1905 movie network news The romantic blockbuster directed by John Woo was officially released in the Mainland on December 2nd. Based on the sinking of the Taiping wheel in the history of China, this film tells three love stories of three couples. Shipwreck? Love? Many people will think of the film directed by James Cameron that touched millions of people at the first time. In fact, the Taiping Wheel was once called "Titanic of China". There are many similarities between these two films: they are both based on the real shipwreck in history, with love stories as the core, and they both spend a lot of money to restore the shipwreck scene at that time with scenery and special effects, and one third of the special effects of Taiping Wheel were completed by the original special effects team of Titanic.

　 　 However, John Woo believes that his films and Cameron’s works are two very different films. The latter takes place almost entirely on ships, but the former is not. Its time and space span is broader, emphasizing the fate of characters under the background of war. And according to him, the ending of this movie is more optimistic than Titanic. What the truth is, I think the audience will have their own minds after watching the film. But before watching the film, you can follow us to learn something that won’t be told on the screen: how did John Woo conceive his love story? What kind of disaster is the sinking of the real Taiping wheel? How is the grand disaster scene created?

David and Zhang Ziyi.

The action movie guide of "Violence Aesthetics": Love seems not to be John Woo’s domain.

　 　　Cameron is famous for his sci-fi action movies:, series, all sci-fi movies, and "Card God" rarely touches simple love stories. So is John Woo. For many years, he has been labeled as "action film director" and "violence aesthetics". Whether he became famous in the 1990s, or he marched into Hollywood’s FACE/OFF, until his last work, it was an out-and-out action blockbuster. However, the director had a wish to shoot a romantic film as early as after filming "The True Color of Heroes", but this wish has never been put into practice. Although the Taiping Wheel has a broad background and grand scenes, involving politics, home country and other issues, the center of the story is placed on love.

　 　　The film tells three love stories: one is the love between young people in Taiwan Province and Japanese girls, the other is the love between Kuomintang officers and Shanghai rich girls, and the other is the love between prostitutes and communication soldiers. They were adapted by Wu Yusen according to his own experience and stories, and there is no direct correspondence with historical figures. Different from the difference in wealth and status between the two protagonists in Titanic, these three love relationships can basically be called suitable couples. Wu Yusen has his own view of love. In his view, love means responsibility. Although he is not opposed to love at first sight, he believes that whether he can persist after love at first sight is the most important issue of love.

　 　　In fact, Titanic is a story of persistence. Although the love in this film starts with the love between Jack and Rose at first sight, its value lies in that Jack can make sacrifices for love after the collision, while Rose can carry on living with this love. Similarly, Taiping Wheel focuses on the power of love and the courage to survive. John Woo hopes to show the greatness of love in turbulent times. No matter what the times are, love will never change. He intends to leave hope for the audience at the end of the film: although things are chaotic and disasters are inevitable, the last survivors have the courage to live.

Song Hye Kyo and Huang Xiaoming.

Open the sense of space with three stories: tell three different kinds of love.

　 　　If the cross-class love of Titanic falls into the stereotype, then the love of Taiping Wheel is not so fresh, and its role setting always makes people feel deja vu. However, the connotations of the three love stories are different. Lei Yifang, a Kuomintang officer, and Zhou Yunfen, a rich lady, were played by Huang Xiaoming and Song Hye Kyo respectively. They met at a dance after War of Resistance against Japanese Aggression’s victory and got married soon. After the outbreak of the civil war, Lei Yifang once again set foot on the battlefield, leaving his new wife and children in his womb. Zhou Yunfen suddenly walked out of the carefree world and had to deal with the chaotic world and difficult life alone. Only then did she realize how important her husband’s love is. This is a story of cognition and growth. Thanks to the turmoil of the times, love is no longer superficial, but has become profound.

　 　　David and Zhang Ziyi, who play the role of messenger Tong Daqing and prostitute Yu Zhen respectively, live at the bottom of society. The former belongs to Lei Yifang’s troops and is optimistic and cheerful; The latter receives guests at night and takes care of the wounded during the day, and has a strong personality. However, the relationship between these two people is not strictly love, but more like a relationship of caring for each other. They came together just to survive, out of the need for each other. Yu really loved her first boyfriend. She didn’t know that her boyfriend had died the moment she boarded the Taiping wheel. She is a passive role, and she doesn’t have many choices, but she persists in living. It is love that keeps her going, even if it can’t be realized in the end.

Masami Nagasawa and Takeshi Kaneshiro.

　 　　Taiwan Province young man Yan Zekun and Japanese girl Masako are played by Takeshi Kaneshiro and Masami Nagasawa. Yan Zekun is a Japanese military doctor who was captured by Tong Daqing in the Sino-Japanese War. The love between him and Masako is pure love of mutual consent. Both of them are simple people, but the differences in nationality and culture and the opposition of Yan Zekun’s mother have greatly hindered their love. Like Yu Zhen, these two characters are also somewhat passive. Probably born in that era, it is difficult for anyone to hold their destiny firmly in their hands. All they can do is struggle. But the separation was inevitable. Yan Zekun got on the boat with a lot on his mind. He didn’t know that there was a huge disaster waiting for him.

　　Few things touch people’s hearts as much as health. Health care is the key to people’s livelihood.

　　More new drugs are on the market, "noble drugs" are included in the medical insurance drug list, the "healthy China" action plan is deepened, and the chaos of medical beauty is rectified with heavy blows … … In 2019, these medical and health events related to people’s livelihood attracted special attention. At the end of the year, people hope to further "improve quality" and "reduce prices", and expect relevant departments to prescribe more health "prescriptions" to continuously improve people’s sense of acquisition and happiness.

　　one

　　Responding to the challenge of drug resistance, Tu Youyou team clarified the mechanism of artemisinin drugs

　　Artemisinin is a gift from traditional Chinese medicine to the world, which has contributed to the global malaria control. However, in recent years, the underlying mechanism of artemisinin in the treatment of malaria is still unclear, especially the problem of drug resistance, which is also the biggest challenge facing the global malaria control.

　　The half-life of artemisinin in human body (the time required for drug concentration to drop by half) is very short, only 1-2 hours. The course of clinical recommended artemisinin combination therapy is 3 days, and the truly efficient insecticidal window of artemisinin is only limited to 4-8 hours. However, the existing drug-resistant insect strains make full use of the short half-life of artemisinin, change their life cycle or temporarily enter a dormant state to avoid the sensitive insecticidal period. At the same time, plasmodium can also produce obvious resistance to the auxiliary drug "antimalarial formula" in artemisinin combination therapy, which makes artemisinin combination therapy "ineffective".

　　On April 24th, Tu Youyou’s team published an article online in the top international medical journal "New England Journal of Medicine", saying that the recently clarified mechanism of artemisinin drugs shows that they are precursors activated by iron or heme. Iron and heme are by-products of hemoglobin digestion, reaching the highest concentration at the mature stage of plasmodium trophozoite. Once artemisinin drugs are activated, many protein and heme of parasites will be alkylated. Alkylation of heme can also inhibit the detoxification of heme. "It is speculated that the mutation of a single protein target is unlikely to cause drug resistance, which may also explain why artemisinin drugs are still effective after decades of widespread use." Wang Jigang, a member of Tu Youyou’s team and a researcher at Artemisinin Research Center of Chinese Academy of Traditional Chinese Medicine, said.

　　In this regard, the team proposed a new treatment response plan: First, appropriately extend the medication time; The second is to replace the adjuvant drugs that have developed resistance in artemisinin combination therapy.

　　2

　　Can the "white list" of medical beauty be cured?

　　Non-medical beauty places are engaged in medical beauty treatment, the practice of doctors with informal training, and the use of unqualified medical beauty products … … In recent years, the "three non-"chaos exposed by the media has repeatedly been criticized by the society.

　　On June 18th, the National Health and Wellness Committee indicated that China Plastic Surgery Association was studying and formulating a credit evaluation management system, and it was planned to conduct credit evaluation of beauty medical institutions in some areas on a pilot basis. "The data of hardware conditions and facilities, annual inspection and doctor qualification of medical beauty institutions will be connected with the existing credit system, and a medical beauty institution &lsquo will be established in the future; White list ’ , objectively present to the people ‘ White list ’ The situation of the organization. " Cao Dequan, deputy secretary-general of China Plastic Surgery Association and director of the evaluation office, said that at that time, the public can search for information on the special website.

　　Hu Jieren, an associate professor at Tongji University Law School, said that the system itself is highly scientific and operable. It can learn from the existing credit evaluation model, listen to social voices, list the characteristics of dishonesty, and ensure fair and strict punishment. At the same time, in addition to credit evaluation and other mechanisms, the governance of medical beauty chaos requires multi-dimensional efforts and the participation of the whole society. For example, the regulatory authorities should take the initiative and increase penalties.

　　three

　　The Healthy China Action Plan is issued. Everyone is the first person responsible for his own health.

　　In July, the "Healthy China Action Promotion Committee" established in the State Council released "Healthy China Action (2019— 2030), giving authoritative guidance on what to do, how to do it and who will take the lead in healthy China.

　　"Everyone is the first responsible person for his own health." Wang Xiaoning, director of the Institute of Geriatrics of the General Hospital of the People’s Liberation Army and secretary-general of the China Association for Science and Technology’s life science association, particularly agreed with this point in the document. He explained that WHO has already concluded that in the promotion and maintenance of national health, the contribution of medical care is less than 10%, which mainly depends on people’s lifestyle and living environment. Wang Xiaoning said: "It turned out that ‘ Grip ’ The focus is on the 10% part, and now it is necessary to put ‘ Grip ’ Put it in 90%, that is, people’s lifestyle and living environment. "

　　Experts say that it is not enough for doctors and health departments to embrace health. Cardiovascular and cerebrovascular diseases are the first cause of death among Chinese residents, "Healthy China Action (2019— In 2030), it is mentioned that the goal of healthy China will reduce the premature mortality rate of major chronic diseases from 18.5% in 2015 to no more than 15.9% in 2022. Yang Jingang, an associate professor at Fuwai Hospital of China Academy of Medical Sciences, believes that the goal can only be achieved by mobilizing social forces, and the organizational model of "Patriotic Health Campaign" can be used for reference. Only by linking disease prevention and control indicators with the performance and responsibility of district leaders can we coordinate all resources and really play a role.

　　four

　　Major projects support the initial establishment of a drug innovation technology system in China.

　　In view of the difficulties and expensive medical treatment for ordinary people, and the heavy dependence on imports of high-end medical equipment and drugs, as early as 2008, China deployed and implemented the major scientific and technological project of "major new drug creation" (hereinafter referred to as the new drug creation project).

　　"With the special support of new drug creation, a total of 14 Class 1 new drugs were approved after February 2017, showing a blowout growth." At the end of July, at the conference of "Creation of Major New Drugs", Chen Kaixian, deputy chief engineer of special technology and academician of Chinese Academy of Sciences, introduced that in the past two years, new progress has been made in the research and development of special varieties, and six Class I new drugs have been approved for the treatment of malignant tumors. In addition, the achievements of the special project of new drug creation include the first domestic and the second long-acting anti-AIDS drug, the new anti-infective drug, Clindamycin, which is independently developed, and the world’s first aromatic hydrocarbon receptor modulator and non-hormonal small molecule chemical drug, Benvimod & HELIP, which has therapeutic effect on psoriasis. …

　　The national drug innovation technology system has been initially established in the special project of new drug creation, and a series of technical platforms have been laid out; Initially, a grid-based innovation system with scientific research institutes and universities as the main source innovation, enterprises as the main technology innovation, the close integration of the upper, middle and lower reaches and the deep integration of politics and Industry-University-Research has been established, and the ability of independent innovation has been significantly improved.

　　five

　　The paper has sparked a heated discussion on whether "Aristolochic acid-induced liver cancer" is a real hammer or a misunderstanding.

　　In August, aristolochic acid once again became the focus. Han Zeguang, a professor at systems biomedicine Research Institute of Shanghai Jiaotong University, published a paper in the international journal Hepatology in the field of liver diseases, which was emphasized by many media as "aristolochic acid has caused liver cancer to have a real hammer". This study revealed that aristolochic acid alone can cause liver cancer in mice in a dose-dependent manner, that is, the greater the dose of aristolochic acid, the shorter the time to cause liver cancer and the larger the tumor. When aristolochic acid is combined with carbon tetrachloride, it can induce liver cancer in mice in a dose-dependent manner, including hepatocellular carcinoma and hepatocellular carcinoma and intrahepatic cholangiocarcinoma.

　　However, Luan Yang, a researcher at Shanghai Jiaotong University School of Medicine, and others believe that the data obtained by Han Zeguang’s team under certain experimental conditions are not enough to draw the conclusion that aristolochic acid causes liver cancer, and it cannot be called a "real hammer". "Specific experimental conditions" means that the experimental object is young mice and carbon tetrachloride liver injury model.

　　Some experts also said that some media interpreted the latest experiment of Han Zeguang’s team as "solid hammer" evidence that aristolochic acid is the main cause of liver cancer in China, but it should be noted that the original literature is in young mice (equivalent to 1-mdash; 2-year-old baby) and carbon tetrachloride liver injury model, which is different from the clinical occurrence of liver cancer, and many independent studies have been published in the world for many years, but no results of liver cancer caused by aristolochic acid have been made in adult mice, so it is too early to think that aristolochic acid is the main cause of liver cancer in China.

　　six

　　The original research drug went to sea for the first time, and the national research anticancer drug was approved for listing in the United States.

　　A movie, Dying to Survive, made anticancer drugs attract public attention. Subsequently, zero tariffs on imported anticancer drugs and negotiations on anticancer drugs have also become hot spots of public concern.

　　On September 23rd, the National Health and Wellness Commission and other 10 departments jointly issued the Healthy China Action — — Cancer prevention and treatment implementation plan (2019— In 2022) (hereinafter referred to as the "Program"), the "Program" pointed out that a set of "combination boxing" will be made by unblocking the temporary import channels of anticancer drugs that are urgently needed in clinic, promoting the substitution of generic drugs, and incorporating them into medical insurance, so as to improve the accessibility of anticancer drugs and enable ordinary people to buy, afford and use anticancer drugs in China.

　　The "Proposal" clearly stipulates that the zero tariff on imported drugs should be promoted, and various links such as R&D, production, procurement, import and use should be fundamentally straightened out, and the price of anticancer drugs will continue to decline, further promoting the simultaneous listing of new overseas drugs in China and avoiding the "foreign moon and domestic circle" caused by the difficulty in obtaining anticancer drugs.

　　Nowadays, the situation of "only getting in but not getting out" of original anticancer drugs has been broken. On November 14th, zanubrutinib, a BTK inhibitor developed by Baekje Shenzhou Company, was approved by the US Food and Drug Administration (FDA) for the treatment of adult patients with mantle cell lymphoma who had received at least one therapy before. At this point, "the drug became the first new anti-cancer drug independently developed by local enterprises in China and approved for listing by the FDA, realizing the new drug originally developed by China ‘ Zero breakthrough ’ 。” Dr Wu Xiaobin, general manager and president of Baekje Shenzhou China, said.

　　seven

　　Supervision is imminent. E-cigarettes are as harmful as traditional cigarettes.

　　Some businesses advocate that e-cigarettes are less harmful to human body and can help smokers quit smoking. Self-adjusting taste, cleanliness and environmental protection, and convenient use have all become eye-catching labels of e-cigarettes.

　　"Generally speaking, e-cigarettes will highlight the characteristics of high technology content and trendy fashion in product performance and ingredients. However, the ingredients of e-cigarettes are nothing more than nicotine, water, spices, propylene glycol and glycerol. As for the principle, it is even simpler, just an electronic evaporation, and there is no technology content at all." Zhang Zhigang, a senior engineer of China Environmental Behavior Law Society, said.

　　More seriously, consumers don’t know that under normal use conditions, the concentrations of some metals (including lead, chromium and nickel) and formaldehyde in some e-cigarette aerosols are equal to or higher than those in traditional cigarettes, and these harmful substances are even higher than the content of second-hand smoke produced by traditional cigarettes. In addition, e-cigarettes will also produce some toxic substances that are not found in traditional cigarette smoke, such as glyoxal, which is flammable, toxic and irritating, and its vapor or fog will stimulate eyes, mucous membranes and upper respiratory tract.

　　With the United States, Japan, India and other countries banning e-cigarettes to varying degrees, the voice that China should legislate and supervise e-cigarettes as soon as possible is getting louder and louder. Hu Qingyuan, director of the National Tobacco Quality Supervision and Inspection Center, said: "Fortunately, we have already started to act." On November 1, the State Tobacco Monopoly Bureau and the State Administration of Market Supervision jointly issued the Notice on Further Protecting Minors from E-cigarettes, urging enterprises or individuals that produce and sell e-cigarettes to withdraw their e-cigarette advertisements published through the Internet, and the supervision of e-cigarettes is becoming increasingly strict.

　　eight

　　Can cerebral palsy be cured? "Needle-sealing therapy" triggered a normative discussion on new therapy.

　　Cerebral palsy is recognized by the medical community as incurable. However, the media reported that the Third Affiliated Hospital of Zhengzhou University (hereinafter referred to as the Third Affiliated Hospital of Zhengzhou University) adopted "needle sealing therapy" for children with cerebral palsy (the full name is "point plus acupoint drug injection therapy"), and the hospital claimed to evaluate 381 children. The results showed that 190 cases, that is, nearly half, were normalized.

　　On October 21st, an article questioned the "needle sealing therapy" invented by Wan Guolan, the founder and honorary director of the Children’s Rehabilitation Department of the Third Affiliated Hospital of Zhengda, and the "needle sealing therapy" was pushed to the forefront. Sun Yong ‘an, chief physician of the Department of Neurology, Peking University First Hospital, said that "needle sealing therapy" is more of a gimmick, and even if it is effective, its effect is limited. Nerve injury is generally caused by congenital development or acquired injury. If it is cerebral palsy caused by poor nerve development in the embryo, even if there is some growth compensation, it is still difficult to completely cure it.

　　Cerebral palsy is difficult to treat, and there is no standard single treatment. Some experts said that we should not arbitrarily think that all self-created therapies are ineffective. Because medicine is a practical subject, it is advancing through constant exploration and trial, and some new therapies really need to break through the routine. However, the technology applied in clinic should be universally recognized and supported by evidence-based medicine. To carry out a clinical trial, first of all, the institutions involved and the researchers involved in the trial must have the qualifications to carry out clinical research; Second, it is necessary to carry out strict registration and filing, and strictly design the test plan, demonstration and modification; Third, it should be recognized by clinical trial management institutions and ethics committees; Fourth, the subjects should have the full right to know, the experimenter should ensure the safety of the subjects, and the subjects have the right to withdraw at any time during the treatment. As for the efficacy of the new therapy, it also needs a large sample of randomized double-blind controlled studies to verify it.

　　nine

　　At the dawn of treatment, "small molecular glue" can devour the pathogenic protein of Huntington’s disease

　　Involuntary dance-like movements, cognitive impairment and mental abnormality … … Huntington’s disease is one of the four major neurodegenerative diseases. Because the biochemical activity of the mutant Huntington’s protein (mHTT) causing the disease is unknown, it can’t be targeted. The traditional method of blocking the activity of the pathogenic protein by blocking agents is not suitable for the treatment of the disease.

　　At the end of October, researchers from Fudan University published their achievements in Nature, and found a "small molecular glue" that "devours" Huntington’s disease-causing protein through screening based on compound chips and cutting-edge optical methods, which is expected to bring new dawn to the clinical treatment of Huntington’s disease.

　　In the study, the team focused on controlling autophagy, an intracellular protein degradation pathway, to effectively reduce the level of mutant Huntington protein. In order to solve the problem of "self-injury", the team imagined to invent a kind of "small molecule glue", which can aim directly at the bull’s-eye, firmly stick LC3 and pathogenic protein (or other pathogenic substances) together, and then wrap the pathogenic protein into autophagy bodies for degradation. After screening, purification and a series of cell experiments, the research team obtained four kinds of "small molecular glues" that can bind LC3 and mutant Huntington protein.

　　According to team member Lu Bojun, at least two of these four compounds can cross the blood-brain barrier and directly reduce the level of mutant Huntington protein in the cerebral cortex and striatum of Huntington’s disease mice through low-dose intraperitoneal administration, without affecting the level of wild-type Huntington protein in brain tissue, and also improve the disease-related phenotype, which provides a breakthrough point for the development of oral or injection drugs for Huntington’s disease, and is expected to be applied to motor coordination disorders, facial twitching and muscle spasms.

　　10

　　"Aristocratic Drugs" Self-devalued Medical Insurance Drug List Negotiation to Reduce Patients’ Burden

　　Only when good drugs enter medical insurance can people finally get benefits.

　　In December, the National Health Insurance Bureau released the National Drug List of Basic Medical Insurance, Work Injury Insurance and Maternity Insurance in 2019 (hereinafter referred to as the Drug List). The results showed that 97 of the 150 negotiated drugs were successfully negotiated, and the average price dropped by 60.7%. This is also the largest since the establishment of the medical insurance system in China, with remarkable results.

　　During the negotiation, the National Medical Insurance Bureau spared no effort in bargaining. Take the shortlisted hepatitis C drugs as an example, four companies directly measure the quotation on the spot, and the quotation of each drug should be accurate to two decimal places. There are two quotations in total. If both of them fail to reach the psychological price of the medical insurance bureau, or exceed 15% of the medical insurance payment standard, they will be directly out. In the end, Ledipaviso fosbuvir tablets from Gilead Scientific Company, fosbuvir patavir and Elba Wegera Rive tablets from Merck were selected with an average decrease of 85%.

　　Xiong Xianjun, director of the Department of Medicine Management of the National Health Insurance Bureau, said that the significant reduction in drug costs is one of the results of this negotiation. By giving play to the role of the medical insurance department as a "strategic buyer", the drug costs will be greatly reduced by changing the price. A number of world-renowned "noble drugs" have been marked with "civilian prices", and imported drugs have basically given the lowest price in the world. It is conservatively estimated that through negotiation of price reduction and medical insurance reimbursement, the personal burden level of patients will be reduced to less than 20%, and individual drugs will be reduced to less than 5%.

It has been more than two years since the outbreak of COVID-19 at the end of 2019.Sequela of COVID-19Discussions on related topics have never stopped.

"COVID-19 may cause permanent damage to male sexual function?"

"terror! More than 200 kinds of sequelae of COVID-19 are difficult to cure for life! "

"COVID-19 after cure, sequela emerge in large numbers! Experts uncover the cruel truth … "

Since February this year, with the spread of Omicron mutant and its subfamily, the epidemic has rebounded and spread on a small scale in many cities in China. The constant variation of COVID-19 virus has always kept the "sequela of COVID-19" in the fog. However, the growing number of recovered people in COVID-19 has rapidly fermented the fear of COVID-19’s sequela. We can see this fear from the emotional distribution of public opinion about COVID-19’s sequela on social media.

　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 Click to view a larger image.

Obviously,Fear occupies the absolute majority of public opinion.But it seems that some people are slowly accepting the sequela of COVID-19. This may be related to the difference in toxicity between Omicron strain and previous strains. However, people’s negative emotions still dominate the mystery of COVID-19’s sequela.

Is the sequela of COVID-19 really terrible?The medical community can’t give an exact answer at present, especially in the context of Covid-19’s continuous evolution. However, infectious diseases have always been the main diseases threatening human health, and even to some extent, infectious diseases and human beings have jointly constructed social life and history. Perhaps from the history of human infectious diseases for thousands of years, we can find some traces of answers.

In history, have humans ever defeated infectious diseases and their sequelae?

Infectious diseases break out at different stages of human development, andThe human struggle against the sequelae of infectious diseases is always in a continuous state.. This persistence lies not only in the fact that its sequelae will still have a long-term impact on the recovered after the epidemic of infectious diseases has been controlled, but also in the fact that it takes a long time for human beings to recognize the sequelae caused by these widespread infectious diseases.

Not every infectious disease will cause sequelae, butEvery disease that may leave sequelae for the recovered has left an indelible mark on human history.. Looking back at the development history of infectious diseases that left sequela problems, it is not difficult to find the power of these diseases.

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For thousands of years,Only smallpox is the only truly eradicated infectious disease in human history.While other infectious diseases are still dormant in every corner of the earth. Before the birth of modern science, human beings didn’t fully understand viruses and bacteria, and there were still many puzzles about what infectious diseases were, how they occurred and how to effectively prevent, deal with and contain them, especially for the sequelae of infectious diseases.

Overcoming the sequela of COVID-19, it seems, is not a short process.

How long does it take to correctly understand a sequela?

In the face of the sequelae of infectious diseases, human beings, like other temporarily unknown things, seek answers from practical experience and try to establish their understanding of the sequelae of infectious diseases.

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As the experience of fighting SARS, hepatitis B and influenza shows,The study of sequela is based on the epidemic of infectious diseases, and the long-term sequela makes the study of sequela lag behind the occurrence of epidemic of infectious diseases for a long time.The outbreak of hepatitis B in China was from 1970 to 1992, but the number of related studies on the sequelae of hepatitis B reached its peak in the 21st century.

At the same time, the pathogens of some infectious diseases are constantly changing and updating.It seems that the sequela of infectious diseases and human beings have also become an endless tug-of-war.Influenza virus has undergone many mutations during its epidemic thousands of years. For example, the 1918 influenza virus, known as the "mother of pandemic", has been studied, and almost all influenza A (except avian influenza virus, such as H5N1 and H7N7) in the world since then are its descendants. The research on the sequela of influenza has been going on for centuries, but so far it has not been able to give a definite conclusion.

A large sample study of sequelae of COVID-19 also needs a long time span. At present, there have been achievements in the research of COVID-19’s sequelae in the medical field, and the research object is mainly COVID-19 patients in 2020, and there is a great difference between the infected strains of COVID-19 patients in 2020 and the popular Omicron variant.The sequela of COVID-19 is still an unpredictable variable.

What are the consequences of the unknown sequelae?

Academic research itself lags behind the outbreak of infectious diseases, and human beings are often in the blank or limited cognition of diseases and their sequelae for a long time.Faced with the unknown, out of worry and fear, people may avoid patients with diseases, and even breed group malice against patients.

Just as people are sensitive and uneasy about "COVID-19" nowadays, from the end of 20th century to the beginning of 21st century, Chinese in this period fell into a panic about "Hepatitis B".

Hepatitis B virus carriersThere is a certain probability of complications such as hepatocellular carcinoma, chronic active hepatitis with or without cirrhosis. The serious illness made people nervous for a while, and also made hepatitis B carriers bear numerous social pressures at that time. The word "hepatitis B discrimination" also comes from this.

"hepatitis b discrimination"It refers to giving different, often unreasonable and unequal treatment to hepatitis B virus carriers outside the conditions stipulated by law. The wrong understanding of hepatitis B is the root of social prejudice and discrimination. At the same time, there are many patients with hepatitis B in China, and the social discrimination against hepatitis B patients and hepatitis B virus carriers is more serious.

China’s laws and regulations related to hepatitis B are gradually improved and perfected in the exploration of hepatitis B cognition.

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At the end of 1980s, the research on hepatitis B in the medical field was not clear, and hepatitis B was mistaken for being highly contagious, and many rights and interests of hepatitis B carriers were restricted. Since the 21st century, with the deepening understanding of hepatitis B, especially the frequent occurrence of cases of discrimination against hepatitis B, the society and the country have gradually paid attention to this issue. According to the actual situation, relevant departments have promulgated and implemented a number of laws and regulations to solve the problems.

In 2010, atNotice on Further Standardizing the Physical Examination Items for Admission and Employment and Safeguarding the Admission and Employment Rights of HBsAg CarriersAfter the introduction, local governments and relevant departments responded in succession to protect the enrollment and employment rights of HBsAg carriers. It was also in this year that the number of laws and regulations related to hepatitis B reached its peak, and then it became more and more stable.

From the beginning of "talking about the color change of hepatitis B" to the later protection of rights, it is inseparable from the gradual establishment of objective cognition by all sectors of society and joint efforts to eliminate discrimination.Getting rid of people’s sensitivity and anxiety about "COVID-19" may also be inseparable from this process.

At present, more than 550 million COVID-19 patients have been confirmed in the world, and nearly 530 million people have been cured. The increasingly prominent sequela problem in COVID-19 has brought double challenges to academic research and policy planning. The sequela of COVID-19 needs the public’s attention and understanding, and the implementation of intervention measures by all sectors of society. The academic research of COVID-19’s sequela is not clear, and the policy planning of COVID-19’s sequela in China is still in the exploratory stage.

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At present, the country has explored COVID-19’s sequela policy from the aspects of advice, rehabilitation platform and economic subsidies.Some places have also begun to build rehabilitation hospitals in Kangding. For example, Suzhou City has designated the People’s Hospital of Suzhou Taihu National Tourism Resort as the designated rehabilitation hospital in COVID-19. It is imperative for the state to improve relevant measures as soon as possible to protect the rights of patients with sequelae of COVID-19 in the post-epidemic era. Whether it is necessary to further implement assistance to patients through legislation and other measures like hepatitis B remains to be discussed.It still needs some distance to get rid of people’s sensitivity and anxiety about "COVID-19".

How far are we from getting rid of the anxiety of "COVID-19 Sequela"?

If we want to know how far it is from getting rid of the anxiety of "COVID-19 sequela", we must first know what caused people’s anxiety about COVID-19 sequela. From people’s discussion on COVID-19’s sequela, we can find some key points.

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The anxiety about COVID-19’s sequela may be related to the influence of COVID-19’s sequela on the body.Symptoms of COVID-19’s sequela have attracted much attention. Besides symptoms, nouns such as fatigue, hepatitis, taste and adjectives such as fatigue also appear frequently. The academic circles can’t determine exactly what the "symptoms" of COVID-19’s sequela are, but in the discussion of COVID-19’s sequela, the impression of "COVID-19’s sequela" has gradually formed.

Click to view larger image.

Although these impressions may not be supported by scientific evidence, they will inevitably cause some panic.The influence of COVID-19’s sequela on mental state is often discussed, and adjectives such as "anxiety", "fear" and "depression" appear many times. Women, the elderly, etc. are also mentioned as the possible susceptible groups of sequelae of COVID-19.

Apart from paying attention to COVID-19’s sequela symptoms and personal emotional state,The anxiety about COVID-19’s sequela may also be related to the influence of COVID-19’s sequela on social life.In the phrase "life", keywords such as "dismissal" and "work" have also been discussed to some extent.

On May 29th, 2022, a blogger "I’m a little monster" who returned to COVID-19 for rehabilitation claimed that the organization where he worked as a Russian teacher asked to leave after learning that he had been infected with COVID-19. She said that she had done 50 or 60 nucleic acids, and all of them were negative. She also hoped that the society would be more tolerant and understanding to the recovered people in COVID-19.

Some people understand the reason why she was fired: "Because this disease will recur endlessly, and once you recover, everyone who comes into contact with you will become close or sub-close, and they may all face isolation … But please believe that everyone is kind, not discriminating, but afraid of separation and life and work stoppage." Some people also talk about similar experiences or concerns with bloggers. "When the cabin came back, people in the same building saw me close the door with a thief." "The little monster is still a hot self-media on the Internet. What about others? What should other ordinary people infected with COVID-19 do if they encounter such a thing?"

In fact, this blogger’s situation is not a case.A report published by The Lancet found that some people failed to return to their pre-infection work status or work after COVID-19 was infected, butThe reasons for losing one’s job are directly or indirectly related to COVID-19’s sequelae.

Click to view a larger image.

How far are we from getting rid of the anxiety of "COVID-19 sequela"?

What effect COVID-19’s sequela will have on the health of COVID-19’s recovered people is an unpredictable variable, which needs to be verified by the medical community in time. If we want to form a reasonable attitude of society towards COVID-19’s rehabilitated people, we need all sectors of society to work hard to eliminate inequality and irrationality.

Mark Twain once said, "History will not repeat itself, but just like the rhyme of the article, similar events will happen again." The distance between us and getting rid of the anxiety of "COVID-19 sequela" is the same as that between human beings and other infectious disease sequela panic in the past.

　

Is the sequela of COVID-19 really terrible? History will give the answer.

References:

1. Shen Guoqiang, Ren Huiyan, Zhou Long, Wang Zhangye, Yan Xiaoyi. Study on the response policy and evaluation system of novel coronavirus epidemic [J]. Science and Technology Herald, 2021,39(05):87-98.

2. Zhang Wenhong, "Zhang Wenhong said pollution", CITIC Publishing House

3. World Health Organization https://www.who.int/zh/

4. Law on the Prevention and Control of Infectious Diseases (until 2021)

5.Lixue H，Qun Y，Xiaoying G,etal.1-year outcomes in hospital survivors with COVID-19:a longitudinal cohort study[J].Lancet(London,England).398(10302):747-758.

6. Emerging Infectious Diseases, an academic journal of CDC in the United States, January 2006, Volume 12, No.1, with the title of 1918 Influenza: Mother of All Pandemic Diseases.

7. People’s Network

http://www.people.com.cn/wsjk/wsjk11/112/pvw894121.htm

8.https://baijiahao.baidu.com/s? id=1725511321170854939&wfr=spider&for=pc

https://news.sina.com.cn/s/2020-03-15/doc-iimxyqwa0649265.shtml

https://xueqiu.com/9936619624/140976983

Author team:Dong Jieyun Lin Huan He Qing

Instructor:Bian Qing

Tongji University Art and Media College "Integrated Media Reporting" Course Column

Contact information of the author:

19821236527 (mobile phone)

1037002425@qq.com (mailbox)

Produced by:Tongji university college of art and media

Original leon ye pinwan

Author: leon ye

Mailbox, yeliyan@pingwest.com

The official price of Samsung Galaxy Z Fold2 5G (hereinafter referred to as Fold2) is as high as 16,999 RMB, which is probably the most valuable digital product I have ever used.

As the successor model of Samsung Galaxy Fold, which was released in December last year, the Fold2 launched by Samsung only nine months ago did not attract as much attention as its predecessors. Even though the first generation of Fold has many shortcomings in products, as the first mass-produced folding screen mobile phone, the significance of its smooth sale is greater than everything else-"the first foldable screen mobile phone that can be bought" is enough to support the sky-high price of the first generation of Fold of 15,999 yuan among geek players.

Fold2, which has unloaded all kinds of "first" auras, must be examined in a more practical context. As a long-term user of the original Fold and other brands of folding screen mobile phones, I bought this Fold2 at my own expense on the day of the launch of the Bank of China out of my crazy love for all geek toys. During the National Day holiday, I used Fold2 as much as possible to replace other digital devices I have, and traveled light-the purpose is to test what Fold 2 can do and what the experience is in the second year after the folding screen device entered our hands.

A more usable mobile phone: wider external screen and stronger camera module.

No matter how it is defined, Fold2, a folding screen device, first exists as a smart phone-from my own experience, it really takes me far more time to fold and use the original Fold as a mobile phone than when it is unfolded as a tablet.

As an ordinary smart phone-this is the most lacking part of my experience when I used the original Fold in the past. The narrow external screen of the first generation of Fold makes most of the routine operations we have long been used to on mobile phones extremely difficult-typing, reading a slightly longer message, or even just pulling down the notification bar and clicking the next button to switch songs. The probability of wrong input is much higher than that of doing the same operation on ordinary mobile phones.

Fold2′ s outer screen is bigger, and most importantly, it has finally widened. The most intuitive comparison is that the width of the Fold2 outer screen is actually wider than that of the iPhone SE generation. Of course, compared with the ordinary smart phone that is nearly 7 inches now, the Fold2 outer screen is still mini, but its size absolutely ensures the usability of ordinary operations. Cheers, users who are used to full keyboard typing like me. The crazy experience when using the original Fold is gone forever.

▲ The external screen of Fold 2 is wider than that of iPhone SE generation.

Although the effect of opening the Fold2 and using the huge internal screen as the viewfinder is very shocking when taking pictures, I still use it as a mobile phone to take snapshots in the folded state in daily use. During the long vacation, in addition to scanning codes and documents, I also used it to take photos of my travels and share them on social media. As far as the proofs are concerned, although the colorful style of Fold2 is not to my taste, the imaging of wide-angle, main camera and telephoto camera is definitely more than enough for social sharing. It is worth mentioning that the phase quality of the night scene mode on Fold2 is quite good, and the progress is very great compared with the level that the original Fold is close to unusable.

▲ 1.0x main sample

▲ 2.0x telephoto proofs

▲ 0.5x wide-angle proofs

As a smart phone, thanks to the enlarged external screen and camera module with better imaging quality, the usability of Fold2 is significantly improved compared with the original Fold.

A better tablet: durable inner screen and durable hinge.

So how about unfolding Fold2 as a flat plate? We should know that the first generation of Fold media evaluation machine was collectively recalled and the sale was postponed, which was caused by the fragile internal screen and the need to improve the design. Of course, I won’t abuse the Fold2 I bought at my own expense like JerryRigEverything, but from the test results, the UTG ultra-thin glass used in the Fold2 and the improved screen frame buffer pad have enhanced the firmness of the Fold2 screen and ensured that users don’t need to protect their mobile phones too much like taking care of babies.

The durability has also been improved, as well as the hinge part of Fold2. This time, Samsung also brought a similar design in the hinge of Galaxy Z Flip, a mobile phone with the same folding screen, to Fold2, adding a small brush for dust prevention. Similarly, from the actual measurement of JerryRigEverything, the new structure has a quite good barrier effect on dust and sand.

▲ The test that you definitely won’t do proves that Fold2 is dustproof (Source: JerryRigEverything)

As far as my own short-term use experience in the past three weeks is concerned, there is no damage to the inner screen and hinge-a few scratches caused by the fierce battle of Wild Fighting only appear on the protective film pasted at the factory. This protective film, which Samsung does not recommend users to remove by themselves, may be very important for the protection of the Fold2 inner screen, but it is similar to the sticky feeling brought by rubber to fingers, which also compromises the smooth touch that the ultra-thin glass of the inner screen should have.

As a flat panel, Fold 2 removes the huge "oblique bangs" on the original Fold, uses a perforated camera design, and adopts a screen with a high refresh rate of 120 Hz and excellent impression, which can be said to have achieved a leap in entertainment experience. With dual speakers and the Flex mode brought by the hovering hinge, Fold2 is the best entertainment equipment for me when I watch games during the intermission of travel and in hotels. Among them, the new 120 Hz high refresh rate internal screen, which brings the greatest improvement to the look and feel, not only stays in fluency, but once and for all solves the problem that the left and right half screens of the original Fold are not synchronized when the refresh rate is 60 Hz.

▲ Flex mode (Source: Samsung)

It is true that Fold2, as a tablet, also needs to face the App adaptation problem common to almost all other Android tablets. But after solving the regret left by the original Fold on the screen and hinge, Fold2 has evolved into a better tablet.

A good computer: software and hardware that need to be improved

In the past three weeks, I unexpectedly enjoyed using my Fold2 as a computer-although Samsung officials did not make any publicity in this regard. During the trip, a portable Bluetooth keyboard was connected and the bracket of the fiber protective case was opened, and Fold2 became a small notebook computer. Samsung’s adaptation to multitasking on the software level is very complete, from split screen and windowing to Edge Panel side screen panels that can be exhaled at any time. Fold2, which combines all these functions, with the good endurance of the machine itself and the support for 5G, is fully qualified for the notebook role used for code words when traveling.

▲ Fold2 that I used as a laptop.

Of course, to truly become your next computer, Samsung Fold series needs more improvements-for example, Samsung must add support for first-party accessories of Fold series, including magnetic keyboard and S Pen; For example, Fold products should be allowed to directly enter the dex desktop mode like Samsung Galaxy Tab S7 after an external keyboard is connected. For example, the current Dex desktop mode still has a lot of room for improvement, and there is still a significant delay when using the scroll wheel for sliding operation, and so on.

It is completely feasible to use Fold2 as a computer now-for example, this text was written entirely on Fold2-but to make it fully competent for this role, Samsung needs to make more efforts in both software experience improvement and hardware adaptation.

Practice from Imperfect to Perfect

Even in 2020, when the price of the flagship mobile phone has already exceeded 10,000 yuan, it is still very difficult to defend any mobile phone with a asking price of nearly 17,000 yuan-but from my actual experience in the past three weeks, the functions realized by Fold2 are completely worth its seemingly outrageous price-whether Fold 2 is folded as a mobile phone or unfolded as a tablet, these two experiences are very close to the top level of these two categories. In the second year after the folding screen entered the mass production market, Fold2, as Samsung’s answer sheet, was almost perfect.

But almost perfect means still not perfect. Among consumer electronics products, computer manufacturers have also begun to try to apply folding screen technology to broaden the application scenarios of notebook computers. Will mobile phone manufacturers represented by Samsung take over the desktop torch of mobile phones that started from Motorola Atrix 4G and continue to explore and try in the direction of mobile productivity?

▲ Application of Folding Screen in Notebook Computer ThinkPad X1 Fold (Source: Lenovo)

In addition, although from the evaluation of a number of technology media and the evaluation of buyers, Fold2 has indeed been favored by technology aborigines, but the generally high price of folding screen equipment is still the biggest resistance to the public users. The entry-level version of Fold, which had been rumored for a long time and was more affordable to the people, failed to appear at this year’s Samsung Galaxy Unpacked conference. It seems that it will take time for this rapidly mature technology to enter the hands of the public.

However, it only took less than a year from the first generation of Fold to the almost perfect Fold2, which has nothing to do with the word "perfect"-and the practice of folding screen technology will not last long from the crowd to the public.

Original title: "Can the folding screen mobile phone be the main machine? I tried Samsung Fold2 on National Day.

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On February 1st, 2024, the official official of Netease Cloud Music announced the new function "Live Cover" on the new play page, and by displaying the full-screen dynamic cover of songs on the vinyl play page, all users can get an immersive experience when listening to songs. And increase the creative exhibition space for songs, so that each song can be presented to users in a more comprehensive form, creating a new form of publicity channel for musicians.

As we all know, since Netease Cloud Music went online, its classic vinyl player interface came into being, and this design style has become an iconic part of Netease Cloud Music. When Netease Cloud Music is mentioned, vinyl records will automatically appear in users’ minds. With the constant change of users’ listening preferences and the continuous update of product functions, Netease Cloud Music is also trying to provide users with more possibilities for listening to songs.

After the previous market and user research, Netease Cloud Music decided to launch a new function "Live Cover" from two aspects: user’s immersive listening experience and song information display. It is reported that the "dynamic cover" function can dynamically display the contents of the cover of a song in full screen when the song is played, providing users with an immersive listening experience, and presenting the temperament and atmosphere created by the song in a more three-dimensional way.

The dynamic cover content will be created and generated by the musician himself or AI system according to the song content, which will show the song creation concept and other contents more comprehensively. The sharing function of the song "dynamic cover" reaches more users through sharing links and other forms, and builds a communication bridge between musicians and fans.

In view of this new function, which can improve users’ listening experience, many musicians have also actively participated in the creation and joint release of dynamic cover of songs. Well-known rap musician Ma Siwei’s popular cooperation single "Do That" released on January 20th took the lead in matching the dynamic cover effect, giving fans a New Year surprise, and many fans gathered in the comment area to call the song cover "so handsome". At the same time, many musicians, including Jude, Jony J, KEY.L Liu Cong, Sheng Yu, Prism Band, Kung Fu Pang, Dark Bar, etc., have matched the corresponding dynamic covers for their new special and representative works recently. From now on, users can go to the relevant songs and choose the "classic vinyl" player mode, so that they can experience the brand-new service provided by the "dynamic cover" function.

Netease Cloud Music also said that on the one hand, this move can better satisfy users’ richer, differentiated and diversified listening experience, and at the same time help musicians create another new channel for content announcement.

According to the survey of relevant users, in recent years, with the increasing demand of users for listening to songs, users have shown strong interest in how to meet the needs of listening to songs in different scenes in the playing page, and also have a strong interest in supporting different styles, lyrics and various effects in the playing page. Therefore, Netease Cloud Music has launched a new "dynamic cover" function through several months of research and development, which also shows its emphasis on user needs.

At the same time, in today’s increasingly fierce competition for content announcement, Netease Cloud Music has also created another new channel for musicians to communicate with fans through functional innovation in the station, giving them a new space to express their creative ideas.

In fact, this is another update of users’ listening experience recently launched by Netease Cloud Music. Previously, Netease Cloud Music successively launched functional innovations such as recall coordinates, music encyclopedia, and style daily push, and added a variety of brand-new player skins, which added more diversified music listening fun to users. In the future, Netease Cloud Music will still focus on the user experience and bring more high-quality sound services to users through innovation in functions and service modes.

Beijing Medical Insurance Fa [2020] No.1

The district medical insurance bureaus, the Finance Bureau, the Social Affairs Bureau of Beijing Economic and Technological Development Zone, the Financial Audit Bureau, and the relevant designated medical institutions:

　　In order to conscientiously implement the spirit of the important instructions of the Supreme Leader General Secretary on the pneumonia epidemic in novel coronavirus, in accordance with the decision-making arrangements of the CPC Central Committee and the State Council, and according to the Notice of the State Medical Insurance Bureau and the Ministry of Finance on Doing a Good Job in Medical Security for the Pneumonia Epidemic in novel coronavirus (No.5 [2020] of the State Medical Insurance Bureau) and the deployment requirements of the municipal party committee and municipal government, we will earnestly do a good job in the medical security work for the treatment of patients with pneumonia in novel coronavirus. We hereby notify the relevant matters as follows:

　　First, fully understand the importance of prevention and control of pneumonia in novel coronavirus. Doing a good job in epidemic prevention and control is of great significance for ensuring the health of the insured, maintaining social harmony and stability, and ensuring that the people have a stable and peaceful Spring Festival. Medical insurance and financial departments at all levels should attach great importance to it, and resolutely implement the relevant arrangements of the CPC Central Committee, the State Council and the municipal government with a highly responsible attitude towards people’s health. The main responsible comrades of medical insurance departments at all levels should take the lead, establish a special working mechanism, cooperate with health and other departments, and actively do a good job in joint prevention and control.

　　Two, the relevant designated medical institutions should do a good job in the procurement of drugs related to the treatment of pneumonia in novel coronavirus, to ensure the clinical needs. If it is necessary to urgently purchase drugs outside the sunshine procurement platform, it can be purchased first and then filed according to regulations.

　　Third, ensure that patients are not affected by the cost problem. First, for the medical expenses incurred by patients with pneumonia diagnosed in novel coronavirus, after the basic medical insurance, serious illness insurance and medical assistance are paid according to the regulations, the personal burden will be subsidized by the finance and comprehensive protection will be implemented. Second, for patients who have been diagnosed with pneumonia in different places in novel coronavirus, they should be treated first and then settled, and the reimbursement should not be reduced. Third, the drugs and medical services used by patients with pneumonia diagnosed in novel coronavirus are in line with the diagnosis and treatment plan of pneumonia infected in novel coronavirus formulated by the health department, and can be temporarily included in the scope of medical insurance fund payment.

　　Four, to ensure that the designated medical institutions are not affected by the payment policy. For designated medical institutions with more patients, part of the funds can be paid in advance to reduce the pressure of payment by designated medical institutions. Timely adjust the total budget indicators of designated medical institutions, and separately account for the medical expenses of patients with pneumonia infected in novel coronavirus. Medical insurance agencies at all levels should ensure timely settlement with designated medical institutions to ensure the smooth progress of treatment.

　　Fifth, ensure the smooth and orderly holiday work. Medical insurance and financial departments at all levels should strengthen the duty on duty during the Spring Festival holiday, improve the duty system, and implement all policy tasks to the letter. Medical insurance agencies at all levels should be equipped with sufficient personnel to ensure uninterrupted service during the Spring Festival holiday. In case of major problems and situations in the work, please report to the Municipal Medical Security Bureau and the Municipal Finance Bureau in a timely manner.

Beijing Municipal Medical Security Bureau

beijing finance bureau

January 23, 2020

Harley-Davidson STREET750 motorcycle

STREET?750

The official price starts at 86,800.

• 750CC water-cooled REVOLUTUONX?

Diablo style water-cooled is not afraid of traffic and takes the lead in busy traffic.

The throttle is smooth and responsive, allowing you to shuttle freely in the traffic flow, showing free and easy.

The power is still equipped with the previous 750cc water-cooled V-Twin, which is 47hp and 59 N m that broke out at 3750 rpm; And it is 233kg.

• Optional protection (ABS)

Precise factory installation of ABS helps you to control it calmly and under control.

The appearance of the vehicle adopts Harley-style black cast aluminum, dark style front end with Café style, the fuel tank is decorated with steel chrome-plated badge, and the exhaust is the only design of the two.

• Small lifting force

Because of its light weight and low center of gravity, you can kick off the temple bar, and the Harley-Davidson Street750 can be lifted easily.

Pull the car back from the side of the road. It’s as easy as pressing the starter button with your thumb.

• Low seat height

The height of the seat is only 711 mm. And the riding is more relaxed and flexible.

When the green light is on, the advantages of low-seat models will be revealed.

With a low center of gravity, you are confident enough to walk freely in the busy traffic, as simple as driving slowly through the parking lot to find a parking space.

The rear dual shock absorption is specially adjusted and optimized according to the vehicle weight and the seat position; Officials say that the ABS anti-theft system installed with the original factory can bring a more stable driving experience.

• Carefully tuned shock absorber

This motorcycle has been carefully adjusted according to its weight, geometric structure and rider’s position.

When encountering bumpy roads, the riding is still stable and the handling is still excellent.

The narrow design and the ultra-low seat height of 720mm can bring people a more relaxed and flexible driving experience, and the new locomotive wants to start with Harley’s first choice.

• Black domineering custom appearance

All-black 2-in-1, black cast aluminum, dark front section with cafe-style speed screen, and steel chrome-plated badge on the fuel tank.

• Customization set off a motorcycle revolution.

Help you build a unique Harley-Davidson motorcycle.

This STREET750 is Harley’s current entry-level model.

On January 8, 2023, the 20th Guangzhou International Automobile Exhibition (hereinafter referred to as "Guangzhou Automobile Exhibition") held in New Year’s Eve came to a successful conclusion. At the same time, the official said that the 21st Guangzhou International Automobile Exhibition will open from November 17th to 26th, 2023.

According to the official, this year’s Guangzhou Auto Show opened the newly-built D-Zone Pavilion of the Canton Fair for the first time, with an exhibition scale of 220,000 square meters, attracting a total of 383,000 visitors.

On the first day of media day, we welcomed the launch, listing and pre-sale of more than 60 heavy new cars. In this summary article, you will see: Great Wall Shanhai Gun, Wei Brand Blue Mountain, Chang An Yi Da, Hongqi H6, brand new Crown SportCross, brand new Crown Sedan, brand new BMW M2, brand new Civic TYPE R and brand new Mazda CX-50, etc. The 20th Guangzhou Auto Show can be said to be a successful conclusion for the automobile circle in 2022.

　　【Chexun. com reported】On November 2, 2024 (Chongqing), Aouita Science and Technology announced that the future smart luxury car — — Aouita 12 pairs of power officially listed. The new car has launched a total of six models with pure electric power and extended range power, and the official price starts from 269,900 yuan; The price of the Royal Theater Edition is 429,900 yuan. From now on, users can order through official channels such as Aouita App, Aouita official website, Aouita applets and stores in major cities across the country, and the products will be delivered as soon as they are listed.

　　At the same time, in view of the listing of the brand-new Aouita 12, Aouita also launched a heavy car purchase courtesy, with a maximum value of 27,000 yuan. Before November 13, 2024, Dading users can enjoy four limited-time rights: the first owner’s lifetime three-electricity warranty, the insurance subsidy coupon of up to 7,000 yuan, the equivalent deduction coupon of 20,000 yuan ADS high-level function package, and the zero down payment and low interest for the whole term. In addition, you can also enjoy five basic rights and interests: five-year or 120,000-kilometer vehicle warranty, eight-year or 160,000-kilometer three-power warranty, unlimited mileage free road rescue during the vehicle warranty period, giving away basic traffic of vehicle networking and 10G cockpit entertainment traffic every month, and giving away advanced ADS function packages.

　　As the flagship car of Aouita, the new Aouita 12 deeply integrates the core technological advantages of Changan Automobile, Huawei and Contemporary Amperex Technology Co., Limited, and is advanced in power, intelligent driving, safety and luxury experience. Chen Zhuo, president of Aouita Science and Technology, said: "The newly upgraded Aouita 12 will become the only choice of extended-range power, the only choice of Huawei’s three-laser intelligent driving and the only choice of all-factor luxury cockpit among high-end cars of the same class."

　　Kunlun extended the journey and blessed Gankun Zhijia, and the high-value experience was advanced in an all-round way.

　　Facing the increasingly diversified and continuously upgraded user demand, Aouita Science and Technology, with its profound accumulation and forward-looking insight in the field of smart electric vehicles, continues to deepen technological innovation and carefully lay out the product matrix, and constantly creates new travel experiences beyond expectations for consumers.

　　As the second product of Kunlun extended-range technology, Aouita 12 extended-range car will be the first high-end extended-range car in the industry, meeting the travel needs of users with more yuan and higher quality. The new car adopts the full-stack self-developed Kunlun extended range technology, and is matched with Contemporary Amperex Technology Co., Limited 39kWh Xiaoyao super battery, which brings the extremely powerful, extremely quiet and extremely worry-free car experience comparable to pure electric vehicles. In terms of power, the Aouita 12 extended-range version feeds 100 kilometers with an acceleration of 7.2 seconds, which is only 0.5 seconds worse than that of full power, and the attenuation in the extended-range field is the lowest; At the same time, the Aouita 12 Extended Range Edition can achieve the strongest acceleration in the industry for 25 consecutive times without attenuation. In terms of quietness, through the application of new technologies such as the world’s first electronic oil pump, the active control of the unique stop piston at the same level, and the noise reduction of the strongest electric drive in the industry, the quiet performance of the idle speed of 37.7dB and 120km/h is as low as 64.7db. In terms of battery life, pure electricity can reach up to 245km, comprehensive battery life can reach up to 1155km, and fuel consumption under WLTC condition is as low as 5.8L/100km. Aouita 12 extended-range vehicle is also the only extended-range vehicle in the industry that can add 92 # gasoline.

　　At the same time, Aouita 12 pure electric vehicles have also been fully upgraded. The new car is equipped with Huawei’s latest generation DriveONE silicon carbide electric drive, which is small in size, light in weight and strong in heat dissipation. The maximum power of the dual electric appliances is 402kW, the maximum torque is 687N·m, and the acceleration per 100 kilometers is as low as 3.8 seconds, providing users with a strong and lasting power experience. At the same time, all Aouita 12 pure electric vehicles are equipped with 800V silicon carbide platform as standard, which brings a rapid recharge experience. It only takes 20 minutes to charge from 30% to 80%, and with the maximum cruising range of 755km, the trip is more efficient.

　　In addition to the overall upgrade of power performance, Aouita 12 also has top intelligence. The new car comes standard with Huawei Three Lasers and Gankun Zhijia ADS 3.0. Among them, ADS 3.0 can learn and simulate human driving decisions independently through the scene understanding of GOD, the end-to-end network of PDP and the instinctive safety network, and provide users with a more human-like, more efficient and safer end-to-end intelligent driving experience. For example, in the intelligent driving navigation, you can realize "parking space to parking space, one-click self-opening". Whether starting from the parking space in the basement or the parking space on the roadside, Aouita 12 can achieve end-to-end navigation from parking space to parking space. At the same time, the ability boundary of navigation assistance has also been greatly improved. You can enter the parking gate independently, and through the difficult scenes such as roundabout and U-bend, the whole scene of urban travel is perfectly opened.

　　In addition, Gankun Intelligent Driving ADS 3.0 has also brought all-round active security protection to Aouita 12. Aouita 12 also upgraded Gankun omni-directional anti-collision CAS3.0, which achieved all-round improvement in the working boundary, forward/backward and lateral protection of the system. For example, the maximum braking speed of Aouita 12 can reach 120 kilometers per hour, which is the highest in the industry; The effective range covers 4 km/h to 150 km/h, which is the widest at the same level. In addition to complete active security, Aouita 12 has also built solid protection on passive security. The hybrid cage body design made of ultra-high strength steel and aluminum has a rock-solid safety factor; The 8 airbags and rear side airbags in the whole cabin can better protect passengers’ arms and trunks in side collision, and bring users all-round and multi-level safety protection.

　　The leapfrog configuration is supplemented by original design, and "new luxury" is achieved in every detail.

　　Entering the car, Aouita 12 has a unique leapfrog configuration at the same level, bringing a million-level luxury experience. The only front seat with double zero gravity at the same level achieves an excellent balance between sports support and luxury and comfort. One-button zero gravity, heating, memory, massage, remote start of ventilation, 16-way electric adjustment and other functions bring users a comfortable experience like being in the cloud. Entering the back row, Shuang Yi has a large space, the largest at the same level; The distance from the occupant’s hip to the ceiling and the back of the front seat can be close to 1 meter, which can be easily realized whether it is lying flat in the back row, doing yoga, stretching and other actions. At the same time, Aouita 12 also provides users with the strongest fully functional sofa in the back row, which supports the functions of seat heating, ventilation, massage, and extended central armrest with control panel. In particular, the suspended canopy screen in the rear cabin, with a large turnover angle of 60-100, brings a visual feast to the rear row with excellent viewing angles at all angles. With the strongest British treasure and excellent sound system in the same class, users in the front and rear rows can enjoy the immersive palace-level music experience.

　　Aouita 12 is not only ingenious in these places that can be seen, touched and heard, but also "haggle over every penny" in places that users can’t see and reach. The golden combination of front double wishbone independent suspension and rear multi-link independent suspension, "one-button unlocking" luxury driving and control experience. High-performance air suspension system+high-performance CDC dynamic suspension damping control can significantly improve driving comfort and handling. With more than 400 adjustment schemes of magic carpet chassis and 29 kinds of road grinding adjustment, it can reduce 75% of body shaking in continuous undulating road scenes, and reduce 58% of bumpy feeling on damaged or unpaved roads, bringing a million-level luxury car-like driving smoothness, ensuring that users can enjoy calmness and elegance in any driving environment.

　　As a smart luxury car in the future, Aouita 12 also creates an extremely elegant look and feel with the future aesthetic design concept. Family-style disc wing front face, unique style, at a glance. All-LED Star-Travel Curvature Light Group, avant-garde modeling shows elegant taste. All quiet and luxurious hatchback without rear porthole, presenting unique recognition with excellent streamline. The wheel height ratio is 0.514, the width height ratio is 1.38, and the axle length ratio is 0.602. With the golden body ratio, it creates an unparalleled pure posture. The high-performance tire with the largest diameter of 265/40/R21 in the same class makes the motion tension of the car body fully displayed.

　　The Aouita 12 Royal Theater Edition, which is listed simultaneously, is extremely exquisite in materials, technology and technology. It also shows the ultimate luxury. The appearance adopts the unique double-color body design, and the joint uses the silver star ring waist line of Rolls-Royce with the same technology, which makes it an unparalleled and elegant artistic masterpiece; The seat leather was upgraded to full grain semi-aniline leather, which matched the traditional hand embroidery process in China. Even the trunk carpet was covered with Merlot red tufted carpet.

　　The listing of Aouita 12 Dual Power will greatly enrich consumers’ expectation and cognition of new luxury cars. With the overall leap in power, intelligent driving, safety and luxury, Aouita 12 will bring more scene choices, higher-end quality enjoyment and more cutting-edge scientific and technological experience to the new energy market. In the future, Aouita Science and Technology will continue to optimize its brand, technology, products, channels and services to meet the growing travel needs of users and create a more unique and futuristic new travel life experience for users.

Lexus RX, as a high-profile luxury SUV, has won the favor of many consumers with its unique design and excellent performance. Starting from 405,000, although the price is expensive, the positioning and exquisite craftsmanship of the large SUV have made it find a foothold in the market.

In terms of appearance, the Lexus RX continues the family’s signature spindle grille, with sharp lines and LED headlight sets showing a luxurious and dynamic temperament. The special design of the C-pillar rear window and the spindle-shaped elements at the rear of the car add a unique visual impact to this model.

The interior shows the usual refinement and luxury of Lexus. Although the steering wheel is designed with mechanical stops, the delicate stitching process and the calm atmosphere give people a sense of luxury. In terms of space, although the rear row only provides sun visors instead of privacy glass, it is equipped with an on-board air purifier and a negative ion generator to ensure the comfort of driving.

In terms of power, the 2.0T engine has a powerful output, with a maximum power of 231 horsepower and a peak torque of 350 N. m. For those who pursue performance and efficiency, this is undoubtedly a highlight. For those who pursue economy, Lexus’ 3.5L V6 engine has excellent performance, but the price threshold is higher.

In terms of the chassis, although the front or four-wheel drive design is adopted, the overall configuration is slightly simpler for medium and large SUVs. For consumers seeking a higher level of driving experience, they may need to consider higher-level models.

Overall, the Lexus RX has found its unique niche in the luxury SUV market with its unique design, luxurious interior and outstanding performance. For cost-effective consumers, this model is indeed worth considering, although its pricing may not be acceptable to everyone.