " Kai Chen, vice president of JD.COM Group, said at the launch and trend conference of 2021 JD.COM 618 held on May 20th that he also released seven major consumption trends of JD.COM 618 in 2021.

According to him, in the future, JD.COM will cooperate with various partners such as brand merchants, industrial belt factories, rural farmers, physical stores, etc., and it is expected that 20 million people in the whole industrial chain will participate in the preparations for the "618", helping nearly 200 industrial belts to develop sales channels and realize digital upgrading.

Trend 1: consumption backflow: the rise of national tide, buying the world freely

This JD.COM 618, an escalating and expanding domestic market, is attracting more consumption abroad back to China.

On the one hand, driven by cultural self-confidence and the upgrading of manufacturing in China, consumers have gone from pursuing foreign brands to setting off the fashion of "national tide aesthetics", and a large number of brands of China time-honored brands and new domestic products have risen rapidly. According to JD.COM Big Data, compared with the year-on-year growth of international brands, in 2020, the turnover of China brands increased by 6%, the number of brands increased by 5%, and the number of users increased by 18%. Among the top ten hot spots of consumer brand search, "national products" occupy 7 seats, among which brands such as Huawei, Xiaomi, Maotai, OPPO, vivo, Glory, Gree, Li Ning and Wuliangye are the most concerned.

Behind the accumulation of domestic brands, the help of e-commerce platform is indispensable. For example, in the next three years, JD.COM Seconds will focus on incubating 100 domestic brands, and at the same time, it will support over 30 industrial belts in the next year to build brands of origin, achieving an annual growth rate of over 100%.

On the other hand, under the new development pattern, JD.COM International has unblocked the circulation barriers between domestic and foreign markets through an efficient international supply chain system, helping more and more high-quality imported goods to enter China and meet consumers’ more diversified and higher-quality consumption needs.

Quality is still the core demand of import consumption. According to big data, on the international platform of JD.COM, beauty and skin care, medical care, mother and baby are the most concerned categories, accounting for nearly 70% of the consumption. At the same time, the category structure of imported consumption is more perfect and rich, and pet life, computer office and other categories are growing rapidly.

Trend 2: omni-channel: full bloom, accelerate the destruction of the circle

This JD.COM 618, the "omni-channel" connecting the whole scene online and offline, is accelerating to blossom in the direction of all regions, all customers and all categories.

"Omni-channel" integrates a wider range of online and offline channels, resources and capabilities, and accelerates the expansion to all regions. At present, JD.COM, a subsidiary of Dada Group, has linked more than 100,000 offline stores, covering about 1,400 counties and cities across the country, and the convenient consumption experience of one hour is favored by more and more consumers. In the recent promotion for the 415th anniversary of JD.COM’s arrival, the sales of the platform reached 2.3 times of the same period of last year. In the low-tier cities where the platform has been online for one year, more than 90% of the sales during the promotion period more than doubled compared with last year.

At present, the omni-channel has changed from the core group of married working mothers born in 1980s to more middle-aged and elderly, male and sinking users, and the user structure has become more diversified and expanded to the whole customer base.

Omni-channel is expanding from the core categories of FMCG such as food and beverage, fresh food, household cleaning and personal care to all categories. At present, mobile phones are the fastest-growing category in JD.COM’s home-to-home platform sales, and the number of online mobile phone stores has exceeded 6,000. During the promotion period on April 15th this year, brands such as Apple, vivo, Xiaomi, OPPO and Yijia all increased by more than 7 times year-on-year. In the field of beauty, JD.COM has launched more than 3,400 beauty offline stores at home; In the field of clothing, it has covered over 700 short-term stores.

This year, JD.COM 618 will link more than 3 million offline stores, including not only seven fresh supermarkets, Jingdong House, JD.COM convenience store, JD.COM Super Experience Store, Beijing-Tokyo Auto Club and other offline formats in JD.COM, but also various offline small and medium-sized businesses such as pharmacies, convenience stores, flower shops and auto repair shops nationwide.

Trend 3: new category: precise innovation, satisfying individuality.

In this JD.COM 618, young people have gradually become a new force in the consumer market, and innovation to meet individual needs is more active and accurate.

Midea’s low-sugar and high-fiber "light-eating" rice cookers, Cobos sweeping robots that can automatically collect "moon-throwing" garbage, and GoPro sports cameras that can easily shoot large films outdoors … The new circles and preferences of young consumers bring opportunities to new categories in market segments. With the in-depth insight into consumer demand and the help of the whole life cycle in JD.COM, brands prefer C2M mode. These new products are "explosive when they debut" and new products and categories are accelerating "circle breaking".

Jingmeng, a new brand owned by JD.COM, which focuses on pet categories, also quietly went online in 618. The design perspective follows the physiological habits of pets, and continuously pays attention to the two-way emotional needs of people and pets, making pets easier and happier. Jingmeng intelligent fresh air pet bag not only creates a "mobile RV" for pets to travel safely, but also is the owner’s fashion accompanying bag. A canned pet snack not only contains tuna caught in the deep sea, but also specially adds fish roe, which improves the nutrition and palatability of pet food.

This year, JD.COM 618 will help at least 1,000 new categories to grow by over 100% year-on-year, and 100 new categories will sell over 100 million yuan, so that new products can stand in the "C position".

Trend 4: rural revitalization: consumption improves quality and industry promotes agriculture.

This JD.COM 618, JD.COM and its ecological partners will continue to build a closed loop of "helping farmers to increase their income and promote rural consumption", and promote a virtuous circle of "improving their consumption capacity and enhancing their willingness to consume". Through the "Plan of Prospering the Rich and Promoting the Growth of Rural Trillion Output Value", rural revitalization will be promoted in an all-round way in three years.

Broadening the sales channels of agricultural products is the key to rural revitalization. JD.COM is taking various measures to help more agricultural special products and services integrate into the national market. JD.COM Dashangchao will build a large and medium-sized platform for the circulation of agricultural products, which will help more than 30+ agricultural industrial belts to upgrade their industrial systems in 2021, form a demonstration zone of agricultural industrial belts, and build benchmark products. Jingxi introduced policies such as direct production of agricultural products and direct mining of farmers, and comprehensively promoted the origin of agricultural products to create a new digital industrial belt. Jingdong Logistics focuses on more than 530 agricultural specialty sites across the country, so that high-quality agricultural products in rural areas can be sold and shipped. Based on the intelligent agricultural operating system of Jingdong Smart City, AI and big data are used to help local governments solve the problems of "what is there, what to plant, how to plant, what to sell, how to sell and sell well".

At the same time, Jingdong Logistics has continuously improved the accessibility and service timeliness of the sinking network, so that consumers in township areas can also enjoy the same quality goods and services as people in the city. In counties, towns and villages that have been upgraded to 24 hours, the growth rate of consumption volume is significantly higher than the national average growth rate.

Trend 5: Responsible consumption: green intelligence, sustainable development

This JD.COM 618, in addition to providing goods, more retailers and brands hope to pass on the concepts of sustainable development and social responsibility to consumers and promote the high-quality development of the entire consumer market.

JD.COM practices the concept of "responsible consumption" by building a lower carbon and cleaner supply chain system. On the occasion of the release of the first ESG report, JD.COM Group also issued a carbon reduction declaration, actively responding to the national strategy, and committed itself to becoming a leading enterprise in carbon reduction. At the end of 2019, Jingdong Logistics took the lead in announcing its participation in the "Scientific Carbon Target" initiative, becoming the first logistics enterprise in China to commit to setting scientific carbon targets; In November 2020, the carbon reduction target for 2030 was set: compared with 2019, the total carbon emissions will be reduced by 50% by 2030. Up to now, driven by the "Qingliu Plan" of Jingdong Logistics, recycling packages such as ambient temperature qingliu box and recycling fresh incubator have been used for 110 million times, saving about 2 billion express cartons, with more than 200,000 merchants and hundreds of millions of consumers participating. At the same time, JD.COM’s "Idle Materials Donation Program" has recycled 10 million cartons in more than 100 cities, reducing carbon emissions by 17,500 tons.

At the same time, as a pioneer of environmental protection, jingdong cloud has obtained many invention patents in the fields of energy saving and energy recovery in data centers. Jingdong Smart City has helped Nantong City, Jiangsu Province to build the country’s first modernization center for urban governance, which not only solves urban governance problems, but also helps the city to be green and environmentally friendly, save energy and reduce emissions.

Trend 6: Goods+Services: Trust dominates life without worry.

In this JD.COM 618, it has become the consensus of the industry to create an integrated consumption scene of goods and services. Service consumption has become a new kinetic energy for economic growth and structural upgrading, and new service consumption patterns are constantly emerging.

At present, the life service in JD.COM has covered six major businesses: automobile, real estate, cultural tourism, auction, flower gardening and local life, providing consumers with an integrated consumption scene of goods and services. Even buying a house, buying a car and repairing a car, which used to take a "broken leg" to complete, can now place an order online, and then complete the service at the nearest good house, Jingxuan Store and Beijing-Tokyo Car Club. In the field of home furnishing, JD.COM has also launched a brand-new model of "integration of dry support and clothing", realizing "buy in JD.COM, send in JD.COM and install in JD.COM".

This year, JD.COM 618 launched 44 new services and upgraded 38 services to create the ultimate consumer experience. Among them, JD.COM’s "assured purchase" service was upgraded again in JD.COM 618 this year, and the marked goods in the whole period of 618 were given free on-site to get back.

Trend 7: supply chain and technology: digital intelligence, full link and socialization

As a hub linking consumption and supply, JD.COM 618′ s supply chain is accelerating to upgrade in the direction of "intelligence", "full link" and "socialization", continuously optimizing the cost, efficiency and experience from the consumption end to the supply end, and making JD.COM 618 an important node of industrial upgrading.

The "digital intelligent" supply chain understands consumers better, and JD.COM JC2M intelligent manufacturing platform "Zhi" has made a series of explosive products.

Taking Linde forklift truck as an example, the company and JD.COM industrial products have created a "full-link" integrated intelligent collaborative procurement, supply and service solution. By establishing a digital connection channel with corporate customers, the company can efficiently collect customer customization needs, quickly carry out customized production and match the corresponding after-sales service.

The supply chain is becoming more open and socialized. By the end of 2020, there will be more than 1,400 cloud warehouses managed by Jingdong Logistics, and jingdong cloud Warehouse has become an important component of Jingdong Logistics’ open collaborative ecology. In April this year, Jingdong Logistics and Tencent Smart Retail launched Jingteng Yuncang, creating an innovative model from traffic to product selection to performance, further opening up the integrated supply chain capability to the society and serving ecological partners.

　　Few things touch people’s hearts as much as health. Health care is the key to people’s livelihood.

　　More new drugs are on the market, "noble drugs" are included in the medical insurance drug list, the "healthy China" action plan is deepened, and the chaos of medical beauty is rectified with heavy blows … … In 2019, these medical and health events related to people’s livelihood attracted special attention. At the end of the year, people hope to further "improve quality" and "reduce prices", and expect relevant departments to prescribe more health "prescriptions" to continuously improve people’s sense of acquisition and happiness.

　　one

　　Responding to the challenge of drug resistance, Tu Youyou team clarified the mechanism of artemisinin drugs

　　Artemisinin is a gift from traditional Chinese medicine to the world, which has contributed to the global malaria control. However, in recent years, the underlying mechanism of artemisinin in the treatment of malaria is still unclear, especially the problem of drug resistance, which is also the biggest challenge facing the global malaria control.

　　The half-life of artemisinin in human body (the time required for drug concentration to drop by half) is very short, only 1-2 hours. The course of clinical recommended artemisinin combination therapy is 3 days, and the truly efficient insecticidal window of artemisinin is only limited to 4-8 hours. However, the existing drug-resistant insect strains make full use of the short half-life of artemisinin, change their life cycle or temporarily enter a dormant state to avoid the sensitive insecticidal period. At the same time, plasmodium can also produce obvious resistance to the auxiliary drug "antimalarial formula" in artemisinin combination therapy, which makes artemisinin combination therapy "ineffective".

　　On April 24th, Tu Youyou’s team published an article online in the top international medical journal "New England Journal of Medicine", saying that the recently clarified mechanism of artemisinin drugs shows that they are precursors activated by iron or heme. Iron and heme are by-products of hemoglobin digestion, reaching the highest concentration at the mature stage of plasmodium trophozoite. Once artemisinin drugs are activated, many protein and heme of parasites will be alkylated. Alkylation of heme can also inhibit the detoxification of heme. "It is speculated that the mutation of a single protein target is unlikely to cause drug resistance, which may also explain why artemisinin drugs are still effective after decades of widespread use." Wang Jigang, a member of Tu Youyou’s team and a researcher at Artemisinin Research Center of Chinese Academy of Traditional Chinese Medicine, said.

　　In this regard, the team proposed a new treatment response plan: First, appropriately extend the medication time; The second is to replace the adjuvant drugs that have developed resistance in artemisinin combination therapy.

　　2

　　Can the "white list" of medical beauty be cured?

　　Non-medical beauty places are engaged in medical beauty treatment, the practice of doctors with informal training, and the use of unqualified medical beauty products … … In recent years, the "three non-"chaos exposed by the media has repeatedly been criticized by the society.

　　On June 18th, the National Health and Wellness Committee indicated that China Plastic Surgery Association was studying and formulating a credit evaluation management system, and it was planned to conduct credit evaluation of beauty medical institutions in some areas on a pilot basis. "The data of hardware conditions and facilities, annual inspection and doctor qualification of medical beauty institutions will be connected with the existing credit system, and a medical beauty institution &lsquo will be established in the future; White list ’ , objectively present to the people ‘ White list ’ The situation of the organization. " Cao Dequan, deputy secretary-general of China Plastic Surgery Association and director of the evaluation office, said that at that time, the public can search for information on the special website.

　　Hu Jieren, an associate professor at Tongji University Law School, said that the system itself is highly scientific and operable. It can learn from the existing credit evaluation model, listen to social voices, list the characteristics of dishonesty, and ensure fair and strict punishment. At the same time, in addition to credit evaluation and other mechanisms, the governance of medical beauty chaos requires multi-dimensional efforts and the participation of the whole society. For example, the regulatory authorities should take the initiative and increase penalties.

　　three

　　The Healthy China Action Plan is issued. Everyone is the first person responsible for his own health.

　　In July, the "Healthy China Action Promotion Committee" established in the State Council released "Healthy China Action (2019— 2030), giving authoritative guidance on what to do, how to do it and who will take the lead in healthy China.

　　"Everyone is the first responsible person for his own health." Wang Xiaoning, director of the Institute of Geriatrics of the General Hospital of the People’s Liberation Army and secretary-general of the China Association for Science and Technology’s life science association, particularly agreed with this point in the document. He explained that WHO has already concluded that in the promotion and maintenance of national health, the contribution of medical care is less than 10%, which mainly depends on people’s lifestyle and living environment. Wang Xiaoning said: "It turned out that ‘ Grip ’ The focus is on the 10% part, and now it is necessary to put ‘ Grip ’ Put it in 90%, that is, people’s lifestyle and living environment. "

　　Experts say that it is not enough for doctors and health departments to embrace health. Cardiovascular and cerebrovascular diseases are the first cause of death among Chinese residents, "Healthy China Action (2019— In 2030), it is mentioned that the goal of healthy China will reduce the premature mortality rate of major chronic diseases from 18.5% in 2015 to no more than 15.9% in 2022. Yang Jingang, an associate professor at Fuwai Hospital of China Academy of Medical Sciences, believes that the goal can only be achieved by mobilizing social forces, and the organizational model of "Patriotic Health Campaign" can be used for reference. Only by linking disease prevention and control indicators with the performance and responsibility of district leaders can we coordinate all resources and really play a role.

　　four

　　Major projects support the initial establishment of a drug innovation technology system in China.

　　In view of the difficulties and expensive medical treatment for ordinary people, and the heavy dependence on imports of high-end medical equipment and drugs, as early as 2008, China deployed and implemented the major scientific and technological project of "major new drug creation" (hereinafter referred to as the new drug creation project).

　　"With the special support of new drug creation, a total of 14 Class 1 new drugs were approved after February 2017, showing a blowout growth." At the end of July, at the conference of "Creation of Major New Drugs", Chen Kaixian, deputy chief engineer of special technology and academician of Chinese Academy of Sciences, introduced that in the past two years, new progress has been made in the research and development of special varieties, and six Class I new drugs have been approved for the treatment of malignant tumors. In addition, the achievements of the special project of new drug creation include the first domestic and the second long-acting anti-AIDS drug, the new anti-infective drug, Clindamycin, which is independently developed, and the world’s first aromatic hydrocarbon receptor modulator and non-hormonal small molecule chemical drug, Benvimod & HELIP, which has therapeutic effect on psoriasis. …

　　The national drug innovation technology system has been initially established in the special project of new drug creation, and a series of technical platforms have been laid out; Initially, a grid-based innovation system with scientific research institutes and universities as the main source innovation, enterprises as the main technology innovation, the close integration of the upper, middle and lower reaches and the deep integration of politics and Industry-University-Research has been established, and the ability of independent innovation has been significantly improved.

　　five

　　The paper has sparked a heated discussion on whether "Aristolochic acid-induced liver cancer" is a real hammer or a misunderstanding.

　　In August, aristolochic acid once again became the focus. Han Zeguang, a professor at systems biomedicine Research Institute of Shanghai Jiaotong University, published a paper in the international journal Hepatology in the field of liver diseases, which was emphasized by many media as "aristolochic acid has caused liver cancer to have a real hammer". This study revealed that aristolochic acid alone can cause liver cancer in mice in a dose-dependent manner, that is, the greater the dose of aristolochic acid, the shorter the time to cause liver cancer and the larger the tumor. When aristolochic acid is combined with carbon tetrachloride, it can induce liver cancer in mice in a dose-dependent manner, including hepatocellular carcinoma and hepatocellular carcinoma and intrahepatic cholangiocarcinoma.

　　However, Luan Yang, a researcher at Shanghai Jiaotong University School of Medicine, and others believe that the data obtained by Han Zeguang’s team under certain experimental conditions are not enough to draw the conclusion that aristolochic acid causes liver cancer, and it cannot be called a "real hammer". "Specific experimental conditions" means that the experimental object is young mice and carbon tetrachloride liver injury model.

　　Some experts also said that some media interpreted the latest experiment of Han Zeguang’s team as "solid hammer" evidence that aristolochic acid is the main cause of liver cancer in China, but it should be noted that the original literature is in young mice (equivalent to 1-mdash; 2-year-old baby) and carbon tetrachloride liver injury model, which is different from the clinical occurrence of liver cancer, and many independent studies have been published in the world for many years, but no results of liver cancer caused by aristolochic acid have been made in adult mice, so it is too early to think that aristolochic acid is the main cause of liver cancer in China.

　　six

　　The original research drug went to sea for the first time, and the national research anticancer drug was approved for listing in the United States.

　　A movie, Dying to Survive, made anticancer drugs attract public attention. Subsequently, zero tariffs on imported anticancer drugs and negotiations on anticancer drugs have also become hot spots of public concern.

　　On September 23rd, the National Health and Wellness Commission and other 10 departments jointly issued the Healthy China Action — — Cancer prevention and treatment implementation plan (2019— In 2022) (hereinafter referred to as the "Program"), the "Program" pointed out that a set of "combination boxing" will be made by unblocking the temporary import channels of anticancer drugs that are urgently needed in clinic, promoting the substitution of generic drugs, and incorporating them into medical insurance, so as to improve the accessibility of anticancer drugs and enable ordinary people to buy, afford and use anticancer drugs in China.

　　The "Proposal" clearly stipulates that the zero tariff on imported drugs should be promoted, and various links such as R&D, production, procurement, import and use should be fundamentally straightened out, and the price of anticancer drugs will continue to decline, further promoting the simultaneous listing of new overseas drugs in China and avoiding the "foreign moon and domestic circle" caused by the difficulty in obtaining anticancer drugs.

　　Nowadays, the situation of "only getting in but not getting out" of original anticancer drugs has been broken. On November 14th, zanubrutinib, a BTK inhibitor developed by Baekje Shenzhou Company, was approved by the US Food and Drug Administration (FDA) for the treatment of adult patients with mantle cell lymphoma who had received at least one therapy before. At this point, "the drug became the first new anti-cancer drug independently developed by local enterprises in China and approved for listing by the FDA, realizing the new drug originally developed by China ‘ Zero breakthrough ’ 。” Dr Wu Xiaobin, general manager and president of Baekje Shenzhou China, said.

　　seven

　　Supervision is imminent. E-cigarettes are as harmful as traditional cigarettes.

　　Some businesses advocate that e-cigarettes are less harmful to human body and can help smokers quit smoking. Self-adjusting taste, cleanliness and environmental protection, and convenient use have all become eye-catching labels of e-cigarettes.

　　"Generally speaking, e-cigarettes will highlight the characteristics of high technology content and trendy fashion in product performance and ingredients. However, the ingredients of e-cigarettes are nothing more than nicotine, water, spices, propylene glycol and glycerol. As for the principle, it is even simpler, just an electronic evaporation, and there is no technology content at all." Zhang Zhigang, a senior engineer of China Environmental Behavior Law Society, said.

　　More seriously, consumers don’t know that under normal use conditions, the concentrations of some metals (including lead, chromium and nickel) and formaldehyde in some e-cigarette aerosols are equal to or higher than those in traditional cigarettes, and these harmful substances are even higher than the content of second-hand smoke produced by traditional cigarettes. In addition, e-cigarettes will also produce some toxic substances that are not found in traditional cigarette smoke, such as glyoxal, which is flammable, toxic and irritating, and its vapor or fog will stimulate eyes, mucous membranes and upper respiratory tract.

　　With the United States, Japan, India and other countries banning e-cigarettes to varying degrees, the voice that China should legislate and supervise e-cigarettes as soon as possible is getting louder and louder. Hu Qingyuan, director of the National Tobacco Quality Supervision and Inspection Center, said: "Fortunately, we have already started to act." On November 1, the State Tobacco Monopoly Bureau and the State Administration of Market Supervision jointly issued the Notice on Further Protecting Minors from E-cigarettes, urging enterprises or individuals that produce and sell e-cigarettes to withdraw their e-cigarette advertisements published through the Internet, and the supervision of e-cigarettes is becoming increasingly strict.

　　eight

　　Can cerebral palsy be cured? "Needle-sealing therapy" triggered a normative discussion on new therapy.

　　Cerebral palsy is recognized by the medical community as incurable. However, the media reported that the Third Affiliated Hospital of Zhengzhou University (hereinafter referred to as the Third Affiliated Hospital of Zhengzhou University) adopted "needle sealing therapy" for children with cerebral palsy (the full name is "point plus acupoint drug injection therapy"), and the hospital claimed to evaluate 381 children. The results showed that 190 cases, that is, nearly half, were normalized.

　　On October 21st, an article questioned the "needle sealing therapy" invented by Wan Guolan, the founder and honorary director of the Children’s Rehabilitation Department of the Third Affiliated Hospital of Zhengda, and the "needle sealing therapy" was pushed to the forefront. Sun Yong ‘an, chief physician of the Department of Neurology, Peking University First Hospital, said that "needle sealing therapy" is more of a gimmick, and even if it is effective, its effect is limited. Nerve injury is generally caused by congenital development or acquired injury. If it is cerebral palsy caused by poor nerve development in the embryo, even if there is some growth compensation, it is still difficult to completely cure it.

　　Cerebral palsy is difficult to treat, and there is no standard single treatment. Some experts said that we should not arbitrarily think that all self-created therapies are ineffective. Because medicine is a practical subject, it is advancing through constant exploration and trial, and some new therapies really need to break through the routine. However, the technology applied in clinic should be universally recognized and supported by evidence-based medicine. To carry out a clinical trial, first of all, the institutions involved and the researchers involved in the trial must have the qualifications to carry out clinical research; Second, it is necessary to carry out strict registration and filing, and strictly design the test plan, demonstration and modification; Third, it should be recognized by clinical trial management institutions and ethics committees; Fourth, the subjects should have the full right to know, the experimenter should ensure the safety of the subjects, and the subjects have the right to withdraw at any time during the treatment. As for the efficacy of the new therapy, it also needs a large sample of randomized double-blind controlled studies to verify it.

　　nine

　　At the dawn of treatment, "small molecular glue" can devour the pathogenic protein of Huntington’s disease

　　Involuntary dance-like movements, cognitive impairment and mental abnormality … … Huntington’s disease is one of the four major neurodegenerative diseases. Because the biochemical activity of the mutant Huntington’s protein (mHTT) causing the disease is unknown, it can’t be targeted. The traditional method of blocking the activity of the pathogenic protein by blocking agents is not suitable for the treatment of the disease.

　　At the end of October, researchers from Fudan University published their achievements in Nature, and found a "small molecular glue" that "devours" Huntington’s disease-causing protein through screening based on compound chips and cutting-edge optical methods, which is expected to bring new dawn to the clinical treatment of Huntington’s disease.

　　In the study, the team focused on controlling autophagy, an intracellular protein degradation pathway, to effectively reduce the level of mutant Huntington protein. In order to solve the problem of "self-injury", the team imagined to invent a kind of "small molecule glue", which can aim directly at the bull’s-eye, firmly stick LC3 and pathogenic protein (or other pathogenic substances) together, and then wrap the pathogenic protein into autophagy bodies for degradation. After screening, purification and a series of cell experiments, the research team obtained four kinds of "small molecular glues" that can bind LC3 and mutant Huntington protein.

　　According to team member Lu Bojun, at least two of these four compounds can cross the blood-brain barrier and directly reduce the level of mutant Huntington protein in the cerebral cortex and striatum of Huntington’s disease mice through low-dose intraperitoneal administration, without affecting the level of wild-type Huntington protein in brain tissue, and also improve the disease-related phenotype, which provides a breakthrough point for the development of oral or injection drugs for Huntington’s disease, and is expected to be applied to motor coordination disorders, facial twitching and muscle spasms.

　　10

　　"Aristocratic Drugs" Self-devalued Medical Insurance Drug List Negotiation to Reduce Patients’ Burden

　　Only when good drugs enter medical insurance can people finally get benefits.

　　In December, the National Health Insurance Bureau released the National Drug List of Basic Medical Insurance, Work Injury Insurance and Maternity Insurance in 2019 (hereinafter referred to as the Drug List). The results showed that 97 of the 150 negotiated drugs were successfully negotiated, and the average price dropped by 60.7%. This is also the largest since the establishment of the medical insurance system in China, with remarkable results.

　　During the negotiation, the National Medical Insurance Bureau spared no effort in bargaining. Take the shortlisted hepatitis C drugs as an example, four companies directly measure the quotation on the spot, and the quotation of each drug should be accurate to two decimal places. There are two quotations in total. If both of them fail to reach the psychological price of the medical insurance bureau, or exceed 15% of the medical insurance payment standard, they will be directly out. In the end, Ledipaviso fosbuvir tablets from Gilead Scientific Company, fosbuvir patavir and Elba Wegera Rive tablets from Merck were selected with an average decrease of 85%.

　　Xiong Xianjun, director of the Department of Medicine Management of the National Health Insurance Bureau, said that the significant reduction in drug costs is one of the results of this negotiation. By giving play to the role of the medical insurance department as a "strategic buyer", the drug costs will be greatly reduced by changing the price. A number of world-renowned "noble drugs" have been marked with "civilian prices", and imported drugs have basically given the lowest price in the world. It is conservatively estimated that through negotiation of price reduction and medical insurance reimbursement, the personal burden level of patients will be reduced to less than 20%, and individual drugs will be reduced to less than 5%.

The 2023 World Artificial Intelligence Conference was held in Shanghai from July 6 to 8. The main exhibition of the 50,000-square-meter Expo covers four sections: core technology, intelligent terminal, application empowerment and cutting-edge technology, involving large models, chips, robots, intelligent driving and other fields. There are over 400 exhibitors, over 50 excellent start-ups, and more than 30 new products are exhibited for the first time. The number of exhibitors and exhibition area are the highest in history.

Layout of the new track of the future industry, large models have appeared.

Enter the key words of the work in the computer, such as "thick painting, illustration, girl, cuteness", and then choose different painting styles, and you can generate a beautiful painting in just over ten seconds. During this World Artificial Intelligence Conference, the reporter experienced the first AI painting experience activity launched by Netease Fuxi, Shanghai Communist Youth League Committee and Donghao Lansheng. This technology relies on the picture generation model developed by Netease Fuxi-"Danqing", which is also a 100% domestic model.

Picture generation model "Danqing", courtesy of Netease Fuxi.

According to the staff, the large model is trained based on native Chinese corpus data and Netease’s own high-quality picture data. After strict text and picture review, the model has good Chinese understanding ability while ensuring data source compliance and generated content compliance, and the works created can better meet Chinese aesthetics. In addition, the big model also supports users to give multiple rounds of modification suggestions across multi-modes such as words and pictures until satisfactory picture effects are generated.

"The big model is not a fireworks show, but an advanced productive force. This wave of AGI revolution is a brand-new meta-revolution. The big model is of great significance for industrial development. With the big model, enterprises have ushered in a new opportunity and realized an’ end-to-end’ value realization. " On the 7th, Xiao Yanghua, director of Shanghai Key Laboratory of Data Science and professor of Fudan University, co-hosted the theme forum "The Infinite Charm of AI Generation and Vertical Language Model" in Shanghai Pudong New Area Youth Federation, Daguan Data and Youkede.

The "Cao Zhi" big model of philosophical data was released. View data for the picture

At the forum, Chen Yunwen, Chairman and CEO of Daguan Data, officially released the "Cao Zhi" model of Daguan Data. As a vertically specialized large-scale domestic language model, this large model has the characteristics of long text, verticalization and multilingual. By connecting multiple models and knowledge maps in parallel, it supports the functions of automatic writing and multilingual translation of long texts in multiple languages, and enables all-round scenarios such as long document writing, machine translation, semantic analysis review, knowledge question and answer, text-to-SQL, etc., and can be deeply optimized and customized according to the needs of copywriting in different industries and fields. Whether in finance, government affairs or industry, Cao Zhida model can provide accurate and effective solutions for copywriting.

As a domestic strategic partner of Cao Zhi’s big model, UCloud’s AIGC computing base also made a wonderful appearance. Benjurry Ben, Chairman and CEO of UCloud, delivered a keynote speech on "Neutral and Secure Cloud Computing Helps the Development of Big Model", introducing its technical products, engineering capabilities and ecological construction in the field of AIGC.

The panoramic view of Youke AIGC solution made a wonderful appearance. You ke de gong tu

Youke’s AIGC solution panorama, which was unveiled this time, has launched a series of products and solutions covering data centers, computing platforms, management platforms, network services, application services and ecological interfaces through profound technical accumulation and comprehensive system engineering capabilities. The open, secure and customized AIGC solution allows customers to utilize existing server resources, and enjoy the flexible expansion of public cloud conveniently, so as to reduce costs and increase efficiency at the IT level. And through the data center hosting area, it can provide users with exclusive cabinets, servers, networks and storage resources that are completely physically isolated. Combined with complete security schemes and expert services, it ensures the smooth operation of users’ large models.

Benjurry Ben said that he will continue to explore the greater development prospects and broader development space of AIGC with the "Cao Zhi" big language model through the neutral and safe computing base. We will jointly improve the ability of enterprises to apply large models in privatization and promote the process of landing large models at the enterprise level.

Panoramic insight report of exhibitors at the 2023 World Artificial Intelligence Conference released by Digital Library Technology. Digital library technology for the picture

At this World Artificial Intelligence Conference, Database Technology released a brand-new conceptual product atlas-"ISTARI". The on-site staff introduced to the reporter that "istari" is a conceptual product that integrates UPG and large model exhibited at the conference of Digital Library Technology, and it is a new generation of industrial panoramic map platform that can present dialogue and interaction. Based on this small dialogue window, the data dimensions of industries and products and related companies are at your fingertips.

It is reported that the digital government solution is the main push of database technology, in which the industrial monitoring brain platform can carry out real-time monitoring and comparative analysis on industrial scale, industrial environment and other aspects, and through the multi-chain integration of supply chain, innovation chain, policy chain and talent chain, statistics and analysis of relevant upstream and downstream entities, policy orientation, etc., the business environment and investment and financing data can be integrated, and industrial ecological projection can be realized on the big screen through data visualization display. Assist policy implementation and project landing. At the same time, through the full-scene industrial map capability and big data mining analysis means, we will build a data base for investment promotion, empower nearly 50 investment promotion methods such as industrial chain investment promotion, enhance the full-scene data service capability of investment promotion, and vigorously promote the high-quality development of the industry.

Leo Liu, founder and CEO of Digital Database Technology, said at the "Smart Data Smart Way-Data Intelligence Forum" that since the establishment of industrial chain system by Digital Database Technology, enterprises have continuously upgraded iterative data products to better build industrial chain system and serve the real economy, and launched ——UPG(Universal Product Graph), an upgraded data product based on SAM industrial chain system. In the future, based on UPG unified product atlas system, all kinds of relationship lines will be further expanded, and finally the digital transformation will be effectively empowered.

Robot +AI: Towards a new era of embodied intelligence

At present, the industry generally believes that the next wave of artificial intelligence is embodied intelligence. As the carrier of artificial intelligence entering the physical world, embodied intelligence combines artificial intelligence technology with robot entities, giving the "brain" a body that can be controlled, perceived, interacted and acted, and bringing great convenience and benefits as an important partner and assistant of human beings.

At the opening ceremony of this World Artificial Intelligence Conference, a universal humanoid robot GR-1 released by Fu Liye Intelligent in the first show of major innovations has aroused widespread concern in the industry. The robot is 1.65 meters tall, weighs 55 kilograms, has 40 degrees of freedom, the maximum peak torque of joint module can reach 300NM, the walking speed can reach 5KM/h, and the load is 50 kilograms.

According to the staff, this robot has a highly bionic trunk configuration, anthropomorphic motion control, fast walking, agile obstacle avoidance, steady uphill and downhill, anti-impact interference and other motion functions, combined with cognitive intelligence, can cooperate with people to complete actions, and has great potential in many application scenarios such as industry, rehabilitation, home, scientific research and so on.

Fu Liye’s intelligent GR-1 universal humanoid robot debut. Fu Liye Intelligent Photo courtesy

As the next generation ontology of AI with body intelligence, humanoid robots are expected to lead AI into the "era of body intelligence", and will also promote the development of special robots to general robots. Gu Jie, founder of Fu Liye Intelligent, believes that, just like the development trend from desktop computers to personal computers to mobile phones, universal humanoid robots will gradually become the mainstream of the industry in the future. At present, the hardware foundation of universal humanoid robot is basically laid, and the application wave driven by large model is coming.

Unmanned loading robot. Photo courtesy of Netease Fuxi

"In the field of construction machinery, this unmanned loading robot can quickly adapt to different models, and can automatically perform actions such as moving, accelerating and decelerating, shoveling and unloading. The full bucket rate of shoveling operation is over 95%, and the residual rate of unloading hopper is below 5%. The shoveling efficiency is close to that of the master." In the exhibition area of artificial intelligence, the staff mentioned that this unmanned robot was jointly developed by Netease Fuxi and China Construction Eighth Bureau. It is a highly intelligent and fully automated main construction machinery based on the scene of mixing station.

"The concrete mixing station is the basic supply of the construction site, and it needs 24 hours of uninterrupted operation, and a lot of dust and particles will be generated during the operation. Therefore, mixing stations often face the problem of difficulty in recruiting workers. " The staff said that taking the mixing station with two machines and 180 units as an example, the standard configuration is 2 loaders +4 drivers. However, after the replacement of the unmanned loader, only one driver is needed to handle 1% of the special conditions, and the other 99% of the cases can realize the unmanned automatic feeding operation.

At present, the unmanned loading robot has been applied to the intelligent concrete mixing station of Hutong Railway, and batch delivery will be realized this year, so that construction workers can bid farewell to the dangerous working environment and achieve high safety and high quality work.

Accelerate the innovative application of AI in the industry and help achieve the goal of "double carbon"

How can artificial intelligence and big data technology help reduce carbon and promote high-quality development?

Q-Truck, 2023WAIC "Treasure of Town Hall". People’s Daily reporter Ge Junjun photo

Q-Truck, a driverless commercial vehicle with intelligent power exchange displayed by Xijing Technology, is the "treasure of town hall" in 2023WAIC. The staff introduced: "In terms of carbon reduction, after calculation, Q-Truck completely uses green electricity in actual production and operation scenarios, and bicycles can reduce carbon dioxide emissions by 50 tons per year, which is equivalent to planting 4,545 trees per year by bicycles, and the annual planting area of bicycles is 113,400 square meters."

Q-Tractor。 Photo courtesy of Xijing Technology

This year, Xijing Technology’s new energy unmanned tractor Q-Tractor was launched in the world in 2023WAIC. This product can be adapted to multiple scenes such as airports, factories and logistics centers, with deeper scene interconnection, more humane driving experience, highly derivative application scenarios and higher-order automatic driving, and can be used in logistics transportation fields such as small cargo transportation and luggage traction. The maximum load of Q-Tractor is 40 tons, and it can realize all-weather transportation for 7×24 hours, which is more stable, smooth and convenient, with "zero pollution and no emission". The relevant person in charge of Xijing Technology expressed the hope that with the help of WAIC, we can help more users to effectively reduce the cost of global production factors and create a green, intelligent and resilient global smart logistics.

"Smart Help Double Carbon, Traces to Follow" 2023 Smart Trend Forum. Photo courtesy of Schneider Electric

At present, the digital economy has become an important pillar of national economic growth. How to accelerate the integration of digital and real industries and move towards green and low carbon with key technologies has become an important issue to achieve high-quality development. Zhang Lei, vice president of Schneider Electric and head of digital service business in China, said at the 2023 Smart Trend Forum: "Artificial intelligence technology is the driving force to promote the leap-forward development of science and technology, industrial optimization and upgrading, and the overall jump in productivity. However, under the general trend of digital integration, the key to the potential of new technologies such as AI lies in their industrialization and large-scale application."

In order to accelerate the innovative application of AI in the industry, Schneider Electric recently set up an AI innovation laboratory in Beijing, and the AI innovation laboratory in Shanghai will soon be established.

Zhang Lei said that in addition to advanced models and algorithms, the key value of AI technology lies in combining practical application scenarios to meet industrial needs. To this end, Schneider Electric is accelerating the creation of an incubator for AI innovation applications. Its AI Innovation Lab is committed to exploring the application innovation of "entity industry+technology ecology +AI" and exploring the application of AI technology in asset and process optimization, infrastructure management, demand management and new energy management, empowering the digitalization and sustainable development of major industries.

"Future car" is about to sail to the "fast lane" of commercialization.

Starting from Shentao Road, Jinqiao Economic and Technological Development Zone, Shanghai, turn left to Jianqiao Road … The whole journey is 2.8 kilometers, which takes about 15 minutes. On July 8, during the 2023 World Artificial Intelligence Conference, the "Driver-free Intelligent Networked Car Show" in Shanghai Jinqiao Demonstration Zone was opening up the autopilot experience to the global audience.

This is the first time that the first batch of enterprises in Pudong New Area have obtained the "driver-free test license" to test their vehicles on the road. AutoX Antu and Neolithic Unmanned Vehicles became the first batch of "unmanned vehicles" enterprises to obtain the license for road test of driverless intelligent networked vehicles issued by Pudong New Area Government.

"Every car travels an average of 80-100 kilometers every day to conduct a safe driving test in driverless mode." Jinqiao, Pudong, Shanghai’s first self-driving open demonstration application road in the central city, has a wealth of application scenarios in the central city of super-large cities and has become the best testing ground for artificial intelligence technology. Lin Tailai, vice president of AutoX, said: "We need to realize the commercialization of completely driverless taxis in large urban areas on a large scale, reduce the cost of intelligent upgrading of automobiles through large-scale mass production, and realize the sustainable development of commercialization and marketization."

"In solving the’ last mile’ with the highest cost and lowest efficiency in logistics distribution, the cost reduction ratio of each unmanned delivery vehicle can reach more than 60%." Huang Hantao, director of the government affairs department of Neolithic Academia Sinica (Shanghai) Technology Co., Ltd. said: "After receiving the notice of innovative application test, we can speed up the test in Pudong and develop three business models: unmanned retail, unmanned distribution and unmanned urban service. I believe that in the future life scene, there will be more and more unmanned equipment like Neolithic unmanned vehicles on the road. "

It has been more than two years since the outbreak of COVID-19 at the end of 2019.Sequela of COVID-19Discussions on related topics have never stopped.

"COVID-19 may cause permanent damage to male sexual function?"

"terror! More than 200 kinds of sequelae of COVID-19 are difficult to cure for life! "

"COVID-19 after cure, sequela emerge in large numbers! Experts uncover the cruel truth … "

Since February this year, with the spread of Omicron mutant and its subfamily, the epidemic has rebounded and spread on a small scale in many cities in China. The constant variation of COVID-19 virus has always kept the "sequela of COVID-19" in the fog. However, the growing number of recovered people in COVID-19 has rapidly fermented the fear of COVID-19’s sequela. We can see this fear from the emotional distribution of public opinion about COVID-19’s sequela on social media.

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Obviously,Fear occupies the absolute majority of public opinion.But it seems that some people are slowly accepting the sequela of COVID-19. This may be related to the difference in toxicity between Omicron strain and previous strains. However, people’s negative emotions still dominate the mystery of COVID-19’s sequela.

Is the sequela of COVID-19 really terrible?The medical community can’t give an exact answer at present, especially in the context of Covid-19’s continuous evolution. However, infectious diseases have always been the main diseases threatening human health, and even to some extent, infectious diseases and human beings have jointly constructed social life and history. Perhaps from the history of human infectious diseases for thousands of years, we can find some traces of answers.

In history, have humans ever defeated infectious diseases and their sequelae?

Infectious diseases break out at different stages of human development, andThe human struggle against the sequelae of infectious diseases is always in a continuous state.. This persistence lies not only in the fact that its sequelae will still have a long-term impact on the recovered after the epidemic of infectious diseases has been controlled, but also in the fact that it takes a long time for human beings to recognize the sequelae caused by these widespread infectious diseases.

Not every infectious disease will cause sequelae, butEvery disease that may leave sequelae for the recovered has left an indelible mark on human history.. Looking back at the development history of infectious diseases that left sequela problems, it is not difficult to find the power of these diseases.

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For thousands of years,Only smallpox is the only truly eradicated infectious disease in human history.While other infectious diseases are still dormant in every corner of the earth. Before the birth of modern science, human beings didn’t fully understand viruses and bacteria, and there were still many puzzles about what infectious diseases were, how they occurred and how to effectively prevent, deal with and contain them, especially for the sequelae of infectious diseases.

Overcoming the sequela of COVID-19, it seems, is not a short process.

How long does it take to correctly understand a sequela?

In the face of the sequelae of infectious diseases, human beings, like other temporarily unknown things, seek answers from practical experience and try to establish their understanding of the sequelae of infectious diseases.

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As the experience of fighting SARS, hepatitis B and influenza shows,The study of sequela is based on the epidemic of infectious diseases, and the long-term sequela makes the study of sequela lag behind the occurrence of epidemic of infectious diseases for a long time.The outbreak of hepatitis B in China was from 1970 to 1992, but the number of related studies on the sequelae of hepatitis B reached its peak in the 21st century.

At the same time, the pathogens of some infectious diseases are constantly changing and updating.It seems that the sequela of infectious diseases and human beings have also become an endless tug-of-war.Influenza virus has undergone many mutations during its epidemic thousands of years. For example, the 1918 influenza virus, known as the "mother of pandemic", has been studied, and almost all influenza A (except avian influenza virus, such as H5N1 and H7N7) in the world since then are its descendants. The research on the sequela of influenza has been going on for centuries, but so far it has not been able to give a definite conclusion.

A large sample study of sequelae of COVID-19 also needs a long time span. At present, there have been achievements in the research of COVID-19’s sequelae in the medical field, and the research object is mainly COVID-19 patients in 2020, and there is a great difference between the infected strains of COVID-19 patients in 2020 and the popular Omicron variant.The sequela of COVID-19 is still an unpredictable variable.

What are the consequences of the unknown sequelae?

Academic research itself lags behind the outbreak of infectious diseases, and human beings are often in the blank or limited cognition of diseases and their sequelae for a long time.Faced with the unknown, out of worry and fear, people may avoid patients with diseases, and even breed group malice against patients.

Just as people are sensitive and uneasy about "COVID-19" nowadays, from the end of 20th century to the beginning of 21st century, Chinese in this period fell into a panic about "Hepatitis B".

Hepatitis B virus carriersThere is a certain probability of complications such as hepatocellular carcinoma, chronic active hepatitis with or without cirrhosis. The serious illness made people nervous for a while, and also made hepatitis B carriers bear numerous social pressures at that time. The word "hepatitis B discrimination" also comes from this.

"hepatitis b discrimination"It refers to giving different, often unreasonable and unequal treatment to hepatitis B virus carriers outside the conditions stipulated by law. The wrong understanding of hepatitis B is the root of social prejudice and discrimination. At the same time, there are many patients with hepatitis B in China, and the social discrimination against hepatitis B patients and hepatitis B virus carriers is more serious.

China’s laws and regulations related to hepatitis B are gradually improved and perfected in the exploration of hepatitis B cognition.

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At the end of 1980s, the research on hepatitis B in the medical field was not clear, and hepatitis B was mistaken for being highly contagious, and many rights and interests of hepatitis B carriers were restricted. Since the 21st century, with the deepening understanding of hepatitis B, especially the frequent occurrence of cases of discrimination against hepatitis B, the society and the country have gradually paid attention to this issue. According to the actual situation, relevant departments have promulgated and implemented a number of laws and regulations to solve the problems.

In 2010, atNotice on Further Standardizing the Physical Examination Items for Admission and Employment and Safeguarding the Admission and Employment Rights of HBsAg CarriersAfter the introduction, local governments and relevant departments responded in succession to protect the enrollment and employment rights of HBsAg carriers. It was also in this year that the number of laws and regulations related to hepatitis B reached its peak, and then it became more and more stable.

From the beginning of "talking about the color change of hepatitis B" to the later protection of rights, it is inseparable from the gradual establishment of objective cognition by all sectors of society and joint efforts to eliminate discrimination.Getting rid of people’s sensitivity and anxiety about "COVID-19" may also be inseparable from this process.

At present, more than 550 million COVID-19 patients have been confirmed in the world, and nearly 530 million people have been cured. The increasingly prominent sequela problem in COVID-19 has brought double challenges to academic research and policy planning. The sequela of COVID-19 needs the public’s attention and understanding, and the implementation of intervention measures by all sectors of society. The academic research of COVID-19’s sequela is not clear, and the policy planning of COVID-19’s sequela in China is still in the exploratory stage.

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At present, the country has explored COVID-19’s sequela policy from the aspects of advice, rehabilitation platform and economic subsidies.Some places have also begun to build rehabilitation hospitals in Kangding. For example, Suzhou City has designated the People’s Hospital of Suzhou Taihu National Tourism Resort as the designated rehabilitation hospital in COVID-19. It is imperative for the state to improve relevant measures as soon as possible to protect the rights of patients with sequelae of COVID-19 in the post-epidemic era. Whether it is necessary to further implement assistance to patients through legislation and other measures like hepatitis B remains to be discussed.It still needs some distance to get rid of people’s sensitivity and anxiety about "COVID-19".

How far are we from getting rid of the anxiety of "COVID-19 Sequela"?

If we want to know how far it is from getting rid of the anxiety of "COVID-19 sequela", we must first know what caused people’s anxiety about COVID-19 sequela. From people’s discussion on COVID-19’s sequela, we can find some key points.

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The anxiety about COVID-19’s sequela may be related to the influence of COVID-19’s sequela on the body.Symptoms of COVID-19’s sequela have attracted much attention. Besides symptoms, nouns such as fatigue, hepatitis, taste and adjectives such as fatigue also appear frequently. The academic circles can’t determine exactly what the "symptoms" of COVID-19’s sequela are, but in the discussion of COVID-19’s sequela, the impression of "COVID-19’s sequela" has gradually formed.

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Although these impressions may not be supported by scientific evidence, they will inevitably cause some panic.The influence of COVID-19’s sequela on mental state is often discussed, and adjectives such as "anxiety", "fear" and "depression" appear many times. Women, the elderly, etc. are also mentioned as the possible susceptible groups of sequelae of COVID-19.

Apart from paying attention to COVID-19’s sequela symptoms and personal emotional state,The anxiety about COVID-19’s sequela may also be related to the influence of COVID-19’s sequela on social life.In the phrase "life", keywords such as "dismissal" and "work" have also been discussed to some extent.

On May 29th, 2022, a blogger "I’m a little monster" who returned to COVID-19 for rehabilitation claimed that the organization where he worked as a Russian teacher asked to leave after learning that he had been infected with COVID-19. She said that she had done 50 or 60 nucleic acids, and all of them were negative. She also hoped that the society would be more tolerant and understanding to the recovered people in COVID-19.

Some people understand the reason why she was fired: "Because this disease will recur endlessly, and once you recover, everyone who comes into contact with you will become close or sub-close, and they may all face isolation … But please believe that everyone is kind, not discriminating, but afraid of separation and life and work stoppage." Some people also talk about similar experiences or concerns with bloggers. "When the cabin came back, people in the same building saw me close the door with a thief." "The little monster is still a hot self-media on the Internet. What about others? What should other ordinary people infected with COVID-19 do if they encounter such a thing?"

In fact, this blogger’s situation is not a case.A report published by The Lancet found that some people failed to return to their pre-infection work status or work after COVID-19 was infected, butThe reasons for losing one’s job are directly or indirectly related to COVID-19’s sequelae.

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How far are we from getting rid of the anxiety of "COVID-19 sequela"?

What effect COVID-19’s sequela will have on the health of COVID-19’s recovered people is an unpredictable variable, which needs to be verified by the medical community in time. If we want to form a reasonable attitude of society towards COVID-19’s rehabilitated people, we need all sectors of society to work hard to eliminate inequality and irrationality.

Mark Twain once said, "History will not repeat itself, but just like the rhyme of the article, similar events will happen again." The distance between us and getting rid of the anxiety of "COVID-19 sequela" is the same as that between human beings and other infectious disease sequela panic in the past.

Is the sequela of COVID-19 really terrible? History will give the answer.

References:

1. Shen Guoqiang, Ren Huiyan, Zhou Long, Wang Zhangye, Yan Xiaoyi. Study on the response policy and evaluation system of novel coronavirus epidemic [J]. Science and Technology Herald, 2021,39(05):87-98.

2. Zhang Wenhong, "Zhang Wenhong said pollution", CITIC Publishing House

3. World Health Organization https://www.who.int/zh/

4. Law on the Prevention and Control of Infectious Diseases (until 2021)

5.Lixue H，Qun Y，Xiaoying G,etal.1-year outcomes in hospital survivors with COVID-19:a longitudinal cohort study[J].Lancet(London,England).398(10302):747-758.

6. Emerging Infectious Diseases, an academic journal of CDC in the United States, January 2006, Volume 12, No.1, with the title of 1918 Influenza: Mother of All Pandemic Diseases.

7. People’s Network

http://www.people.com.cn/wsjk/wsjk11/112/pvw894121.htm

8.https://baijiahao.baidu.com/s? id=1725511321170854939&wfr=spider&for=pc

https://news.sina.com.cn/s/2020-03-15/doc-iimxyqwa0649265.shtml

https://xueqiu.com/9936619624/140976983

Author team:Dong Jieyun Lin Huan He Qing

Instructor:Bian Qing

Tongji University Art and Media College "Integrated Media Reporting" Course Column

Contact information of the author:

19821236527 (mobile phone)

1037002425@qq.com (mailbox)

Produced by:Tongji university college of art and media

Special feature of 1905 film network　"I can bear all this because I am not a hero … … I can be what the city needs me to be. " — —

When interviewing the director Xu Jizhou, the Beijing veteran said to us: "When I was writing this script, I just listened to the story completed by the soundtrack of The Dark Knight over and over again."

The Dark Knight.

This just corresponds to Xiaobian’s view after watching the movie: it is a movie with the taste of the Dark Knight.

After meeting Xu Jizhou’s director and the original author Remy, I felt more empathy for the difficult "chivalrous road" taken by City Lights.

[On the Eve of Dawn]

Deng Chao in City Lights

At first, many viewers were not optimistic about the remake of this work, including Xiao Bian himself.

Due to the word-of-mouth failure of the first film, many fans and book lovers have mixed attitudes towards City Lights. Fortunately, the new film is escorted by Ehan Juan, the Golden Horse winner, and Deng Chao, the Golden Goblet Awards winner, including the original author Remy, who also personally joined the script creation. The lineup is hard to refuse.

On the other hand, the series of "Psychological Crime" is different from the same type of works in that it takes the ritualized crime scene and brutal criminal methods as the first voice. Whether the film version can restore the case scale and story trend in the original work has always been a concern of fans.

The Crime Scene in City Lights

After meeting the director, we realized that the beginning of this work actually originated from Xu Jizhou’s own obsession with this novel.

According to the original author Remy’s recollection, the director decided to film "Light of the City" almost immediately after reading the novel: "At that time, he happened to be filming in Chongqing, and after knowing that the novel of" Light of the City "was going to be listed, he directly killed Chongqing Publishing Group and brought back a sample book in advance. After reading it, he was particularly excited. He came to Shenyang directly and told me that he hoped to buy the movie copyright of this novel. "

As for this persistence, the director frankly comes from a fit state of mind: "The attitude expressed in the novel was also owned by me at that stage, and the story touched me very much, so I decided to give it a try." So "City Lights" became the director’s first film work.

However, the fact is cruel, and the road to the release of criminal works in China is always particularly stumbling. The early script creation and revision of City Lights lasted for more than two years. Director Xu Jizhou and Remy, as well as Jiang Zhiqiang, the boss, have repeatedly run in on the content of the script. As the original author, Remy even advised the director to make more deletions: "I may be one of the few screenwriters who advised the director to delete his own works. However, Xu Dao really insisted on the core content, and most of the key events and details were preserved to the greatest extent in the film. "

The novel "City Light of Psychological Crime"

During this period, Remy also adapted what was not used in the script into an exotic novel — — Two Flowers, of course, is beside the point.

After the final shooting was completed, the film originally scheduled for release at the end of September experienced the storm of extension and deletion, and it was delayed for nearly three months before the dust settled … … Now, in the director’s view, compared with the final results, these storms are "only episodes"

It is true that people who write heroes, like heroes, must bear and endure.

Next page: Without light, we create light.

[car home Shantou Preferential Promotion Channel] At present, preferential activities are being carried out in Shantou market, with the highest preferential amount reaching an astonishing 140,000 yuan, which reduces the minimum starting price to 346,000 yuan. This substantial profit has brought unprecedented opportunities for consumers to buy cars. If you are interested in buying this luxury electric SUV, you may wish to click "Check the price of the car" in the quotation form to get a higher discount.

Mercedes-Benz EQE SUV adopts a brand-new design language, the front face design is more concise and dynamic, and the unique air intake grille is integrated with the headlights to create a sense of future technology. The overall style is fashionable and atmospheric, and the lines are smooth and powerful, showing the perfect combination of luxury and sports.

Mercedes-Benz EQE SUV has a body size of 4880mm long, 2032mm wide and 1679mm high, and a wheelbase of 3030mm, providing spacious seating space and excellent driving stability. The lines on the side of the car are smooth and dynamic, which shows the perfect combination of luxury and sports. Its tyre size is unified as 235/55 R19, and it is equipped with rims that sometimes have high grip, which further improves the handling performance and visual effect of the vehicle.

The interior design of Mercedes-Benz EQE SUV shows the perfect combination of luxury and technology. The center console is equipped with a 12.8-inch high-resolution screen, which provides a rich multimedia experience for drivers and passengers. The steering wheel is made of high-quality leather, with electric up-and-down and forward-and-backward adjustment functions, ensuring the best driving posture. The car is equipped with advanced speech recognition control system, which can control multimedia, navigation, telephone, air conditioning and skylight. There are USB and Type-C interfaces in the front and rear rows to meet the daily charging needs, and the front row is also equipped with wireless charging function. The seat is made of imitation leather, and the front and rear, backrest, height, leg rest and waist support can be adjusted in the main and co-pilot positions, which supports heating and ventilation functions and improves the riding comfort. The memory function of the electric seat provides convenience for the driver’s seat and the co-pilot’s seat, while the rear seat supports proportional tilting, which increases the flexibility of storage space.

Mercedes-Benz EQE SUV is equipped with an efficient and powerful electric engine with a maximum power of 300 kW and a maximum torque of 858 Nm, which provides excellent power performance and excellent acceleration experience for the vehicle.

After the test drive of Mercedes-Benz EQE SUV, the owner of car home said that although the power performance of the model was acceptable, the low-profile version lacked the function of rear wheel steering, resulting in insufficient flexibility. Compared with his previous BMW 3 Series, the handling of Mercedes-Benz EQE SUV is inferior. In addition, when he encountered a big pothole, he found that the car body was shaking obviously and the suspension system felt soft.

　　[car home Technology] After driving for a certain mileage, vehicles often have slightly different driving feelings from new cars, and the reason for this is ultimately attributed to the components that make up the vehicle. Therefore, we have done such a thing, completely disassembling a family car that has traveled 100,000 kilometers in a short time, which is the first time for us.

　　Because it is the first time to make such a topic, we found many problems in the planning process, which may lead to the failure of the dismantling project, such as the dismantling site, vehicles used for dismantling and related technical support. Therefore, we finally decided to cooperate with automobile manufacturers. After a long period of communication, Dongfeng Nissan Qichen accepted our proposal.

● Why choose a car that travels 100,000 kilometers for disassembly?

　　The reason why the mileage of 100,000 kilometers is selected is because when a car travels more than 100,000 kilometers, some faults and problems will gradually emerge, which has little to do with the brand and price of the vehicle, that is to say, even millions of high-end brand vehicles may have various problems.

　　By disassembling a vehicle traveling 100,000 kilometers (disassembling it to the most basic component level, such as a bolt or a bearing), we can tell you which components will wear, especially the chassis system and powertrain system, which are normal and which are abnormal, and how these wear will be related to the final vehicle performance. In this process, we will also tell you how to reduce this unnecessary wear in daily use.

●　Which car to dismantle?

　　Initially, we had several basic requirements for vehicle selection:

　　1. The longer the mileage is on the basis of 100,000 kilometers, the better;
　　2. The vehicle has not been modified in power and performance, and it is all set by the original factory;
　　3. The vehicle has not had any accidents;
　　4. The vehicle is the original paint;
　　5. The vehicle is normally maintained in the 4S shop according to the regulations.

　　The vehicle has not been modified and has not had an accident. At the same time, these conditions are maintained normally, and some interference factors are eliminated as much as possible. Only in this way can the contents presented by disassembly be more representative. Based on the above points, (click for details) we have collected vehicles in the forum. In addition, you may also see the collection information of vehicles in the 4S shop. After screening, a Qichen D50 was finally locked.

● Ran 100 thousand kilometers a year!

　　The Qichen D50 we chose has a mileage of more than 100,000 kilometers in more than one year, and the average daily mileage is more than 300 kilometers. We only know the reason by asking the owner. Because of business needs, car owners often drive back and forth between cities in the Pearl River Delta region. Most of the roads they drive are high-speed and relatively smooth national roads, while the rest are relatively congested and complicated urban roads.

● Where shall we open it?

　　Such disassembly requires the cooperation of the site and relevant personnel. At the same time, we also hope to send the vehicle to a professional institution for testing and verify the state of the vehicle through the test data. Based on the above demand, we transported the vehicle to Dongfeng Nissan Factory in Xiangyang City, Hubei Province for disassembly. It is worth mentioning that it can also be borrowed from the professional test site in the factory to evaluate the vehicle subjectively.

●　Basic information of the vehicle

　　This Qichen D50 was produced in April 2012, and the specific model is the 2012 1.6L manual comfort version. The owner bought this car in June last year. After buying a car, the owner first installed an electric rearview mirror in the 4S shop (it is indeed a very practical configuration, and the manufacturer seems to realize this, which became the standard of the whole department on the 2013 Qichen D50), an anti-theft device, a leather seat and a reversing radar. We found a slight crack at the adjusting button of the electric rearview mirror, which may be caused by the later installation.

　　For more than a year, the owner carried out routine maintenance in the 4S shop according to the provisions of the maintenance manual. At the same time, during the use process, the owner himself felt that there was abnormal noise at the position of the generator and the front shock absorber. After going to the 4S shop for inspection and maintenance, he finally replaced the generator and the right front shock absorber free of charge through the claim procedure. In addition, before lifting the new car, the engine harness was damaged due to the storage problem of the car, so the engine harness was also replaced.

● Owner’s evaluation of the car　

　　In more than a year’s use, the owner is satisfied with the overall performance of the car, and there has never been any breakdown on the way to and from the city. Because it is located in the high humidity and high heat environment in the south, the owner turns on the air conditioner every time he gets on the bus. According to the road conditions explained earlier, the fuel consumption is more than 6 liters per 100 kilometers, and the owner is quite satisfied with this fuel consumption. The owner also thinks that the noise of the engine of the car is relatively small and the gear is very clear. In addition, the owner is also very satisfied with the space performance of the car and the cooling effect of the air conditioner. As for the shortage, the owner thinks that the interior of Qichen D50 is too simple, and I think this is also a compromise that has to be made from the perspective of cost control.

● Editor’s subjective driving experience (static+dynamic evaluation)

　　The vehicle has been explained clearly, and after listening to the owner’s feelings about the car, let’s make a subjective evaluation. Let’s see what changes will happen to the vehicle driving 100,000 kilometers from the most intuitive feeling. To this end,We found a 2013 1.6L manual deluxe version of Qichen D50 (hereinafter referred to as the new car) with a mileage of only over 2,000 kilometers for comparison, thusFeel the difference and difference more obviously.

-Good appearance and interior color.

　　　Perhaps it is because of the relatively short service life and the care of the owner. In short, it is difficult for us to associate this car with driving 100,000 kilometers through static observation. Its appearance and interior color are good, and all functions of the vehicle are normal.

-Abnormal sound may come from generator pulley bearing.

　　After landing, under the condition of quiet external environment, there was abnormal noise coming from the pulley side of the engine crankshaft, and it was preliminarily judged that it came from the pulley bearing of the generator. If this is the case, it can be seen that the generator assembly replaced by claim has the same problem again. But whether the abnormal sound comes from here or not, we have to wait until the disassembly to find the real answer.

　-There is slight abnormal sound at the stop bar.

　　We found that this old car will have a slight abnormal noise when it is in gear, but it will not affect the clarity of gear and the feel of shifting. We feel that this abnormal noise is probably caused by the lack of adequate lubrication of the gear selection mechanism. In the later disassembly, we will further confirm the cause of the problem.

-The noise of the old car is slightly louder than that of the new one.

　　In terms of noise, we selected two points: idle speed and 80km/h (the engine speed is about 2000rpm after the manual gear D50 is engaged in the fifth gear at this speed) to compare and test the new car and the old car. From the results, the new car is better than the old car with a mileage of 100 thousand kilometers, but the advantage is relatively small, especially when idling, the abnormal noise from the pulley of the old car leads to the obvious noise of the old car in idling. In fact, the increase of noise is an unavoidable problem for any vehicle, because the rubber and related materials that play a role in sealing and sound insulation will age to a certain extent with the passage of time, which will lead to the noise can enter, thus making the noise of vehicles rise slightly.

-The dynamic performance of the old car is better than that of the new car before the running-in period.

　　In addition, we entrust a third-party testing organization to test the dynamic performance of two Qichen (one new and one old) (the tires are all new tires of the same brand and series). Judging from the final results, the dynamic performance of the old car that has traveled for 100,000 kilometers is better than that of the new car, and it is not unusual to see this situation. After all, the new car is still in the running-in period, and the power and chassis system have not yet reached the best running-in state. In addition, although the old car has been fully run-in, there will be a certain degree of attenuation in the power system, but the attenuation of this car is not obvious because of its good driving condition, which can also be confirmed by the disassembly of the engine and transmission of the old car in our later period.

-the new car is tighter and the old car is slightly loose.

　　In terms of actual driving experience, we choose to carry out it in a closed test site, where there are many different roads that can simulate the bumps, twists, speed bumps, asphalt roads, stone roads and gravel roads that vehicles may encounter when driving on actual roads.

　　By comparing the test drive of two vehicles, the first obvious feeling is that the new car is more compact and complete, while the old car is slightly loose. When passing through cobblestone sections, the interior parts of the two cars will have obvious abnormal noise, while the old car is more prominent. I think this may be related to the deformation of the plastic parts in the car after a certain period of use and the change of assembly clearance.

　　When I was driving at a speed of about 20km/h on a twisted road with ups and downs, I could obviously feel that the potential energy of the spring could not be reduced and absorbed quickly because of the performance attenuation of the shock absorber in the old car, which made the body bounce relatively greatly, while the body bounce of the new car was smaller. Based on this, we have to dismantle the shock absorber destructively in the later stage to see what happened inside the shock absorber, and please pay attention to our subsequent disassembly report.

Summary:

　　Through subjective driving experience, we have a preliminary understanding of the basic situation of the vehicle. In terms of appearance, interior and various functions of the vehicle, the vehicle has maintained a relatively new level. However, after all, I have already traveled 100,000 kilometers, and I immediately felt the obvious difference through driving. We have also recorded some good or bad situations found, and we will find the corresponding answers for everyone in the later disassembly. (Text/car home Feng Jingyi)

Next notice:

　　At the beginning of this topic, this paper mainly explains the daily use of this vehicle which has traveled for 100,000 kilometers. In addition, we will also analyze the subjective evaluation of static and dynamic driving, and find the answer to the question through detailed disassembly in the later period.

　　[car home Technology] With the increase of mileage, the aging characteristics of vehicles are becoming more and more obvious. For drivers, abnormal noise is the most intuitive category. As mentioned in our previous article, the owner judges that there may be some problems in the vehicle based on abnormal noise, and the subsequent inspection results also confirm the reliability of this intuition, and those silent changes are also taking place. We ended them when the odometer of Qichen D50 entered the 100,000-kilometer mark. This article will show you the situation of the body and chassis.

　　If you don’t know what we are doing, it is necessary for you to know the contents of the first stage, such as why we are doing this, how we choose the car, and of course, the general situation of disassembling the car is also very important. (Click for details)

The second stage: body disassembly

　　Don’t underestimate the structure of this energy-absorbing box. Through literal understanding, we know that its function is to absorb collision energy by virtue of its own deformation in the event of collision, so as to reduce the impact on the back.

　　It’s easy to say, but it needs careful design to achieve better energy absorption effect. On the one hand, the wrinkle design on its surface divides the energy absorption process of the energy absorption box into three parts, which makes the energy absorption process of each part relatively independent and stable, and the position and amplitude of these two folds are obviously calculated through a lot of calculations. In addition, the energy-absorbing box connected by bolts can effectively control the maintenance cost.

　　In the energy-absorbing box, different cars have different structures, some cars are not equipped with energy-absorbing boxes, some cars are equipped with energy-absorbing boxes but have no wrinkle design. In addition, there is a difference in the connection mode of energy-absorbing boxes. Some cars’ energy-absorbing boxes are connected with anti-collision beams and longitudinal beams by welding.

☆ Door disassembly

Further disassembly in the car

　　The next step is to disassemble the car body further. In the end, what we see is just a car body, just like the car body we see in the painting workshop every time we visit the factory. Although it is impossible for us to judge the anti-corrosion ability of the car body by using it for more than one year, when it is "naked" in front of us, we can clearly see the structure of the car body and the workmanship inside and outside. This is also a very noteworthy link.

☆ Passenger compartment structure

　　As we all know, the coating process carried out in the vehicle manufacturing process can ensure the corrosion resistance of the car body. As long as the paint surface of the car body is not damaged in the later use of the car, in general, the car body steel plate can be guaranteed not to be rusted in 10 years. Of course, the process of the steel plate itself is also very important. We learned from the manufacturer that the Qichen D50 uses galvanized steel plate with good corrosion resistance, which also ensures the aging resistance of the car body to a certain extent.

☆ Details of the cover

☆ The mystery of pedal

　　As we expected, there are no signs of years such as rust or dim color on the surface of the car body. For such a car with a driving time of about one year, it is really difficult to judge its anti-corrosion performance, but in any case, we can still gain something in the process of disassembling the car body, such as the materials and structure of the car body.

The third stage: chassis disassembly

　　According to our previous experience of comparing the test drive of new and old models, Qichen, which has traveled for 10,000 kilometers, did show some fatigue in the chassis link. For example, after passing through the ditch and ridge road for many times in a row, the vibration absorber’s ability to restrain the body shaking has declined, and we hope to find the answer in the subsequent disassembly.

● Suspension disassembly

● Front suspension disassembly

　　The front suspension structure of Qichen D50 is McPherson-style, and the process of detaching it from the car body together with the subframe is not complicated. The subframe and the car body are connected by four bolts, but before loosening them, we need to disconnect the connection between the damping strut and the car body and the engine support elements, and then the suspension assembly and the engine are detached together. Next, we will analyze the suspension disassembly, and the engine disassembly will be arranged at the end.

☆ steering rod ball

　　Under normal circumstances, the car that has traveled for 100,000 kilometers is prone to problems, which is the abnormal sound or looseness caused by the aging of the rubber parts of the chassis. The ball head of the steering rod is a part that is prone to problems. The ball head of the steering rod is responsible for connecting the steering rod and the steering knuckle. Besides the ball head, there is lubricating oil in it. Once the rubber sleeve outside is damaged due to aging, on the one hand, the lubricating oil will leak out; on the other hand, dust, dirt and rain may also enter the ball head, which will accelerate the wear of the ball head, and then the damping force on the swing of the ball head will become smaller, and its interior will begin to wear and gradually become loose.

　　For the driver, it may be felt that the virtual position of the steering wheel is getting bigger (loose and spacious, which can be felt by shaking the wheels with both hands after lifting the car). On the other hand, it will also affect the stability of the vehicle when it is dynamic to some extent. From the disassembly of Qichen D50, we can see that the steering rod ball head is in good condition, and the steering wheel is not found to be too empty during the previous test drive, so it can be judged that there is no problem in this part. However, the aging of rubber covers is also related to time, which generally does not happen when the car is used for more than one year.

☆ Steering knuckle and bearing

● Rear suspension disassembly

　　The rear suspension of Qichen D50 adopts the longitudinal arm torsion beam structure, and the simple structure is the advantage of this kind of suspension structure, especially for compact cars like Qichen D50, it is particularly important to contribute more space to the interior of the car.

● Brake pad wear

● Disassemble shock absorber

　　The situation that the body sway can not be suppressed as soon as possible is mostly directly related to the shock absorber. With the increase of mileage, its performance will gradually decline. In addition, continuous and high-intensity work will also reduce its performance.

　　Before disassembling, we made a static comparison of the height of the car body. In the case of no load, there was no obvious difference between the heights of the old and new cars, which to some extent showed that there was no big problem with the springs supporting the height of the car body. Next, we will further disassemble the shock absorber strut and shock absorber.

　　This kind of shock absorber with double-tube structure is widely used in ordinary household cars. After many times of intensive work, the hydraulic oil and air inside may be mixed together, which will lead to a large number of bubbles in the hydraulic oil. In this state, the performance of the hydraulic oil is bound to be greatly affected. This may be the reason why the car body shaking in Qichen D50 cannot be suppressed as soon as possible. The above is only our theoretical analysis according to the structure.

● Vibration isolation state between spring and car body

● Abnormal wear of tires

☆ Wear difference between front and rear tires

　　When cleaning up the workshop, we accidentally found that the removed tires showed signs of abnormal wear. Usually, this is related to the four-wheel alignment of the vehicle and daily use.

　　According to our understanding, the tires of this Qichen D50 have not been changed during the driving period of 100,000 kilometers. Only during the maintenance period, the maintenance technician found that the wear of the front and rear tires was obviously different, and the front and rear tires were switched. However, we can still see some clues from the wear of the tire surface.

　　For most (engine-front) vehicles, because the center of gravity of the vehicle is relatively forward, the pressure on the front tire is greater. According to the physical definition, the friction between the tire and the ground is greater when the contact area is fixed. In contrast, the wear of the front tire is more serious than that of the rear tire.

　　From this point of view, it is very necessary for us to switch the front and rear tires regularly during our daily car use, which can make the wear state of the front and rear tires more uniform, thus delaying the service life of the tires. Specifically, the front-back exchange or diagonal exchange can be adopted, but if the tire has a rolling direction mark, then the same side can only be used for the front-back exchange when the tire is transposed. This requires special attention.

☆ Eccentric wear of tires

　　In addition to the difference between the front and rear tires, the tires used as front wheels for a long time have eccentric wear. From the tire surface, the degree of wear on the outer side is more serious.

　　This may be a problem with the four-wheel alignment of the vehicle, but it may also be caused by the tire being in a state of insufficient air pressure for a long time. Modern cars tend to set camber to a negative value to improve the driving stability of the vehicle. If the tire is in a state of insufficient air pressure, it will aggravate the wear on the outside of the tire when the vehicle turns.

Editor’s summary:

　　The Qichen D50, with a mileage of over 100,000 kilometers, shows no obvious signs of aging in the body and chassis. Among them, because the service life of the vehicle is about 1 year, and under normal circumstances, the painting process can ensure that the car body will not be rusted for 10 years, so it is difficult to fully show the anti-corrosion state of the car body. In addition, in the chassis link, we focused on the problem of vehicle body sloshing after passing through the ditch and ridge. Through structural analysis, after many bumps, the mixing of oil and gas in the shock absorber may be the chief culprit leading to damping attenuation. No signs of aging were found in the rubber bushings between the various connectors of the chassis. On the one hand, the quality of the components themselves was excellent, on the other hand, it was related to driving habits and car use time. In the next article, we will disassemble the powertrain. Compared with the body and chassis, the driving of 100,000 kilometers is a greater test for this part. (Photo/Text car home Li Boxu)

　　[car home Technology] In the first two issues, we made a subjective evaluation of a Qichen D50 that has traveled for 100,000 kilometers, and tried to find out the possible changes of the chassis system and the body through disassembly. In this article, we will disassemble the core powertrain in detail to see what changes it will have after 100,000 kilometers of operation.

　　If you don’t know what we are doing, it is necessary for you to understand the contents of the previous stages, such as why we should do this, how we choose the car, and the disassembly of the body and chassis.

The fourth stage: engine disassembly

● Find the source of abnormal noise on one side of the engine pulley.

　　First of all, we have to remove the generator, air conditioning compressor and other accessories from the engine. We turned the pulley of the removed generator by hand, but we didn’t find the abnormal sound we heard in the subjective evaluation before. It can be seen that the abnormal sound didn’t come from this, and finally it was determined that the root cause was the tensioner.

　　Generally, the design concept of Japanese manufacturers is to achieve the initial requirements through the simplest structure as possible, so the design similar to Qichen, which is adjusted by screws, can automatically adjust the tightness of the belt according to the tightness of the belt, although it is not like the automatic tightening wheel designed by German manufacturers, but its advantage lies in its durability.

　　Although the belt connecting the engine accessories is not like the timing belt (most vehicles use timing chain nowadays), once it breaks, the intake and exhaust valves of the engine will be seriously damaged, but it also needs to be checked daily. If it strikes, the generator will not work and the vehicle will break down.

● Cooling circulation system

● clutch

● Wear of crank-connecting rod mechanism and valve timing mechanism

　　Both crank-connecting rod mechanism and valve timing structure run well after 100 thousand kilometers. Although you can clearly see the friction marks, they are all normal phenomena. This is not only due to the manufacturing accuracy, but also due to the engine oil, and changing the engine oil regularly is the best protection for these metal parts that are always in a harsh environment.

●　Variable valve timing system with high requirements for oil cleanliness

● Carbon deposition in injector and piston

● Carbon deposition in intake and exhaust systems

　　Although we often mention the word "carbon deposit", it will still be incredible when we see these things strongly attached to the relevant parts of the engine. Indeed, no matter how good the oil, car habits, car environment and other conditions are, carbon deposition is always inevitable, but some cars are more serious and some cars are less serious. For example, it is easier to form carbon deposition when driving on congested roads in cities, and once it is formed, it is difficult to completely remove it.

Stage 5: Disassembly of manual transmission

　　For friends who don’t know much about the structure of manual transmission, it is strongly recommended to click on the article "Manual transmission you don’t know: the mystery under the shift lever" to learn.

Full text summary:

　　After 100 thousand kilometers, the powertrain system is still in good condition, especially the degree of wear is low, so the importance of regular maintenance is self-evident. However, the generation of carbon deposit is inevitable. When it is serious, it will have a great impact on fuel consumption and power. If you want to completely remove it, you must completely disassemble the engine to solve it.

　　At this point, our topic of "100,000-kilometer vehicle dismantling" is over. Through dismantling, we show you what changes will happen to a vehicle that travels 100,000 kilometers, so as to help you develop good driving habits and strengthen the daily inspection and maintenance of the vehicle. As the saying goes, "three-point repair and seven-point maintenance", only in this way can we better enjoy the life of owning a car. (Text/car home Feng Jingyi)

　　Cctv news(Focus Interview): Speaking of big data, everyone is no stranger. At present, online shopping, mobile payment, smart transportation, epidemic prevention and control are all inseparable from the support of big data, which has been integrated into all aspects of our lives. There is a metaphor that data is the oil of the Internet economy. On May 28th, 2021 China International Big Data Industry Expo ended in Guiyang. The Expo was founded in 2015 and officially upgraded to a national-level Expo in 2017. Now it has become the vane of big data development and an international and professional platform. So what are the new features, new achievements and new applications of this year’s Digital Expo?

　　This year’s Digital Expo will focus on the "change" and "new" brought by big data with the theme of "changing intelligence and bringing new things". Due to the need of epidemic prevention and control, this year’s Expo has adopted the "online+offline" exhibition mode. The 40,000-square-meter offline exhibition area includes four theme pavilions, namely, the Frontier Technology Pavilion, the Smart Industry Pavilion, the International Complex Pavilion and the Digital Application Pavilion, to showcase new technologies, new products, new solutions and new applications of big data and the changes that big data has brought to people’s lives.

　　For exhibitors who can’t make it to the site, they can display their brand features and star exhibits with videos, pictures, documents and other information through the online display platform, and communicate with guests and professionals from all over the world online. The offline audience adopts the reservation system and visits at different peaks.

　　In the artificial intelligence exhibition area of the Expo, all kinds of robots are very attractive. The 5G remote ultrasonic robot can complete the whole process of remote ultrasonic diagnosis, and the new infrastructure, smart future and new experience based on 5G network have also become the focus of attention. The technology company exhibited a helmet monitoring system based on 5G network, artificial intelligence and big data technology. As long as you enter the designated area, the system will automatically identify whether you are wearing a safety helmet and give an early warning.

　　New products and applications of big data have also become more accessible in life. In the Smart Industry Pavilion, the smart system of an enterprise can collect the physical signs data of human body during sleep for a long time, process and analyze the data, and give personal health guidance programs. At present, this enterprise has cooperated with some old-age care institutions to explore a new model of smart old-age care.

　　With the empowerment of big data, cities become smarter. In this year’s Digital Application Pavilion of Digital Expo, this exhibitor from Shanghai brought new applications of big data. On this system, big data technology focuses on the key areas of Shanghai’s urban management and operation. The establishment of intelligent model can comprehensively monitor the overall state of urban water supply system, and send out warnings and reminders in time when problems are found.

　　In addition to the water system, the brain of the city has begun to predict in advance the fields of transportation, fire safety and smart parking.

　　Guizhou, the host of the Expo, is an important pioneer area for China to implement the big data strategy. Since the establishment of the National Big Data Comprehensive Experimental Zone in Guizhou in 2016, new achievements have emerged in the development and application of big data in the fields of economy, society and people’s livelihood. At this year’s Expo, the digital government work platform was displayed in the exhibition hall of Guizhou on the Cloud, which broke the data barrier and brought new changes to people’s lives through data exchange and sharing among different departments. At present, in the mobile terminal run by Guizhou Netcom, the government service functions of different departments are classified together.

　　The technical application of the smooth flow of data not only makes people run less wrong roads, but also shows their talents in consolidating the achievements of poverty alleviation. Heiyan Village, jiangkou county, Tongren City, used to be a second-class poverty-stricken village, but now it has been lifted out of poverty. Some time ago, Guizhou Poverty Alleviation Cloud Big Data System sent monitoring and early warning information to Heiyan Village: More than half a month ago, a villager named Long had heart surgery in the Municipal People’s Hospital, and the village cadres needed to verify the situation as soon as possible. In the morning, the poverty alleviation cadres came to the villager’s home.

　　After confirming that the medical expenses and other related expenses did not pose a risk of returning to poverty for this family, Hu Yinxi logged the verification results into Guizhou Poverty Alleviation Cloud System.

　　Such a big data monitoring system has strict authority settings and shields personal sensitive information, mainly monitoring the data of unexpected situations that have the risk of returning to poverty in production and life. At present, Guizhou Province has included groups such as unstable poverty-stricken households and marginal households in the scope of big data monitoring. If there is a risk of returning to poverty or causing poverty, it will accurately analyze the reasons and eliminate the risks through effective measures.

　　This year is a crucial year for consolidating and expanding the achievements of poverty alleviation and effectively connecting with rural revitalization. After several years of development, big data technology has been applied in rural revitalization. Therefore, this year’s Digital Expo has also set up a section called "Big Data Helps Rural Revitalization". From the aspects of big data and rural environmental governance, rural e-commerce, tourism and agricultural industry integration, we will demonstrate and explore big data to empower rural revitalization.

　　The key to rural revitalization is to do a good job in industry. The "pepper cloud" on display at a booth caught the attention of reporters. On the "Pepper Cloud" platform, the data of the whole industrial chain, such as planting process, agricultural science and technology, meteorology, soil, humidity, landform and detection, are integrated, and big data technology is used to promote standardization for scattered farmers.

　　The "Pepper Cloud" platform, which breaks the problem of data collection and promotes standardized planting, relies on smart phones and big data model algorithms to insert wisdom wings for small peppers in mountainous areas. In Taiping Village, Zheng ‘an County, Guizhou Province, the 500-acre pepper planted by villager Wan Hong grew well, but weeds grew in the field and the pepper branches grew to the length of pruning. Wanhong, who was at home at this time, received a reminder from the agronomist on the platform on her mobile phone.

　　In a short time, in addition to a large area of weeding in wanhong’s pepper field, he quickly took out his mobile phone and took a few photos of the on-site completion and uploaded them to the "cloud platform" of the mobile phone.

　　On the "Chili Cloud" platform, whether the work is qualified or not is calculated by the data brain.

　　In addition to showing the latest applications of various innovative technologies based on big data in economic and social fields, the number fair has also become a new platform for the competition and development of innovative technologies. At this Expo, the announcement of the results of the selection of leading scientific and technological achievements awards attracted much attention. Among the 49 award-winning projects finally selected, seven projects including the research and application of bus-level data center network technology won the Black Science and Technology Award.

　　"The number of wisdom changes, and things are new." After seven years of development, the Expo has not only become a platform for the display and exchange of innovative technologies, but also built a bridge for the integration of China’s big data industry with the world and become an important platform for attracting foreign investment.

　　Big data has been widely used in China’s economic and social development, and the pattern of rapid development of big data industry has basically taken shape, but it still faces many challenges in data open sharing, core technology breakthrough and big data-driven development. The Expo provides a platform for innovation, integration and communication to meet these challenges. For the development of big data that has become a national strategy, activating, mining and applying big data and exploring more new technologies, new formats and new models can generate greater value and empower high-quality development.

From April 30th to May 2nd, the 2023 Hua Chenyu Mars Concert Chengdu Station officially ended! Hua Chenyu gathered with tens of thousands of fans to start a three-day music carnival. The super shocking visual stage, the free wear of Mars, the tear-jerking two-way rush, and the journey home with the clock in eating and drinking… All of them are haunting, which together constitute a full memory point of the journey to Mars Chengdu, and live up to the distance of thousands of Martians! On the last night of Chengdu Station, fans did their best to shout for Hua Chenyu, pushing the atmosphere of the scene to a high point several times. Under the dream-like stage design, Hua Chenyu released the musical tension to the fullest, singing from 14:07 pm to 22:00 pm for three consecutive days. During the three-day carnival, the romance of "fireworks" went everywhere in both directions, and the family-like relationship made everyone feel happy at first sight, and it has been a long time! The wonderful appearance of the Martian utopia makes all the previous efforts and waiting have color.

Mars playlist carefully arranged to show sincerity "Hope" physical album is about to be launched

In the three-day performance of Chengdu Station, different playlists were configured every day: on the first day of the playlist, Hua Chenyu sang "Mountains and Seas" in the "sea of people", which filled the atmosphere of the May Day holiday; on May 1, in addition to "My Skateboard Shoes 2016", "The Return of the Master", etc., it was also a surprise to prepare a long improvisation for the fans, and the love for the fans was carefully mixed in every music note, making it difficult for every Martian who came to the scene not to be moved; on the last day of the performance, he also covered the song "Can Beautiful Things Happen to Me", which was adapted from Hunan Satellite TV’s top music synthesis "Sound Life Endless Treasure Island Season". The solo performance that night won wide praise and became the "golden song" of the "Three Gong" performance Received praise from the original singing band "Constantine’s Change Ball" Weibo, and the two sides also met friends as singers, officially following each other on Weibo. Now, the live version of the concert is also to make up for his regret of performing on the stage of "Sound Life Never Ending Treasure Island Season". He once said that he hoped that this song would bring healing power to the outside world, "Good things can happen to us!" And through music to export correct values to the outside world, encouraging people to better heal the earth after a short charge on Mars, is also Hua Chenyu’s insistence. On the evening of May 2, Huahua was still at the end of the performance, and it was surprising to reveal that his fifth new singing album "Hope" will be released to the outside world after the holiday. This physical album is still available in USB and CD versions. Hua Chenyu incorporates dialectical thinking into the album, encouraging everyone to immerse themselves in their own dawnism. The release of the physical album explores fantasy and reality in a more realistic form, and will definitely bring an extraordinary musical experience to the outside world.

"Fireworks" go to N tear-jerking performances in both directions, freedom, tolerance and happiness merge into the romantic base color of Mars

In addition to repeatedly polishing the music, stage and styling, and constantly mobilizing the fans’ musical visual ceiling, the Mars Concert also strives to bring the best home experience to fans. On May 2, Hua Chenyu Studio and the official blog of the Mars Concert released the "Welcome Home" poster at 13:14 at the same time. The "Lifetime" arrangement touched every Martian resident, and they shouted: Huahua understands the sense of ritual! On the afternoon of the 2nd, the fans who were drawn to the stage to play mahjong just wore a red Lolita "flower wedding", and ran to the idol they missed through the vast sea of people, filled with romantic details. Fans enjoyed the freedom of dress and spiritual freedom under Huahua’s carefully crafted utopia. Diversity and inclusiveness have also formed the long-standing romantic base color of Mars. Even if you are not a "Martian" in the true sense, it is difficult not to be infected by the atmosphere here. Hua Chenyu said sincerely on the spot: There may be some people who are not my fans, but when you come to Mars, we are family. This is a place where you can get warm after working hard and tired on Earth. He also enjoyed providing such a place for the soul to live, and the prosperity ended. The beauty of Mars scenes still flashed in everyone’s minds repeatedly. The snow of "Meeting When Flowers Fall", the volley ribbons of "Born into the Sun", the aerial roses of Hangzhou Station… "When the flowers fall next year, the flowers of Mars are in full bloom." "Fireworks" has become a part of the romance while fulfilling its promise to create romance.

The 2023 Hua Chenyu Mars Concert Chengdu Station ended successfully, and the short separation of this journey is also the beginning of the next journey. Looking forward to the 2023 Hua Chenyu Mars Concert Wuhan Station, Hua Chenyu will bring tens of thousands of Martians to his hometown in Hubei to continue writing more beautiful chapters on Mars.

On September 22, according to the feedback from IT Home netizens, the installation experience package of Xiao Ai’s large model version has been announced, and Xiaomi users can download the experience.

According to the official introduction, Xiao Ai, who is blessed by the big model, has achieved a new upgrade and now supports functions such as text generation, personalized assistant, content summary, character customization, picture generation, multi-language translation, and Xiaomi product assistant.

Xiaomi users click the download button at the bottom of the event page and select "Original Installation Package Download". If they don’t see "Original Installation Package Download" (as shown in the right picture above), they need to upgrade the app store to the latest version and try again. (IT Home Note:)

In addition, users can also open "My" – "My Download" on the homepage of the browser to find the downloaded installation package, click Open and select Allow the browser to install the application, and then follow the steps to complete the installation.

It should be noted that the large model version of Xiao Ai only supports the installation experience of Xiaomi devices.

IT House previously reported that the first batch includedMi Mix Fold 3Xiaomi Mi 13/12 series, Redmi K60/K50 series models. After that, Xiaomi launched two invitation tests on August 21 and August 24, including Xiaomi MIX Fold 2, Xiaomi Mi 11 series, Xiaomi Mi 10 series, etc. Xiaomi users who did not catch up with these three tests can try the download experience.